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| 1 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Trust Relations in High-Reliability Organizations显示文摘 | Cox S Jones B Collinson D | 2006 | (5):1123-11382006，，5： | 1 |
| 3 | Biomarkers of cardiovasculardamage显示文摘 | COLLINSON P 0 GAZE D C | 2007 | Med Princ Pract2007，16，4： | 1 |
| 4 | Magnetism of the Moon-a lunar core dynamo or impact magnetization显示文摘 | Collinson D W | 1993 | Surveys in Geophysics1993，14，1： | 1 |
| 5 | Comparison of contemporarytroponin assays with the novel biomarkers,heart fatty acid bindingprotein and copeptin, for the early confirmation or exclusion of my-ocardial infarction in patients presenting to the emergency depart-ment with chest pain显示文摘 | Collinson P Gaze D Goodacre S | 2014 | Heart2014，100，2： | 1 |
| 6 | Assay imprecision and 99th-percentile reference value of a high- sensitivity cardiac troponin I assay显示文摘 | Collinson PO Clifford-Mobley O Gaze D | 2009 | Clin Chem2009，55，： | 1 |
| 7 | Episodic fire, runoff and deposition at the Palaeocene-Eocene boundary 显示文摘 | Collinson M E Steart D C Scott A C | 2007 | Journal of the Geological Society2007，164，： | 1 |
| 8 | Influence of populationselection on the 99th percentile reference value for cardiac troponin assays 显示文摘 | Collinson PO Heung YM Gaze D | 2012 | Clin Chem2012，58，11： | 1 |
| 9 | Prognostic significance of admission troponin T concentration in patients with myocardial infarction显示文摘 | Stubbs P Collinson P Moseley D | 1994 | Circulation1994，94，： | 1 |
| 10 | Extrapolative Prediction of the Hot Strength of Austenitic Steels with a Combined Constitutive and ANN Model显示文摘 | KONG L X HODGSON P D COLLINSON D C | 2000 | Journal of Materials Precesssing Technology2000，102，： | 1 |
| 11 | Frontal executive impairment associated with paraneoplastic cerebellar degeneration:a case study显示文摘 | Collinson SL Anthonisz B Courtenay D | 2006 | Neurocase2006，12，6： | 1 |
| 12 | Prognostic significance of admission troponin T concentrations in patients with myocardial infarction显示文摘 | Collinson P Moseley D | 1996 | Circulation1996，94，6： | 1 |
| 13 | 'Engineering humor': Masculinity, joking and conflict in ship-floor relations显示文摘 | Collinson D | 1988 | Organ isation Studies1988，，9： | 1 |
| 14 | Prognostic signif icance of admission troponin T concentrations in patients with myocardial infarction显示文摘 | Collinson P Moseley D | 1996 | Circulation1996，94，6： | 1 |
| 15 | Biomarkers of cardiovascular damage and dys- function- an overview 显示文摘 | Collinson PO Gaze D | 2007 | Heart Lung and Circulation2007，16，3： | 1 |
| 16 | Measurement of Cardiac troponins显示文摘 | COLLINSON P O BOA F G GAZE D C | 2001 | Am Clin Bioehem2001，38，5： | 1 |
| 17 | Influence of pop- ulation selection on the 99th percentile reference value for cardiac troponin assays显示文摘 | Collinson PO Heung YM Gaze D | 2012 | Clin Chem2012，58，1： | 1 |
| 18 | Geology and mineralization of the Grasberg porphyry copper-gold deposit, Irian Jaya, Indonesia 显示文摘 | Van Nort S D Atwood G W Collinson T B | 1991 | Mining Engineering1991，43，3： | 1 |
| 19 | Rethinking followership:A post-structuralist analysis of follower Identities显示文摘 | Collinson D | 2006 | The Leadership Quarterly2006，17，2： | 1 |
| 20 | Changes in blood gas samples produced by a pneumatic tube system显示文摘 | COLLINSON P O JOHN C M GAZE D C | 2002 | J Clin Pathol2002，55，2： | 1 |
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