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| 1 | Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion显示文摘 | Sheng-Long Ye Xun-Ke Gu Li-Yuan Tao Ji-Mei Cong Yong-Qing Wang | 2017 | Chinese Medical Journal2017，，12： | 30 |
| 2 | Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells显示文摘体的房间能由定义因素是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed。reprogramming 的低效率和 oncogenes 和病毒的向量的 genomic 集成限制了 iPSCs 的潜在的申请。这里,我们报导那锂(李) ,药过去常对待心情混乱,极大地从老鼠提高 iPSC 产生胚胎的成纤维细胞和人的脐的静脉 endothelial 房间。李与(Oct4 ) 或二个因素(OS 或好) 便于 iPSC 产生。支持 reprogramming 上的李的效果仅仅部分取决于它的主要目标 GSK3β。不同于另外的 GSK3β禁止者,李不仅增加 Nanog 的表示,而且提高 Nanog 的 transcriptional 活动。我们也发现李由经由 LSD1 的 downregulation 支持 epigenetic 修正施加它的效果, H3K4 特定的 histone demethylase。将 LSD1 击倒部分在提高 reprogramming 模仿李的效果。我们的结果不仅提供一个直接方法改进 iPSC 产生效率,而且为体的房间 reprogramming 作为一个批评调节的人识别了 histone demethylase。 | Quan Wang Xinxiu Xu Jun Li Jing Liu Haifeng Gu Ru Zhang Jiekai Chen Yin Kuang Jian Fei Cong Jiang Ping Wang Duanqing Pei Sheng Ding Xin Xie | 2011 | Cell Research2011，21，10： | 23 |
| 3 | The estimate of sea ice resources quantity in the Bohai Sea based on NOAA/AVHRR data显示文摘The research on sea ice resources is the academic base of sea ice exploitation in the Bohai Sea. According to the ice-water spectrum differences and the correlation between ice thickness and albedo, this paper comes up with a sea ice thickness inversion model based on the NOAA/AVHRR data. And then a sea ice resources quantity (SIQ) time series of Bohai Sea is established from 1987 to 2009. The results indicate that the average error of inversion sea ice thickness is below 30%. The maximum sea ice resources quantity is about 6 × 10 9 m 3 and the minimum is 1.3 × 10 9 m 3 . And a preliminary analysis has been made on the errors of the estimate of sea ice resources quantity (SIQ). | YUAN Shuai GU Wei XU Yingjun WANG Ping HUANG Shuqing LE Zhangyan CONG Jianou | 2012 | Acta Oceanologica Sinica2012，31，1： | 15 |
| 4 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 5 | Screening beneficial bacteriostatic lactic acid bacteria in the intestine and studies of bacteriostatic substances显示文摘Lactic acid bacteria(LAB)are a representative probiotic.As the dominant flora in the human intestinal tract,LAB can regulate the balance of human intestinal flora and improve host health.The purpose of this study was to isolate and screen LAB that are well suited to the intestinal characteristics of the Chinese population,with excellent probiotics and high antibacterial activity.After 16S ribosomal RNA(rRNA)homology and phylogenetic tree analysis,potential probiotics were tested for their antibacterial activity,resistance to artificial gastrointestinal fluid and drugs,surface hydrophobicity,and safety.Three strains of LAB with acid resistance,bile salt resistance,epithelial cell adhesion,and no multidrug resistance were selected:Lactobacillus salivarius,Leuconostoc lactis,and Lactobacillus paracasei.Analysis of the antibacterial active substances in the three strains and their fermentation broths revealed that the main antibacterial substances of L.lactis were organic acids,whereas those of L.salivarius and L.paracasei were organic acids and bacteriocins with broad-spectrum antibacterial activity.These three strains of probiotic LAB with high antibacterial activity were identified as bacterial resources that could potentially be used to develop probiotic preparations for the prevention and treatment of intestinal diseases caused by intestinal pathogens. | Zhijing LIU Cong XU Ran TIAN Wan WANG Jiage MA Liya GU Fei LIU Zhanmei JIANG Juncai HOU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，7： | 10 |
| 6 | Combined hepatocellular and cholangiocarcinoma originating from the same clone:a pathomolecular evidence-based study显示文摘Background:Combined hepatocellular and cholangiocarcinoma(CHC) is a unique subtype of liver cancer comprising both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC);however,its cellular origin remains unclear.The purpose of this study was to investigate the clinicopathologic features and the clonal relationship between HCC and ICC in 34 patients with CHC.Methods:The clinicopathologic features and prognosis of the 34 CHC patients were compared with those of 29 patients with separated HCC and ICC(5HC).Loss of heterozygosity(LOH) at 10 highly polymorphic microsatellite markers was detected in 16 CHC and 10 SHC tissues for determination of the clonal origin of CHC.Expression of hepatocyte markers[hepatocyte paraffin 1(Hep Par 1) and glypican 3(GPC3)]and cholangiocyte markers[cytokeratin(CK)7 and 19]in tumor tissues was examined by immuno histochemical analysis.Results:In the 16 CHC specimens,the difference in LOH patterns between HCC and ICC was less than 30%,suggesting the same clonal origin of HCC and ICC.Consistent with this finding,immunohistochemical analysis revealed that hepatocyte markers(Hep Par 1 and GPC3) and cholangiocyte markers(CK7 and CK19) were simultaneously expressed in both the HCC and ICC components in 52.9%of CHC specimens,suggesting that the two components shared a similar phenotype with hepatic progenitor cells(HPCs).On the contrary,in all 10 SHC cases,the difference in LOH patterns between the HCC and ICC components was greater than 30%,suggesting different clonal origins of HCC and ICC.Overall survival and disease-free survival were shorter for patients with CHC than for patients with SHC(P < 0.05).Conclusions:Our results suggest that the HCC and ICC components of CHC may originate from the same clone,having the potential for dual-directional differentiation similar to HPCs.CHC tended to exhibit the biological behaviors of both HCC and ICC,which may enhance the infiltrative capacity of tumor cells,leading to poor clinical outcomes for patients with CHC. | Qian Zhao Wen-Long Yu Xin-Yuan Lu Hui Dong Yi-Jin Gu Xia Sheng Wen-Ming Cong Meng-Chao Wu | 2016 | Chinese Journal of Cancer2016，35，11： | 9 |
| 7 | Gly(82)Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population显示文摘 | Gu, H.J. Yang, L. Sun, Q. M. Zhou, B. Tang, N. P. Cong, R. H. Zeng, Y. Wang, B. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 9 |
| 8 | Carbendazim sensitivity in populations of Colletotrichum gloeosporioides complex infecting strawberry and yams in Hubei Province of China显示文摘The ascomycete fungus Colletotrichum gloeosporioides is a devastating plant pathogen with a wide host range and worldwide distribution. Carbendazim has been widely used to control anthracnose caused by the C. gloeosporioides complex in China for more than 30 years and resistance to carbendazim has been reported in China. A total of 125 Colletotrichum isolates of strawberry and yam were collected from different geographical regions in Hubei Province, China. Approximately 52.8% of Colletotrichum spp. isolates showed resistance to carbendazim. The isolates tested in this study belong to four species, and the frequencies of resistant isolates differed across Colletotrichum species. Resistant isolates were found in C. siamense and C. fructicola. In contrast, all isolates of C. gloeosporioides and C. aenigma were sensitive to carbendazim. Highly carbendazim-resistant isolates harbored the E198 A mutation in the β-tubulin 2(TUB2) gene, whereas moderately carbendazim-resistant isolates harbored the F200 Y mutation in the TUB2 gene. Carbendazim-sensitive Colletotrichum isolates in this study were not genetically similar enough to form a separate cluster from resistant isolates. The result of this study emphasizes the importance of knowing which Colletotrichum sp. is present, when strategies for disease control are made. | HAN Yong-chao ZENG Xiang-guo XlANG Fa-yun ZHANG Qing-hua GUO Cong CHEN Feng-ying GU Yu-chen | 2018 | Journal of Integrative Agriculture2018，17，6： | 9 |
| 9 | Effect of cholecystokinin octapeptide on diacylglyceroI-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide显示文摘Aim:To investigate the effect of cholecystokinin octapeptide(CCK-8)on thediacylglycerol-protein kinase C(DAG-PKC)signaling pathway in rat pulmonaryinterstitial macrophages(PIM)stimulated by lipopolysaccaride(LPS).Methods:The PIM from rat lung tissues were isolated using the collagenase digestionmethod combined with alveolar lavage and pulmonary vessel perfusion.DAGcontent and PKC activity were measured by radioenzymatic assay.The transloca-tion of PKCζ was determined by semi-quantitative immunoblot analysis.Results:CCK-8,at high concentrations(1×10^(-6)-1×10^(-5)mol/L),decreased DAG content andinhibited PKC activity and PKCζ translocation compared with that in rat restingPIM of a control group(P<0.01).LPS increased DAG content,and promoted PKCactivity and PKC~ translocation(P<0.01).CCK-8 decreased LPS-induced DAGcontent and inhibited LPS-induced PKC activity and PKCζ translocation signifi-cantly at 1×10^(-8)-1×10^(-5)mol/L(P<0.01).This inhibitory effect of CCK-8 could beabrogated partly by proglumide(non-selective CCK receptor antagonist),CR-1409(selective CCK-A receptor antagonist),and CR-2945(selective CCK-Breceptor antagonist)in a concentration-dependent manner(P<0.01).Conclusion:CCK-8 was a negative modulator of the DAG-PKC signaling pathway in rat restingPIM,which is very important for maintaining body homeostasis.It significantlyinhibited LPS-induced DAG content,PKC activity and PKCζ translocation in aconcentration-dependent manner.The CCK receptor,especially the CCK-Areceptor,might play a major role in this process. | Shun-jiang XU Wei-juan GAO Bin CONG Chun-ling MA Shu-jin LI Yi-ling LING Zhen-yong GU Yu-xia YAO | 2005 | Acta Pharmacologica Sinica2005，26，12： | 6 |
| 10 | Combining Ability and Genetic Effects of Germination Traits of Brassica napus L.Under Waterlogging Stress Condition显示文摘Cross combinations from six rapeseed cultivars and lines were evaluated under waterlogging stress condition in order to understand the genetic mechanism of waterlogging tolerance of Brassica napus L.and provide reasonable improvement programs.There were six germination traits investigated on combining ability and heritability using complete diallel crossing method designed for 30 combinations from those six cultivars and lines.The traits included relative root length,stem length,fresh weight per plant,survival rate,electrical conductivity,and vigor index.After flooding treatment,the six traits of parents and F1 were analyzed.The general combining ability(GCA) and special combining ability(SCA) of germination traits were analyzed using Griffing I method.Among 30 cross combinations,the GCA was significantly different among six waterlogging resistance traits.The SCA of these traits was significantly different except the SCA of electrical conductivity.As a representative trait of waterlogging tolerance in rapeseed,relative vigor index had the highest narrow heritability and relatively low broad heritability.The cultivars Zhongshuang 9 and P79 had higher tolerance potential to waterlogging stress.It can be concluded that combining ability and genetic effects of relative vigor index during germination stage could be used to identify the waterlogging tolerance of rapeseed in breeding program. | CHENG Yong GU Min CONG Ye ZOU Chong-shun ZHANG Xue-kun WANG Han-zhong | 2010 | Agricultural Sciences in China2010，9，7： | 5 |
| 11 | Thermophysical properties of a novel high entropy hafnate ceramic显示文摘High-entropy oxides(HEOs)are considered promising thermal barrier coating(TBC)materials due to their unique thermophysical performances induced by the entropy effects.In this work,(La_(0.2)Ce_(0.2)Pr_(0.2)Sm_(0.2)Eu_(0.2))_(2)Hf_(2)O_(7)high entropy hafnate,as a thermal barrier coating(TBC)material,was successfully synthesized by solution combustion method for the first time.From the X-ray diffraction,scanning electron microscopy,and transmission electron microscopy results,it is confirmed that(La_(0.2)Ce_(0.2)Pr_(0.2)Sm_(0.2)Eu_(0.2))_(2)Hf_(2)O_(7)has pure single-phase ordered pyrochlore structure with highly homogeneous composition at both micrometer and nanometer scales.The synthesized(La_(0.2)Ce_(0.2)Pr_(0.2)Sm_(0.2)Eu_(0.2))2 Hf2O7 possesses excellent phase stability at 1600℃and demonstrates a low thermal conductivity(1.0-1.24 W·m^(-1)·K^(-1))which is lower than those of rare earth hafnates(RE2Hf2O7,RE=La,Ce,Pr,Sm,Eu).Therefore,it provides a new perspective and potential to prompt the next generation TBC materials with better performance. | Longkang Cong Shouyang zhang Shengyue Gu Wei Li | 2021 | Journal of Materials Science & Technology2021，，26： | 4 |
| 12 | High-entropy(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))2Hf_(2)O_(7) ceramic: A promising thermal barrier coating material显示文摘Thermal barrier coating(TBC)materials perform an increasingly important role in the thermal or chemical protection of hot components in a gas turbine.In this study,a novel high entropy hafnate(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))_(2)Hf_(2)O_(7) was synthesized by solution combustion method and investigated as a potential TBC layer.The as-synthesized(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))_(2)Hf_(2)O_(7) possesses a pure single disordered fluorite phase with a highly homogeneous distribution of rare earth(RE)cations,exhibiting prominent phase stability and excellent chemical compatibility with Al_(2)O_(3) even at 1300°C.Moreover,(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))_(2)Hf_(2)O_(7) demonstrates a more sluggish grain growth rate than Y_(2)Hf_(2)O_(7).The thermal conductivity of(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))_(2)Hf_(2)O_(7)(0.73-0.93 W m^(-1)K^(-1))is smaller than those of components RE_(2)Hf_(2)O_(7) and many high entropy TBC materials.Beside,the calculated thermal expansion coefficient(TEC)of(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))_(2)Hf_(2)O_(7)(10.68×10^(-6)/K,1100°C)is smaller than that of yttriastabilized zirconia(YSZ).Based on the results of this work,(Y_(0.2)Gd_(0.2)Dy_(0.2)Er_(0.2)Yb_(0.2))_(2)Hf_(2)O_(7) is suitable for the next generation TBC materials with outstanding properties. | Longkang Cong Wei Li Jiancheng Wang Shengyue Gu Shouyang Zhang | 2022 | Journal of Materials Science & Technology2022，，6： | 4 |
| 13 | Predictors of super-response to cardiac resynchronization therapy: the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing显示文摘BackgroundSuper 应答者(SR ) 被定义为在心脏的再同步治疗(CRT ) 以后显示出关键心脏的功能改进的病人。这研究的目的是在 CRT.MethodsThis 学习注册了从 2010 ~ 2014 在时期期间经历了 CRT 的 201 个病人以后,识别并且验证 SR 的预言者。临床并且 echocardiographic 评估在 CRT 和 6 个月前被进行在以后。有在纽约心协会(NYHA ) 的减少的病人功能的班 1,在左室的结束收缩的体积(LVESV ) 的减少 15% ,并且最后的左室的喷射部分(LVEF ) 当经历了 CRT 的 201 个病人的 SRs.Results29% 作为 SR 被识别, 45% 被分类。在基线, SR 有显著地更小的左 atrial 直径(男孩) , LVESV,左室的结束心脏舒张的体积(LVEDV ) 和比 non-super-responders (non-SRs ) 的更高的 LVEF。用变换血管收缩素的酶禁止者或血管收缩素受体 blockers (ACEI/ARB ) 的病人的百分比比 non-SRs 在 SR 是更高的。大多数 SR 有 Biventricular (BiV ) 在 CRT 以后在比 98% 六个月大的百分比上踱步。在 multivariate 逻辑回归分析, SR 的独立预言者是更低的 LVEDV [奇怪的比率(或) :0.93;信心间隔(CI ) :0.90-0.97 ] , ACEI/ARB 的使用(或:0.33;CI:0.13-0.82 ) 并且比 98% 大的 BiV 踱步百分比(或:0.29;CI:0.16-0.87 ) 有 ACEI/ARB 和更少 ectatic 的更好的依从的 .ConclusionPatients 在 CRT 前的室的几何学趋于有成为 SR 的更大的可能性。BiV 踱步的更高的百分比为成为 SR 是必要的。 | Han JIN Min GU Wei HUA Xiao-Han FAN Hong-Xia NIU Li-Gang DING Jing WANG Cong XUE Shu ZHANG | 2017 | Journal of Geriatric Cardiology2017，14，12： | 4 |
| 14 | Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population显示文摘TP53,一个 transcriptional 管理者和肿瘤 suppressor,在精子发生是机能上地重要的。MDM2 是 p53 小径的一个关键管理者并且调制 p53 活动。两蛋白质机能上地被连接了到细菌房间 apoptosis,它可以影响人的不孕,但是几乎不在在这些基因的普通多型性怎么可以影响细菌房间 apoptosis 和男不孕的风险上被知道。因此,这研究被设计测试三是否以前描述了多型性 72Arg >专业版(rs1042522 ) 和 Ex2+ 19C >在 TP53 的 T (rs2287498 ) ,和 5 ′untranslated 区域(5 ′UTR ) 309T >在 MDM2 的 G (rs937283 ) ,在一张中国人口与自发的男不孕被联系。三多型性是用在基于医院的盒子控制研究的 OpenArray 试金的 genotyped,包括 580 个不肥沃的病人和 580 肥沃的控制。我们的分析揭示了那 TP53 Ex2+ 19C > T 和 MDM2 309T > G 多型性与男不孕被联系。而且,我们为男不孕的发展检测了在 TP53 rs2287498 和 MDM2 rs937283 之间的一个将近统计上重要的添加剂相互作用(P 相互作用 =0.055) 。在摘要,这研究发现了初步的证据,证明在 TP53 小径的基因的基因变体是为男不孕的风险因素。 | Cong Huang Wei Liu Gui-Xiang Ji Ai-Hua Gu Jian-Hua Qu Ling Song Xin-Ru Wang | 2012 | Asian Journal of Andrology2012，14，5： | 4 |
| 15 | Polarization-independent all-silicon dielectric metasurfaces in the terahertz regime显示文摘Dielectric metasurfaces have achieved great success in realizing high-efficiency wavefront control in the optical and infrared ranges. Here, we experimentally demonstrate several efficient, polarization-independent, all-silicon dielectric metasurfaces in the terahertz regime. The metasurfaces are composed of cylindrical silicon pillars on a silicon substrate, which can be easily fabricated using etching technology for semiconductors. By locally tailoring the diameter of the pillars, full control over abrupt phase changes can be achieved. To show the controlling ability of the metasurfaces, an anomalous deflector, three Bessel beam generators, and three vortex beam generators are fabricated and characterized. We also show that the proposed metasurfaces can be easily combined to form composite devices with extended functionalities. The proposed controlling method has promising applications in developing low-loss, ultra-compact spatial terahertz modulation devices. | HUIFANG ZHANG XUEQIAN ZHANG QUAN XU QIU WANG YUEHONG XU MINGGUI WEI YANFENG LI JIANQIANG GU ZHEN TIAN CHUNMEI OUYANG XIXIANG ZHANG CONG HU JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 4 |
| 16 | Epidemiological trends of urinary tract infections,urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019显示文摘Background:Urinary tract infections(UTI),urolithiasis,and benign prostatic hyperplasia(BPH)are three of the most common nonmalignant conditions in urology.However,there is still a lack of comprehensive and updated epidemiological data.This study aimed to investigate the disease burden of UTI,urolithiasis,and BPH in 203 countries and territories from 1990 to 2019.Methods:Data were extracted from the Global Burden of Disease 2019,including incident cases,deaths,disabilityadjusted life-years(DALYs)and corresponding age-standardized rate(ASR)from 1990 to 2019.Estimated annual percentage changes(EAPC)were calculated to evaluate the trends of ASR.The associations between disease burden and social development degrees were analyzed using a sociodemographic index(SDI).Results:Compared with 1990,the incident cases of UTI,urolithiasis,and BPH increased by 60.40%,48.57%,and 105.70%in 2019,respectively.The age-standardized incidence rate(ASIR)of UTI increased(EAPC=0.08),while urolithiasis(EAPC=–0.83)and BPH(EAPC=–0.03)decreased from 1990 to 2019.In 2019,the age-standardized mortality rate(ASMR)of UTI and urolithiasis were 3.13/100,000 and 0.17/100,000,respectively.BPH had the largest increase(110.56%)in DALYs in the past three decades,followed by UTI(68.89%)and urolithiasis(16.95%).The burden of UTI was mainly concentrated in South Asia and Tropical Latin America,while the burden of urolithiasis and BPH was recorded in Asia and Eastern Europe.Moreover,the ASIR and SDI of urolithiasis in high-SDI regions from 1990to 2019 were negatively correlated,while the opposite trend was seen in low-SDI regions.In 2019,the ASIR of UTI in females was 3.59 times that of males,while the ASIR of urolithiasis in males was 1.96 times higher than that in females.The incidence was highest in the 30–34,55–59,and 65–69 age groups among the UTI,urolithiasis,and BPH groups,respectively.Conclusions:Over the past three decades,the disease burden has increased for UTI but decreased for urolithiasis and BPH.The allocation of medical resources should be based more on the epidemiological characteristics and geographical distribution of diseases. | Cong Zhu Dan-Qi Wang Hao Zi Qiao Huang Jia-Min Gu Lu-Yao Li Xing-Pei Guo Fei Li Cheng Fang Xiao-Dong Li Xian-Tao Zeng | 2022 | Military Medical Research2022，9，4： | 4 |
| 17 | α1-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation显示文摘Acute sympathetic stress causes excessive secretion of catecholamines and induces cardiac injuries,which are mainly mediated byβ-adrenergic receptors(β-ARs).However,α1-adrenergic receptors(α1-ARs)are also expressed in the heart and are activated upon acute sympathetic stress.In the present study,we investigated whetherα1-AR activation induced cardiac inflammation and the underlying mechanisms.Male C57BL/6 mice were injected with a single dose ofα1-AR agonist phenylephrine(PE,5 or 10 mg/kg,s.c.)with or without pretreatment withα-AR antagonist prazosin(5 mg/kg,s.c.).PE injection caused cardiac dysfunction and cardiac inflammation,evidenced by the increased expression of inflammatory cytokine IL-6 and chemokines MCP-1 and MCP-5,as well as macrophage infiltration in myocardium.These effects were blocked by prazosin pretreatment.Furthermore,PE injection significantly increased the expression of NOD-like receptor protein 3(NLRP3)and the cleavage of caspase-1(p20)and interleukin-18 in the heart;similar results were observed in both Langendorff-perfused hearts and cultured cardiomyocytes following the treatment with PE(10μM).Moreover,PE-induced NLRP3 inflammasome activation and cardiac inflammation was blocked in Nlrp3-/-mice compared with wild-type mice.In conclusion,α1-AR overactivation induces cardiac inflammation by activating NLRP3 inflammasomes. | Jun-zhou Xin Ji-min Wu Guo-min Hu Hui-jun Gu Ye-nan Feng Shuai-xing Wang Wen-wen Cong Ming-zhe Li Wen-li Xu Yao Song Han Xiao You-yi Zhang Li Wang | 2020 | Acta Pharmacologica Sinica2020，41，3： | 4 |
| 18 | Operando HERFD-XANES and surface sensitive Δμ analyses identify the structural evolution of copper(Ⅱ) phthalocyanine for electroreduction of CO_(2)显示文摘The quantitative understanding of how atomic-level catalyst structural changes affect the reactivity of the electrochemical CO_(2)reduction reaction is challenging.Due to the complexity of catalytic systems,conventional in situ X-ray spectroscopy plays a limited role in tracing the underlying dynamic structural changes in catalysts active sites.Herein,operando high-energy resolution fluorescence-detected X-ray absorption spectroscopy was used to precisely identify the dynamic structural transformation of well-defined active sites of a representative model copper(Ⅱ)phthalocyanine catalyst which is of guiding significance in studying single-atom catalysis system.Comprehensive X-ray spectroscopy analyses,including surface sensitive△μspectra which isolates the surface changes by subtracting the disturb of bulk base and X-ray absorption near-edge structure spectroscopy simulation,were used to discover that Cu species aggregated with increasing applied potential,which is responsible for the observed evolution of C_(2)H_(4).The approach developed in this work,characterizing the active-site geometry and dynamic structural change,is a novel and powerful technique to elucidate complex catalytic mechanisms and is expected to con tribute to the rational design of highly effective catalysts. | Bingbao Mei Cong Liu Ji Li Songqi Gu Xianlong Du Siyu Lu Fei Song Weilin Xu Zheng Jiang | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 19 | Two closely neighboring hepatocellular carcinomas mimicking intrahepatic metastasis are confirmed as double primary tumors by the loss of heterozygosity analysis of microsatellites显示文摘Hepatocellular carcinoma (HCC) is a common malignancy around the world.Among all HCCs,multifocal HCC accounts for 12%-19%.1 The origin of multifocal HCC can either be the intrahepatic metastasis of a single tumor clone,or independent primaries.2 It is crucial to distinguish intrahepatic metastatic tumor from multicentric HCC because this distinction has significant impact on tumor staging,treatment plan,and clinical outcome.Routine histological examination alone cannot determine the clonal origin of multifocal HCC and usually results in their arbitrary classification as satellite nodules.The only way to reliably determine clonality among multiple lesions is by molecular genetic analysis.We report a patient who underwent surgical resection for two neighboring hepatocellular carcinomas that were from independent primaries.These separate nodules mimicked a solitary primary with intrahepatic metastasis.Confirmation of separate clones was established by the loss of heterozygosity (LOH) of microsatellites. | ZHU Zhen ZHU Hong-fa GU Yi-jin CONG Wen-ming | 2013 | Chinese Medical Journal2013，，16： | 3 |
| 20 | Dynamic activity of NF-κB in multiple trauma patients and protective effects of ulinastain显示文摘 | LI Jun LI Neng-ping GU Yong-feng YANG Xin LU Xiao-bing CONG Jian-nong LING Yun TANG Jiang-an YUAN Xiao-yan WANG Hu | 2011 | Chinese Journal of Traumatology2011，14，6： | 3 |
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