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| 1 | Generation of anti-idiotypic reagents in the EGFRvⅢ tumor-associated antigen system显示文摘 | Wikstrand CJ Cole VR Crotty LE | 2002 | Cancer Immunol Immunother2002，50，12： | 1 |
| 2 | Bisphosphonate-functionalized goldnanoparticles for contrast-enhanced X-ray detection of breast mi- cro calcifications显示文摘 | Cole LE Vargo-Gogola T Roeder RK | 2014 | Biomaterials2014，35，7： | 1 |
| 3 | Building the Intemet of things using RFID: the RFID ecosystem experience 显示文摘 | WELBOURNE E BATI'LE L COLE G | 2009 | Intemet Computing2009，13，3： | 1 |
| 4 | Bisphosphonate-fimetional- ized goldnanoparticles for contrast-enhanced X-ray detection of breast micro calcifications显示文摘 | Cole LE Vargo-Gogola T Roeder RK | 2014 | Biomaterials2014，35，7： | 1 |
| 5 | Time-dependent effects of safflower oil to improve glycemia,inflammation and blood lipids in obese,post-menopausal women with type 2 diabetes,a randomized,double-masked,crossover study显示文摘 | Asp ML Collene AL Norris LE Cole RM Stout MB Tang SY Hsu JC Belury MA | | 0，，04： | 1 |
| 6 | Separation of hydroxy and polyhydroxy derivatives of 2-carboxy and 2-hydroxymethyl piperidine and pyrrolidine by high-performance liquid chromatography显示文摘 | COLE MD FELLOWS LE | 1988 | J Chromatogr1988，445，： | 1 |
| 7 | GPU-based flow simulation with detailed chemical kinetics显示文摘 | LE H P CAMBIER J L COLE L K | 2012 | Computer Physics Communica- tions2012，184，3： | 1 |
| 8 | Dilution of nebulised aerosolo by air entrainment in children显示文摘 | Collis GC Cole CH Le souef PN | 1990 | Lancet1990，336，： | 1 |
| 9 | Treatment of open femur fractures in children:comparison between external fixator and intramedullary nailing显示文摘 | Ramseier LE Bhaskar AR Cole WG | | 0，，07： | 1 |
| 10 | Reduction and removM of hep- tavalent technetium from solution by Escherichia coli 显示文摘 | Lloyd J R Cole J A Macaskie LE | 1997 | J Bacteriol1997，179，： | 1 |
| 11 | Gold nanoparticles as contrast agents in x-ray imaging and computed tomography显示文摘 | Cole LE Ross RD Tilley JM | 2015 | Nanomedicine(Lond)2015，10，2： | 1 |
| 12 | Nitrogen transformatiom in soil as affected by bacterial-microfaunal interactions显示文摘 | WOODS LE COLE C V ELLIOTT E T | 1982 | Soil Biol Biochem1982，14，： | 1 |
| 13 | Treatment of open femur fractures in children: comparison between ex- ternal fixator and intramedullary nailing 显示文摘 | Ramseier LE Bhaskar AR Cole WG | 2007 | J Pediatr Or- thop2007，27，： | 1 |
| 14 | The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter显示文摘 | Morel F Rauch C Coles B Le Ferrec E Guillouzo A | 2002 | Pharmacogenetics2002，12，4： | 1 |
| 15 | Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival meehanism显示文摘 | Shirey KA Cole LE Keegan AD | 2008 | J Immunol2008，181，6： | 1 |
| 16 | Periopera- tive clinical nurse specialist role delin- eation:a systematic review显示文摘 | Glover DE Newkirk LE Cole LE | 2006 | AORN J2006，84，6： | 1 |
| 17 | 多发性硬化症的治疗时机窗:单克隆抗体治疗的依据显示文摘From 1991- 2002, we treated 58 patients with multiple sclerosis (MS) using the humanised monoclonal antibody, Campath-1H, which causes prolonged T lymphocyte depletion. Clinical and surrogate markers of inflammation were suppressed. In both the relapsing-remitting (RR) and secondary progressive (SP) stages of the illness, Campath-1H reduced the annual relapse rate (from 2.2 to 0.19 and from 0.7 to 0.001 respectively; both p < 0.001). Remarkably, MRI scans of patients with SP disease, treated with Campath-1H 7 years previously, showed no new lesion formation. However, despite these effects on inflammation, disability was differently affected depending on the phase of the disease. Patients with SPMS showed sustained accumulation of disability due to uncontrolled progression marked by unrelenting cerebral atrophy, attributable to ongoing axonal loss. The rate of cerebral atrophy was greatest in patients with established cerebral atrophy and highest inflammatory lesion burden before treatment (2.3 versus 0.7 ml/year; p = 0.04). In contrast, patients with RR disease showed an impressive reduction in disability at 6 months after Campath-1H (by a mean of 1.2 EDSS points) perhaps owing to a suppression of on-going inflammation in these patients with unusually active disease. In addition, there was a further significant, albeit smaller, mean improvement in disability up to 36 months after treatment. We speculate that this represents the beneficial effects of early rescue of neurons and axons from a toxic inflammatory environment, and that prevention of demyelination will prevent long-term axonal degeneration. These concepts are currently being tested in a controlled trial comparing Campath-1H and IFN-beta in the treatment of drug-na ve patients with early, active RR MS. | Coles A.J Cox A Le Page 张慧 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，5： | 0 |
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