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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | A method for determining optimum sample size in species diversity studies显示文摘 | De Caprariis P Lindemann R H Collins C M | 1976 | Mathematical Geology1976，8，5： | 1 |
| 4 | Simplified modi- fied compression field theory for calculating shear strength of reinforced concrete elements 显示文摘 | Bentz E C Vecehio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 5 | Which Ore field signs/symptoms predict protracted recovery from sport- related concussion among high school football players? 显示文摘 | LAU B C KONTOS A P COLLINS M W | 2011 | Am J Sports Med2011，39，11： | 1 |
| 6 | Effect of Concrete Strength and Minimum Stirrups on Shear Strength Large Members显示文摘 | ANGELAKOS D BENTZ E C COLLINS M P | 2001 | ACI Structural Journal2001，98，3： | 1 |
| 7 | Effects of non-structural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NFkappaB, and proinflammatory eytokines 显示文摘 | Spann K M Tran K C Collins P L | 2005 | J Virol2005，79，9： | 1 |
| 8 | Simplified Modi- fied Compression Field Theory for Calculating Shear Strength of Reinforced Concrete Elements 显示文摘 | Bentz E C Vecehio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 9 | Simplified modified compression field theory for calculating shear strength of reinforced concrete elements显示文摘 | BENTZ E C VECCHIO F J COLLINS M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 10 | Pilomatrixoma or epithelioma of Malherbe invading bone显示文摘 | Wickermaratchi T Collins C M P | 1992 | Histopathology1992，21，1： | 1 |
| 11 | Simplified modifiedcompression field theory for calculating shear strength ofreinforced concrete elements显示文摘 | Bentz E C Vecchio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 12 | Simplified modified compression field theory for calculating shear strength of reinforced concrete elements 显示文摘 | Bentz E C Vecchio F J Collins M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 13 | Molecular cloning and expression analysis of two distinct beta-glucosidase genes, bg and aven,with very different biological roles {rom the ther- mophilic,saprophytic fungus Talaromyces emersoni 显示文摘 | Collins C M Murray P G Denman S | 2007 | Mycol Res2007，111，： | 1 |
| 14 | Osteoblast adherence and resorption activity of isolated osteoclasts on Calcium sulphate hemihydrate显示文摘 | Sidqui M Collin P Vitte C | 1995 | Biomaterials1995，16，17： | 1 |
| 15 | Osteoblast adherence and resorption activity of isolated osteoclasts on calcium sulphate hemihydrate显示文摘 | Sidqui M Collin P Vitte C | 1995 | Biomaterials1995，16，17： | 1 |
| 16 | Cotton rars previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV,a phenomenon not encountered following immunization with vaccinia-RSV recombinants or RSV显示文摘 | Connors M Collins P L Firestone C Y Sotnikov A V Waitze A Davis A R Hung P P Chanock R | | 0，，07： | 1 |
| 17 | Simplified modified compression field theory for ca]culating shear strength of reinforced concrete elements 显示文摘 | BENTZ E C VECCHIO F J COLLINS M P | 2006 | ACI Structural Journal2006，103，4： | 1 |
| 18 | Shear strength of large concrete members with FRP reinforcement 显示文摘 | Bentz E C Massam L Collins M P | 2010 | Journal of Composites for Construction2010，14，6： | 1 |
| 19 | Osteoblast adherence and re- sorption activity of isolated osteoblasts on calcium sulfate hemihy- drate显示文摘 | Sidqui M Collin P Vitte C | 1995 | Siomaterials1995，16，17： | 1 |
| 20 | Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control显示文摘 | Rodriguez V P Collins C Fried M | 2006 | Proc Nail Acad Sci USA2006，103，19： | 1 |
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