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| 1 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | Global epidemiology of hepatitis C virus infection显示文摘 | Colin W Shepard Lyn Finelli Miriam J Alter | 2005 | The Lancet Infectious Diseases2005，，9： | 6 |
| 4 | 荧光光谱法研究蒜头果蛋白与金属离子的相互作用显示文摘蒜头果蛋白(malanin)是从云南、广西特有植物蒜头果中分离纯化出的一种新的、具有抗肿瘤活性的糖蛋白。用荧光光谱法研究了Cu2+,Ag+和Ca2+对malanin和apo-malanin溶液(经EDTA透析脱去金属离子后的脱金属蛋白)荧光强度的影响。结果表明,Cu2+对malanin和apo-malanin荧光均有明显的静态猝灭现象,其离解常数Kd分别为2.37×10-4和2.66×10-4 mol·L-1;Ag+对malanin的荧光强度变化不大,但对apo-malanin荧光强度却有明显的静态猝灭现象,其离解常数Kd为2.37×10-4 mol·L-1;而Ca2+对malanin和apo-malanin荧光强度均无明显变化,说明Ca2+对维持malanin分子天然构象具有重要作用。 | 袁燕 张薇 戴建辉 刘晓芳 王红斌 Colin J Barrow 杨文荣 | 2014 | 光谱学与光谱分析2014，34，12： | 5 |
| 5 | SDS-PAGE电泳法测定蒜头果蛋白的相对分子质量显示文摘蒜头果蛋白(malanin)是从广西、云南特有植物蒜头果中分离、纯化出的一种新的、具有抗肿瘤活性的植物蛋白质.采用变性十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)测定malanin的相对分子质量.结果表明,malanin是一种双链蛋白质,由A、B 2条肽链通过二硫键连接而成,其相对分子质量约为65.94×103.方法具有简单、快速、直观的特点. | 袁燕 王红斌 BARROW Colin J 杨文荣 | 2015 | 云南民族大学学报(自然科学版)2015，24，2： | 4 |
| 6 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 7 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 8 | Buckling and post-buckling of stressed straight-sided wrinkles: experimental AFM observations of bubbles formation and finite element simulations显示文摘 | G Parry C Coupeau J Colin A Cimetière J Grilhé | 2004 | Acta Materialia2004，，13： | 2 |
| 9 | Damage to the corneal endothelium from anterior chamber intraocular lenses in phakic myopic eyes显示文摘 | Mimouni F Colin J Koffi V | 1991 | Refract Corn Surg1991，7，： | 2 |
| 10 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 11 | Oxidation behavior of high strength chain-polyethylene fibers显示文摘 | G Colin | 1988 | Textile Research Journal1988，58，： | 1 |
| 12 | Rh pro teins:key structural and functional components of the red eell membrane显示文摘 | VAN KIM C L COLIN Y CARTRON J P | 2006 | Blood Rev2006，20，： | 1 |
| 13 | Orthodontic tooth movement in the prednisolone-Treated rat显示文摘 | Colin K Laurence J Douglas H | 2000 | Angle Orthod2000，70，： | 1 |
| 14 | A simple, efficient method for the separation of humic substances and DNA from environmental samples显示文摘 | Colin J Jenneifer I--I Dache W | | Appl Environ Microb0，63，12： | 1 |
| 15 | Longitudinal study of children with perinatal braindamage in whom early neurohabilitation was applied: Pre- liminary report显示文摘 | Harmony T Barrera Resendiz J Juarez Colin M E | 2015 | Neurosci Lett2015，611，： | 1 |
| 16 | Functional lymphocyte subset assessment of the Thl/Th2 profile in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocytes显示文摘 | Colin IM Isaac J Dupret P | 2004 | J Biol Regul Homeost Agents2004，1，1： | 1 |
| 17 | Evidence for the adsorption of molecules at special sites located at copper/zinc oxide interfaces (Part 3): Fourier-transform infrared study of methyl formate adsorption on reduced and oxidised Cu/ ZnO/SiO2 catalysts显示文摘 | Graeme J M Colin H R | 1992 | J Chem Soc Faraday Trans1992，88，23： | 1 |
| 18 | Temkin vacuum electronics high power terahertz sources 显示文摘 | John H Booske Richard J Dobbs Colin D Joye Carol L Kory George R Neil Gunn-sik Park Jaehun Park Richard J | 2011 | IEEE transactions on terahertz science and technolo- gy2011，1，1： | 1 |
| 19 | Role of connexin 43in central nervous system injury显示文摘 | Shenton S C Cameron S J Colin R G | 2010 | Exp Neurol2010，225，2： | 1 |
| 20 | Assessment of two objective voice function indices显示文摘 | Piccirillo J Colin P Dennis F | 1998 | Ann Otol Rhinol Laryngol1998，107，： | 1 |
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