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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Radiographic follow-up of 84 operatively treated scapula neck and body fractures显示文摘 | Cole P A Gauger E M Herrera D A | | 0，，03： | 1 |
| 3 | Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain显示文摘 | Fitzgerald D P Cole S J Hammond A | 2006 | Neuroscience2006，142，3： | 1 |
| 4 | Non-involuting congenital haemangioma associated with high-output cardiomyopathy 显示文摘 | COLE P KAUFMAN Y METRY D | 2009 | J Plast Reconstr Aesthet Surg2009，62，10： | 1 |
| 5 | Nitropropionic acid of succinate dehydrogenase by 3-nitropropionate 显示文摘 | Coles C J Edmondson D E Singer T P | 1979 | J Biol Chem1979，54，： | 1 |
| 6 | Inactivation of succinate dehydrogenase by 3-nitropropionate显示文摘 | COLES C J EEMONDSON D E SINGER T P | 1979 | J Biol Chem1979，254，： | 1 |
| 7 | Web reinforcement effects on deep beams 显示文摘 | Kong F K Robins P J Cole D F | 1970 | ACI Journal Proceedings1970，67，12： | 1 |
| 8 | High-dose methotrexate in acute lymphoblastic leukemia:Where is the evidence for its continued use 显示文摘 | MANTADAKIS E COLE P D KAMEN B A | 2005 | Pharmocotherapy2005，25，5： | 1 |
| 9 | High-Resolution Mass Spectrometric Characterization of Molecules on Biochar from Pyrolysis and Gasification of Switchgrass 显示文摘 | Cole D P Smith E A Lee Y J | 2012 | Energy ~ Fuels2012，3803，： | 1 |
| 10 | Environmentally-Induced Variation in Starch and Non-starch Polysaccharide Content in Wheat显示文摘 | Coles D Hartunian-Sowa S M Jamieson P D | 1997 | Journal of Cereal Science1997，26，1： | 1 |
| 11 | Effect of inculum rate of biological control agents on preharvest aflatoxin contamina- tion of peanuts显示文摘 | Domer J W Cole R J Blankenship P D | 1998 | Biological Control1998，12，： | 1 |
| 12 | Synthesis and Structures of Mono-and Bis(amidinate)Complexes of Aluminum显示文摘 | Coles M P Swenson D C Jordan R F | 1997 | Organometallics1997，16，： | 1 |
| 13 | Effects of spinal fusion on the proteoglycans of the canine intervertebral disc 显示文摘 | Cole TC Burkhardt D Ghosh P | 1985 | J Orthop Res1985，3，3： | 1 |
| 14 | Zebra mussel invasion in a large, turbid river: Phytoplankton response to increased grazing 显示文摘 | Caraco N F Cole J J Raymond P A Strayer D L Pace M L Findlay Stuart E G Fischer D T | 1997 | Ecology1997，78，2： | 1 |
| 15 | Multiple failure surfaces over dip-slip faults显示文摘 | LADE P V COLE JR D A CUMMINGS D | | 0，，05： | 1 |
| 16 | Biological strategies of nutrient cycling in soil systems显示文摘 | COLEMAN D C RCID C P P COLE C | 1983 | Adrances in Ecological Research1983，13，： | 1 |
| 17 | Dynamic properties of a model polymer/metal nanocomposite:gold particles in poly(tertbutyl acrylate)显示文摘 | Cole D H Shull K R Baldo P | 1999 | Macromolecules1999，32，3： | 1 |
| 18 | Silica aerogel supported catalysts for Fischer-Tropsch synthesis显示文摘 | Dunn B C Cole P Covington D | 2005 | Applied Catalysis A :General2005，278，： | 1 |
| 19 | Effects of spinal fusion on the p roteoglycans of the canine intevertebral disc显示文摘 | 10,Cole T Burkhardt D Ghosh P | 1985 | J Orthop Res,1985，3，9： | 1 |
| 20 | Glutathione transferase activities and herbicide selectivity in maize and associated weed species显示文摘 | Hatton P J Dixon D Cole D J | 1996 | Pesticide Science1996，46，3： | 1 |
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