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| 1 | 南非国家高中数学课程与评价标准评介显示文摘2012年1月,南非颁布新的高中数学课程标准,较之与以往的南非课程标准相比,新的高中课程标准最为突出的变化体现在对学生评价的重视.在该课程标准中,除对课程颁布的背景、课程目标、课时分配、课程内容有详细介绍之外,还重点强调了对学生学习成就评价的标准.介绍南非高中数学课程标准及其特点,以期为中国高中数学课程改革提供借鉴. | 李娜 曹一鸣 Lyn Webb | 2013 | 数学教育学报2013，22，4： | 25 |
| 2 | Anti-fertility effect of levonorgestrel and quinestrol in Brandt’s voles(Lasiopodomys brandtii)显示文摘The combination of levonorgestrel and quinestrol(EP-1)has been shown to have anti-fertility effects on several wild rodents,but the mechanism underlying these effects is poorly understood.We investigated the effects of EP-1 and each of its components,levonorgestrel(P)and quinestrol(E),on the fertility of Brandt’s voles(Lasiopodomys brandtii)by using a gastric gavage method.The doses for EP-1,E and P were 1,0.34 and 0.66 mg/kg body weight,respectively.Male voles(n=98)were treated daily for 5 or 14 days,then the testes and epididymides were collected,weighed and examined histologically at 30(D30),60(D60)or 90(D90)days after the end of treatment.Four males were allowed to mate with normal females at D90.Female voles(n=75)were treated for 3 days and a further 3 days after a 7-day interval.The uteri and ovaries were weighed and examined histologically at 15(D15),30(D30)or 75(D75)days after the end of treatment.Each of three females were mated with fertile males at D30 and D75,respectively.Our results indicated that quinestrol(E)significantly decreased the sperm numbers in the testes as well as the weight of the testes and epididymides,with both of these tissues showing obvious structural abnormalities,and significantly reduced the litter size and the pup weight for females mated with males of the E treatment group.For female voles,treatment with E,P or EP-1 resulted in no marked influence on the fertility status.These data indicate that quinestrol(E)alone has a significant anti-fertility effect on male Brandt’s voles,but is ineffective in combination with levonorgestrel(P). | Meirong ZHAO Ming LIU Dong LI Xinrong WAN Lyn A.HINDS Yanling WANG Zhibin ZHANG | 2007 | Integrative Zoology2007，2，4： | 6 |
| 3 | Global epidemiology of hepatitis C virus infection显示文摘 | Colin W Shepard Lyn Finelli Miriam J Alter | 2005 | The Lancet Infectious Diseases2005，，9： | 6 |
| 4 | 聚合酶链反应与反向线点杂交检测沙眼衣原体及分型显示文摘目的建立和评价一个新的多重和巢式PCR反向线点杂交试验(RLB)检测泌尿生殖道沙眼衣原体及其分型方法。方法该试验设计了3对引物分别针对CT外膜蛋白(omp1)基因VD2区和质粒进行扩增,用CT15种血清型(A、B/Ba、C、D/Da、E、F、G/Ga、H、I/Ia、J、Ja、K、L1、L2和L3)探针与扩增后的产物杂交。经COBASAmplicor检测的355份标本,其中277份尿液,2份男性直肠拭子和78份女性宫颈试子,进行PCRRLB检测CT并分型。结果192份COBASAmplicor阳性标本中175份PCRRLB阳性,其中93.1%(163/175)的CT感染可被正确分型,其单一型感染分型结果与DNA测序结果一致。163份COBASAmplicor阴性标本中6份巢式PCRRLB阳性。85.3%(139/163)为单一型CT感染,最常见的CT是E(38.6%)F(28.5%)和D(18.2%)。14.7%(24/163)为CT混合感染,混合感染以H和K为主。结论PCRRLB检测CT是一种简便、快速、特异和敏感的方法,并准确的进行CT分型,为CT感染的临床诊断和分子流行病学研究提供了一种可靠的方法。 | 熊礼宽 孔繁荣 周华 程锦泉 Lyn Gilbert | 2006 | 中华检验医学杂志2006，29，3： | 6 |
| 5 | Hepatitis B Virus Infection: Epidemiology and Vaccination显示文摘 | Colin W. Shepard Edgar P. Simard Lyn Finelli Anthony E. Fiore Beth P. Bell | 2006 | Epidemiologic Reviews2006，，： | 6 |
| 6 | The exploitation of epichloae endophytes for agricultural benefit显示文摘Epichloae endophytes of family Clavicipitaceae(comprising genera Epichloëand Neotyphodium)are fungal symbionts of Pooideae grasses.The associations formed,range from mutually beneficial to antagonistic and the nature of this relationship is dependent upon the importance of vertical(via host seeds)versus horizontal(ascospore mediated)transmission of the fungus.These endophytes can enhance their hosts’survival through protection from abiotic and biotic stresses and can thus be utilized in an agricultural context.Animal-safe grass-endophyte associations that confer bio-protective properties for increased pasture persistence and productivity have been developed and commercialized.One of the crucial drivers underpinning the selection of epichloae strains for commercial development is endophyte derived bioactivity.The potential of next generation endophytes is determined by testing a number of attributes such as agronomic fitness,animal and food safety as well as compatibility with host plants of interest.Strategic research supports these activities by focusing on elucidating mechanisms of compatibility between host and fungal symbiont,as well as investigating other molecular drivers of symbiosis such as siderophore mediated iron-uptake,fungal signalling,fungal growth in host plants and fungal secondary metabolism.This review weaves together the different strands of multidisciplinary research aimed at ultimately exploiting epichloae endophytes for increased pasture performance. | Linda J.Johnson Anouck C.M.de Bonth Lyn R.Briggs John R.Caradus Sarah C.Finch Damien J.Fleetwood Lester R.Fletcher David E.Hume Richard D.Johnson Alison J.Popay Brian A.Tapper Wayne R.Simpson Christine R.Voisey Stuart D.Card | 2013 | Fungal Diversity2013，，3： | 5 |
| 7 | “Target” and “Sandwich” Signs in Thigh Muscles have High Diagnostic Values for Collagen VI-related Myopathies显示文摘 | Jun Fu Yi-Ming Zheng Su-Qin Jin Jun-Fei Yi Xiu-Juan Liu He Lyn Zhao-Xia Wang Wei Zhang Jiang-Xi Xiao Yun Yuan | 2016 | Chinese Medical Journal2016，，15： | 5 |
| 8 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 9 | Prevalence and risk factors of methotrexate hepatoxicity in Asian patients with psoriasis显示文摘AIM: To establish the prevalence of liver fibrosis and to evaluate the possible risk factors for fibrosis and progression in Asian with psoriasis treated with methotrexate (MTX) based on liver histology. METHODS: Patients with psoriasis treated with MTX referred to the Department of Gastroenterology, Tan Tock Seng Hospital for liver biopsy were identified and retrospectively studied. Patient case notes and electronic records were retrieved from the hospital database and relevant data collated. Histological changes of liver biopsies were staged according to Roengik score. The factors assessed were age, gender, ethnicity, cumulative dose of MTX, presence of comorbid conditions such as diabetes, hypertension, hyperlipidemia, and ethanol use. We also assessed the histological change in those with multiple liver biopsies. Statistical analysis was performed using Stata V.9.2. RESULTS: There were altogether 59 patients (median age 50 years old, range 22-81 years old, male, 88%) with 98 biopsies liver biopsies; 6 normal [median cumulative dose (MCD), 2285 mg]; 62 gradeⅠ (MCD 2885 mg), 23 grade Ⅱ (MCD 1800 mg) and 7 grade Ⅲ (MCD 1500 mg). There was no grade Ⅳ or cirrhosis. The prevalence of liver fibrosis (grade Ⅲ) was 12%. Of the factors assessed, diabetes (P=0.001) and hypertension (P=0.003) were significant for fibrosis on univariate analysis but not on multivariate analysis. Of the 26 patients who had more than one biopsy (median 2, range 2-6), 57.7% (n=15) were stable, 34.6% (n=9) had progression and 7.7% (n=2) had regression of histological grades. On univariate analysis, nonChinese ethnicity (P=0.031), diabetes (P=0.018), and hyperlipidemia (P=0.011) were predictive of progression of grades, but these were not significant on multivariate analysis. CONCLUSION: Liver fibrosis in Asian psoriatic population on MTX is comparable to the West. Cumulative dose was not associated with liver fibrosis. Metabolic syndrome is important factors. | Chong Meng Yeo Vui Heng Chong Arul Earnest Wei Lyn Yang | 2013 | World Journal of Hepatology2013，5，5： | 3 |
| 10 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 11 | Utility of faecal calprotectin analysis in adult inflammatory bowel disease显示文摘The inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are chronic relapsing, remitting disorders. Diagnosis, along with assessment of disease activity and prognosis present challenges to managing clinicians. Faecal biomarkers, such as faecal calprotectin, are a non-invasive method which can be used to aid these decisions. Calprotectin is a calcium and zinc binding protein found in the cytosol of human neutrophils and macrophages. It is released extracellularly in times of cell stress or damage and can be detected within faeces and thus can be used as a sensitive marker of intestinal inflammation. Faecal calprotectin has been shown to be useful in the diagnosis of IBD, correlates with mucosal disease activity and can help to predict response to treatment or relapse. With growing evidence supporting its use, over the last decade this faecal biomarker has significantly changed the way IBD is managed. | Lyn A Smith Daniel R Gaya | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 12 | Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long‐term iodine prophylaxis and abundant iodine intake显示文摘 | IstvánSzabolcs JanPodoba JoachimFeldkamp OrsolyaDohán IldikóFarkas MihálynéSajgó Krisztina I.Takáts MiklósGóth LászlóKovács KatalinKressinszky PeterHnilica GézaSzilágyi | 2003 | Clinical Endocrinology2003，，1： | 2 |
| 13 | Catastrophic gastrointestinal complication of systemic immunosuppression显示文摘We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone.The patient presented with a diffuse haemorrhagic oesophagitis and a non-specific duodenitis.Biopsies taken from the oesophagus and duodenum demonstrated infection with herpes simplex virus(HSV)and cytomegalovirus(CMV)respectively.Viral infection of the upper gastrointestinal tract is a recognised complication of immunosuppression and HSV is one of the most common pathogens.CMV on the other hand most commonly causes a colitis or less commonly oesophagitis.CMV enteritis is rare as is the synchronous infection with two viral agents in an immunocompromised patient having being described in a few case series only.Viral infection of the gastrointestinal tract in immunocompromised patients should be treated with systemic anti-viral medication and consideration to withdrawal of the immunosuppressive therapy if possible and appropriate.The authors highlight the need for a high suspicion of viral infection in immunosuppressed patients presenting with upper gastrointestinal bleeding. | Lyn Alexandra Smith Mitali Gangopadhyay Daniel R Gaya | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 14 | New ways of looking at old issues: inequality and growth显示文摘 | Klaus Deininger Lyn Squire | 1998 | Journal of Development Economics1998，，2： | 2 |
| 15 | The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis显示文摘Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are multifaceted diseases with genotypic,pathological and clinical overlap.One such overlap is the presence of SQSTM1/p62 mutations.While traditionally mutations manifesting in the ubiquitin-associated domain of p62 were associated with Paget’s disease of bone,mutations affecting all functional domains of p62 have now been identified in amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients.p62 is a multifunctional protein that facilitates protein degradation through autophagy and the ubiquitin-proteasome system,and also regulates cell survival via the Nrf2 antioxidant response pathway,the nuclear factor-kappa B signaling pathway and apoptosis.Dysfunction in these signaling and protein degradation pathways have been observed in amyotrophic lateral sclerosis and frontotemporal lobar degeneration,and mutations that affect the role of p62 in these pathways may contribute to disease pathogenesis.In this review we discuss the role of p62 in these pathways,the effects of p62 mutations and the effect of mutations in the p62 modulator TANK-binding kinase 1,in relation to amyotrophic lateral sclerosis-frontotemporal lobar degeneration pathogenesis. | Adriana Delice Foster Sarah Lyn Rea | 2020 | Neural Regeneration Research2020，15，12： | 2 |
| 16 | 全科医学教育与临床实践相结合显示文摘长久以来,医学教育的重点在于教学内容。然而,最近几十年,教学场所对本科和研究生医学教育也具有越来越重要的意义。医学教育模式的改变与医疗实践的变化密切相关,而后者又受疾病人口学特征改变、技术及医疗投入缩减的影响。 | Lyn Clearihan 邵钧(译) | 2012 | 中国全科医学2012，15，34： | 2 |
| 17 | Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss显示文摘In this article,the mechanism of inheritance behind inherited hearing loss and genetic susceptibilityin noise-induced hearing loss are reviewed.Conventional treatments for sensorineural hearing loss(SNHL),i.e.hearing aid and cochlear implant,are effective for some cases,but not without limitations.For example,they provide little benefit for patients of profound SNHL or neural hearing loss,especially when the hearing loss is in poor dynamic range and with low frequency resolution.We emphasize the most recent evidence-based treatment in this field,which includes gene therapy and allotransplantation of stem cells.Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss.Although some treatments are still at the experimental stage,it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application. | Yong-qiang Yu Huai-an Yang Ming Xiao Jing-wei Wang Dong-yan Huang Yagesh Bhambhani Lyn Sonnenberg Brenda Clark Yuan-zhe Jin Wei-neng Fu Jie Zhang Qian Yu Xue-ting Liang Ming Zhang | 2015 | Chinese Medical Sciences Journal2015，30，3： | 2 |
| 18 | CXC receptor-1 silencing inhibits androgen-independent prostate cancer显示文摘 | Shamaladevi N Lyn DA Escudero DO | 2009 | Cancer Res2009，69，21： | 1 |
| 19 | The Utility of Narrow Band Imaging in Improving the Endoscopic Diagnosis of Gastroesophageal Reflux Disease显示文摘 | Kwong–Ming Fock Eng–Kiong Teo Tiing–Leong Ang Jessica Yi–Lyn Tan Ngai–Moh Law | 2009 | Clinical Gastroenterology and Hepatology2009，，1： | 1 |
| 20 | Removing orbital debris with lasers显示文摘 | Claude R. Phipps Kevin L. Baker Stephen B. Libby Duane A. Liedahl Scot S. Olivier Lyn D. Pleasance Alexander Rubenchik James E. Trebes E. Victor George Bogdan Marcovici James P. Reilly Michael T. Valley | 2012 | Advances in Space Research2012，，9： | 1 |
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