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| 1 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 2 | Rigid elliptical cross-section ogive-nose projectiles penetration into concrete targets显示文摘The elliptical cross-section ogive-nose projectile(ECOP) has recently attracted attention because it is well suited to the flattened shape of earth-penetrating weapons. However, the penetration performance of ECOPs has not been completely understood. The objective of this study was to investigate the penetration performance of ECOPs into concrete targets using a theoretical method. A general geometric model of ECOPs was introduced, and closed-form penetration equations were derived according to the dynamic cavity-expansion theory. The model was validated by comparing the predicted penetration depths with test data, and the maximum deviation was 15.8%. The increment in the penetration depth of the ECOP was evaluated using the proposed model, and the effect of the majoreminor axis ratio on the increment was examined. Additionally, the mechanism of the penetration-depth increment was investigated with respect to the caliber radius head, axial stress, and resistance. | Xiang-hui Dai Ke-hui Wang Ming-rui Li Jian Duan Bing-wen Qian Gang Zhou | 2021 | Defence Technology(防务技术)2021，17，3： | 9 |
| 3 | Field Capacity in Black Soil Region, Northeast China显示文摘In this work, 23 black soil profiles were surveyed and 113 soil samples were collected to determine the field capacity (FC) of the black soil in Northeast China. The effectiveness of three methods measuring FC, the Wilcox method (WM), the undisturbed soil pressure plate method (PUM) and the air-dried sieved soil pressure plate method (PDM) were compared to select a suitable laboratory measurement method. Results show that the FC values measured by PDM are greater than those measured by PUM, and the values measured by PUM are greater than those measured by WM. PUM is more suitable for the determination of FC in the study area. One regression equation between PUM and PDM has been established through which undisturbed soil can be replaced by air-dried sieved soil, which is easier to get, to measure FC. FCs vary from 23.50% to 37.00%, with an average of 31.65%, which differ greatly among the 23 black soil profiles. FC is found to be significantly positively correlated with the silt content, clay content and bulk density of the soil, but significantly negatively correlated with the sand content. An empirical pedotransfer function is established to estimate the FC using available soil physical and chemical properties. | DUAN Xingwu XIE Yun LIU Gang GAO Xiaofei LU Hongmei | 2010 | Chinese Geographical Science2010，20，5： | 9 |
| 4 | Mathematical and computational approaches to epidemic modeling: a comprehensive review显示文摘 | Wei DUAN Zongchen FAN Peng ZHANG Gang GUO Xiaogang QIU | 2015 | Frontiers of Computer Science2015，9，5： | 7 |
| 5 | Isolation and identification of symbiotic bacteria from the skin, mouth, and rectum of wild and captive tree shrews显示文摘Endosymbionts influence many aspects of their hosts’ health conditions, including physiology, development, immunity, metabolism, etc. Tree shrews(Tupaia belangeri chinensis) have attracted increasing attention in modeling human diseases and therapeutic responses due to their close relationship with primates. To clarify the situation of symbiotic bacteria from their body surface, oral cavity, and anus, 12 wild and 12 the third generation of captive tree shrews were examined. Based on morphological and cultural characteristics, physiological and biochemical tests, as well as the 16 S rDNA full sequence analysis, 12 bacteria strains were isolated and identified from the wild tree shrews: body surface: Bacillus subtilis(detection rate 42%), Pseudomonas aeruginosa(25%), Staphlococcus aureus(33%), S. Epidermidis(75%), Micrococcus luteus(25%), Kurthia gibsonii(17%); oral cavity: Neisseria mucosa(58%), Streptococcus pneumonia(17%); anus: Enterococcus faecalis(17%), Lactococus lactis(33%), Escherichia coli(92%), Salmonella typhosa(17%); whereas, four were indentified from the third generation captive tree shrews: body surface: S. epidermidis(75%); oral cavity: N.mucosa(67%); anus: L. lactis(33%), E. coli(100%). These results indicate that S. epidermidis, N. mucosa, L. lactis and E. coli were major bacteria in tree shrews, whereas, S. aureus, M. luteus, K. gibsonii, E. faecalis and S. typhosa were species-specific flora. This study facilitates the future use of tree shrews as a standard experimental animal and improves our understanding of the relationship between endosymbionts and their hosts. | Gui LI Ren LAI Gang DUAN Long-Bao LYU Zhi-Ye ZHANG Huang LIU Xun XIANG | 2014 | Zoological Research2014，35，6： | 6 |
| 6 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 7 | Comparative Genomic Analysis of Enterovirus 71 Revealed Six New Potential Neurovirulence-associated Sites显示文摘在现在的学习,完全的染色体四普通(4/EV71/Wenzhou/CHN/2014, 15/EV71/Wenzhou/CHN/2014, 116/EV71/Wenzhou/CHN/2014,和 120/EV71/Wenzhou/CHN/2014 ) 并且二剧毒(11/EV71/Wenzhou/CHN/2014 和 109/EV71/Wenzhou/CHN/2014 ) enterovirus (EV71 ) 71 孤立被定序并且描述。他们是在长度的 7405 bp 并且属于 EV71 亚遗传型 C4 (C4a 簇) 。核苷酸顺序排列揭示了六个核苷酸变化( G P151 T P151 , G P199 P199 , G P261 T P261 , A P328 C P328 , G P422 P422 ,和 G P437 T P437 )在二剧毒在 IRES 元素的 5UTR 以内孤立。怒火和 FCE 的 RNA 第二等的结构预言显示普通孤立分享的类似的结构,它与那些不同剧毒孤立。而且, G P114 C P114 和 G P151 T P151 变化在剧毒孤立在 SL II 贡献了唯一的 RNA 第二等的结构的形成。而且, EV71 孤立的 82 的 nucleotide/amino 酸顺序排列显示了那六个地点(T P488 和 C 在 5UTR 的 P577 ;Asn 在 2A 的 P57 ;Ile 在 3C 的 P56 ;C P10 和 A 在 3UTR 的 P47 ) 潜在地与 EV71 的 neurovirulence 被联系。最后, 2A 的 3D 结构是类似的,而 VP1 和 3C 的结构是可变的。 | JIA Qing Jun CHEN Xin Yu LI De Zhou XU Juan Juan XU Zhi Gang DUAN Zhi Liang WEN Jin Sheng | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 8 | Polyoxometalates-engineered hydrogen generation rate and durability of Pt/CNT catalysts from ammonia borane显示文摘Heterogeneously catalyzed hydrolytic dehydrogenation of ammonia borane is a remarkable structure sensitive reaction. In this work, a strategy by using polyoxometalates(POMs) as the ligands is proposed to engineer the surface and electronic properties of Pt/CNT catalysts toward the enhanced hydrogen generation rate and durability. Three kinds of POMs, i.e., silicotungstic acid(STA), phosphotungstic acid(PTA)and molybdophosphoric acid(PMA), are comparatively studied, among which the STA shows positive effects on the catalytic activity and durability. A catalyst structure-performance relationship is established by a combination of kinetic and isotopic analyses with multiple characterization techniques, such as HAADF-STEM, EDS, Raman spectroscopy and XPS. It is shown that the STA compared to the other two POMs can increase the Pt binding energy and thus promote the reaction. The insights demonstrated here could open a new avenue for boosting the reaction by employing the POMs as the ligands to engineer the catalyst electronic properties. | Wenzhao Fu Chen Han Dali Li Wenyao Chen Jian Ji Gang Qian Weikang Yuan Xuezhi Duan Xinggui Zhou | 2020 | Journal of Energy Chemistry2020，29，2： | 5 |
| 9 | Implantable nerve guidance conduits:Material combinations,multi-functional strategies and advanced engineering innovations显示文摘Nerve guidance conduits(NGCs)have attracted much attention due to their great necessity and applicability in clinical use for the peripheral nerve repair.Great efforts in recent years have been devoted to the development of high-performance NGCs using various materials and strategies.The present review provides a comprehensive overview of progress in the material innovation,structural design,advanced engineering technologies and multi functionalization of state-of-the-art nerve guidance conduits NGCs.Abundant advanced engineering technologies including extrusion-based system,laser-based system,and novel textile forming techniques in terms of weaving,knitting,braiding,and electrospinning techniques were also analyzed in detail.Findings arising from this review indicate that the structural mimetic NGCs combined with natural and synthetic materials using advanced manufacturing technologies can make full use of their complementary advantages,acquiring better biomechanical properties,chemical stability and biocompatibility.Finally,the existing challenges and future opportunities of NGCs were put forward aiming for further research and applications of NGCs. | Yixin Yan Ruotong Yao Jingyuan Zhao Kaili Chen Lirong Duan Tian Wang Shujun Zhang Jinping Guan Zhaozhu Zheng Xiaoqin Wang Zekun Liu Yi Li Gang Li | 2022 | Bioactive Materials2022，7，5： | 4 |
| 10 | Soil loss tolerance in the black soil region of Northeast China显示文摘土壤损失忍耐(T) 是被容忍并且仍然允许经济地并且无止境地要支撑的庄稼生产率的高水平的年度土壤侵蚀的最大的率。在东北中国的黑土壤区域,一以经验为主地坚定, 200 的缺省 T | DUAN Xingwu XIE Yun LIU Baoyuan LIU Gang FENG Yanjie GAO Xiaofei | 2012 | Journal of Geographical Sciences2012，22，4： | 4 |
| 11 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 12 | Geochemical and Petrological Studies on the Early Carboniferous Sidingheishan Mafic-Ultramafic Iintrusion in the Southern Margin of the Central Asian Orogenic Belt,NW China显示文摘The Sidingheishan mafic-ultramafic intrusion is located in the eastern part of the Northern Tianshan Mountain, along the southern margin of the Central Asian Orogenic Belt in northern Xinjiang autonomous region of China. The Sidingheishan intrusion is mainly composed of wehrlite, olivine websterite, olivine gabbro, gabbro and hornblende gabbro. At least two pulses of magma were involved in the formation of the intrusion. The first pulse of magma produced an olivine-free unit and the second pulse produced an olivine-bearing unit. The magmas intruded the Devonian granites and granodiorites.An age of 351.4±5.8 Ma(Early Carboniferous) for the Sidingheishan intrusion has been determined by U-Pb SHRIMP analysis of zircon grains separated from the olivine gabbro unit. A U-Pb age of 359.2±6.4 Ma from the gabbro unit has been obtained by LA-ICP-MS. Olivine of the Sidingheishan intrusion reaches 82.52 mole% Fo and 1414 ppm Ni. On the basis of olivine-liquid equilibria, it has been calculated that the MgO and FeO included in the parental magma of a wehrlite sample were approximately10.43 wt% and 13.14 wt%, respectively. The Sidingheishan intrusive rocks are characterized by moderate enrichments in Th and Sm, slight enrichments in light REE, and depletions in Nb, Ta, Zr and Hf. The ε_(Nd)(t) values in the rock units vary from +6.70 to +9.64, and initial ^(87)Sr/^(86)Sr ratios range between 0.7035 and0.7042. Initial ^(206)Pb/^(204)Pb, ^(207)Pb/^(204)Pb and ^(208)Pb/^(204)Pb values fall in the ranges of 17.23-17.91,15.45-15.54 and 37.54-38.09 respectively. These characteristics are collectively similar to the Heishan intrusion and the Early Carboniferous subduction related volcanic rocks in the Santanghu Basin, North Tianshan and Beishan area. The low(La/Gd)_(PM) values between 0.26 and 1.77 indicate that the magma of the Sidingheishan intrusion was most likely derived from a depleted spinel-peridotite mantle.(Th/Nb)_(PM)ratios from 0.59 to 20.25 indicate contamination of the parental magma in the upper crust.Crystallization modeling methods suggest that the parental magma of the Sidingheishan intrusion was generated by flush melting of the asthenosphere and subsequently there was about 10 vol%contamination from a granitic melt. This was followed by about 5 vol% assimilation of upper crustal rocks. Thus, the high-Mg basaltic parental magma of Sidingheishan intrusion is interpreted to have formed from partial melting of the asthenosphere during the break-off of a subducted slab. | SUN Tao QIAN Zhuangzhi THAKURTA Joyashish YANG Shenghong XU Gang DUAN Jun GAO Bo WANG Jing | 2018 | Acta Geologica Sinica(English Edition)2018，92，3： | 3 |
| 13 | Fabrication of K-promoted iron/carbon nanotubes composite catalysts for the Fischer–Tropsch synthesis of lower olefins显示文摘K-promoted iron/carbon nanotubes composite(i.e., Fe K-OX) was prepared by a redox reaction between carbon nanotubes and K_2FeO_4followed by thermal treatments on a purpose as the Fischer–Tropsch catalyst for the direct conversion of syngas to lower olefins. Its catalytic behaviors were compared with those of the other two Fe-IM and Fe K-IM catalysts prepared by impregnation method followed by thermal treatments. The novel Fe K-OX composite catalyst is found to exhibit higher hydrocarbon selectivity,lower olefins selectivity and chain growth probability as well as better stability. The catalyst structureperformance relationship has been established using multiple techniques including XRD, Raman, TEM and EDS elemental mapping. In addition, effects of additional potassium into the Fe K-OX composite catalyst on the FTO performance were also investigated and discussed. Additional potassium promoters further endow the catalysts with higher yield of lower olefins. These results demonstrated that the introduction method of promoters and iron species plays a crucial role in the design and fabrication of highly active,selective and stable iron-based composite catalysts for the FTO reaction. | Xuezhi Duan Di Wang Gang Qian John C.Walmsley Anders Holmen De Chen Xinggui Zhou | 2016 | Journal of Energy Chemistry2016，25，2： | 3 |
| 14 | Dissolution-precipitation mechanism of self-propagating high-temperature synthesis of TiC-Cu cermets显示文摘The mechanism of self-propagating high-temperature synthesis (SHS) of TiC-Cu cermets was studied using a combustion front quenching method. Microstructural evolution in the quenched sample was observed using scanning electron microscope (SEM) with energy dispersive X-ray (EDX) spectrometry, and the combustion temperature was measured. The results showed that the com- bustion reaction started with local formation of Ti-Cu melt and could be described with the dissolution-precipitation mechanism, namely, Ti, Cu, and C particles dissolved into the Ti-Cu solution and TiC particles precipitated in the saturated Ti-Cu-C liquid solu- tion. The local formation of Ti-Cu melt resulted from the solid diffusion between Ti and Cu particles. | Guoqing Xiao Feng Duan Gang Zhang Quncheng Fan | 2007 | Journal of University of Science and Technology Beijing2007，14，6： | 3 |
| 15 | Thermotolerant and fireproof gel polymer electrolyte toward high-performance and safe lithium-ion battery显示文摘Poly(ethylene oxide)(PEO)and its derivatives based gel polymer electrolytes(GPEs)are severely limited in advanced and safe lithium-ion batteries(LIBs)owing to the intrinsically high flammability of liquid electrolytes and PEO.Directly adding flame retardants to the GPEs can suppress their flammability and thus improve the safety of LIBs,but results in deteriorative electrochemical performance.Herein,a novel GPE with chemically bonded flame retardant(i.e.diethyl vinylphosphonate)in cross-linked polyethylene glycol diacrylate matrix,featuring both high-safety and high-performance,is designed.This as-prepared GPE storing the commercial 1 mol L^(-1) LiPF6 electrolyte resists high temperature of 200℃and cannot be ignited as well as possesses a high ionic conductivity(0.60 m S cm^(-1))and good compatibility with lithium.Notably,the LiFePO_(4)/Li battery with this GPE delivers a satisfactory capacity of 142.2 m A h g^(-1) and a superior cycling performance with a capacity retention of 96.3%and a coulombic efficiency of close to 100%for 350 cycles at 0.2 C under ambient temperature.Furthermore,the battery can achieve steady charge–discharge for 100 cycles with a coulombic efficiency of 99.5%at 1 C under 80℃and run normally even at a high temperature of 150℃or under the exposure to butane flame.Differential scanning calorimetry manifests significantly improved battery safety compared to commercial battery systems.This work provides a new pathway for developing next-generation advanced LIBs with enhanced performance and high safety. | Man-Cheng Long Ting Wang Ping-Hui Duan You Gao Xiu-Li Wang Gang Wu Yu-Zhong Wang | 2022 | Journal of Energy Chemistry2022，31，2： | 3 |
| 16 | Lysosomal Exocytosis in Schwann Cells Contributes to Axon Remyelination显示文摘髓鞘形成是一个包括协同性的胞吐、内吞、mRNA转运和细胞骨架的动态变化的复杂过程。尽管髓鞘的异常在溶酶体贮积症中很常见,但对溶酶体在髓鞘形成和维持中所扮演的角色仍不清楚。本文发现Schwann细胞中的晚期内涵体/溶酶体包含大量的髓鞘蛋白P0,含量占超过一半的外周神经系统中的致密髓鞘的总蛋白并且在不同的刺激下表现出Ca2+依赖性的胞吐作用。Rab27a(一种将分泌溶酶体运输至细胞膜的小GTP酶)下调,极大地阻碍了Schwann细胞中的溶酶体胞吐作用,减少了再生坐骨神经的髓鞘形成。这些发现强调了Schwann细胞中溶酶体的新角色,提示调节Schwann细胞中的溶酶体胞吐作用在外周神经系统中有很重要的生理和病理意义。 | GANG CHEN ZHIJUN ZHANG ZHONGYA WEI QIONG CHENG XIA LI WEI LI SHUMIN DUAN AND XIAOSONG GU | 2012 | 神经损伤与功能重建2012，7，3： | 3 |
| 17 | Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China显示文摘Norovirus(No V)is a pathogen that commonly causes viral diarrhea in children.Studies indicate that No V recognizes human histo-blood group antigens(HBGAs)as cell attachment factors.In order to explore the correlation between of No V infection and HBGAs,a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. | SUN Xiao Man YAN Xiao Feng HE Zhi Gang Li Jing Xin GUO Ni Jun XU Zi Qian JIN Miao LI Dan Di ZHOU Yong Kang XIE Guang Cheng Pang Li Li ZHANG Qing LIU Na DUAN Zhao Jun | 2016 | Biomedical and Environmental Sciences2016，29，4： | 3 |
| 18 | Trafficking pathway between plasma membrane and mitochondria via clathrin-mediated endocytosis显示文摘Endocytosis is a basic cellular process that describes a form of active transport across the plasma membrane into the cell.The endocytic pathway consists of distinct membrane compartments;internalized molecules are delivered to early endosomes,and some of them are recycled back to the surface,whereas other molecules are sent to late endosomes and lysosomes for degradation.However,little is known about how mitochondria are involved in the endocytic pathway.Here,we report that FM dyes, membrane-impermeant fluorescent lipid probes,can traffic to mitochondria directly from the plasma membrane by clathrinmediated endocytosis.FM dye entry into mitochondria uses microtubule-dependent active transport,but the mechanism is different from the classical endocytic pathway.Hence,this study reveals a previously unrealized lipid trafficking pathway from the plasma membrane to mitochondria. | Zhongya Wei Wenfeng Su Huifang Lou Shumin Duan Gang Chen | 2018 | Journal of Molecular Cell Biology2018，10，6： | 2 |
| 19 | Pressure induced convergence of conduction bands in Al doped Mg_(2)Si: Experiment and theory显示文摘High-pressure and high-temperature(HPHT)synthesis provides an effective way to tune the band structure of materials and improve their electronic properties.To investigate the influence of synthesis pressure on electronic properties,Mg_(1.97)Al_(0.03)Si samples were synthesized using the HPHT method.The maximum effective mass 0.92me is obtained for the sample prepared with the synthesis pressure of 3 GPa,leading to the biggest Seebeck coefficient201.3 mV/K at room temperature.Meanwhile,the 3 GPa sample obtains the higher electron carrier concentration and electrical conductivity,resulting in nearly overall enhancement of power factor.The Density Functional Theory(DFT)calculations evidences that the Conduction Bands Minimum(CBM)can be tuned effectively by applied pressure and the convergence of the CBM leads to a larger effective mass of DOS,which are beneficial to the enhancement of power factors.These results indicate that high-pressure is a powerful tool to tune Mg_(1.97)Al_(0.03)Si band structures. | Jialiang Li Xiaolian Zhang Bo Duan Yunlong Cui Houjiang Yang Hongtao Wang Junchao Li Xiaojun Hu Gang Chen Pengcheng Zhai | 2019 | Journal of Materiomics2019，5，1： | 2 |
| 20 | Boron carbide boosted Fenton-like oxidation: A novel Fe(Ⅲ)/Fe(Ⅱ) circulation显示文摘The sluggish kinetics of Fe(Ⅱ)recovery in Fenton/Fenton-like reactions significantly limits the oxidation efficiency.In this study,we for the first time use boron carbide(BC)as a green and stable promotor to enhance the reaction of Fe(Ⅲ)/H_(2)O_(2) for degradation of diverse organic pollutants.Electron paramagnetic resonance analysis and chemical quenching/capturing experiments demonstrate that hydroxyl radicals(·OH)are the primary reactive species in the BC/Fe(Ⅲ)/H_(2)O_(2) system.In situ electrochemical analysis indicates that BC remarkably boosts the Fe(Ⅲ)/Fe(Ⅱ)redox cycles,where the adsorbed Fe(Ⅲ)cations were transformed to more active Fe(Ⅲ)species with a higher oxidative potential to react with H_(2)O_(2) to produce Fe(Ⅱ).Thus,the recovery of Fe(Ⅱ)from Fe(Ⅲ)is facilitated over BC surface,which enhancesOH generation via Fenton reactions.Moreover,BC exhibits outstanding reusability and stability in successive cycles and avoids the secondary pollution caused by conventional organic and metalliferous promotors.Therefore,metal-free BC boosting Fe(Ⅲ)/H_(2)O_(2) oxidation of organics provides a green and advanced strategy for water decontamination. | Peng Zhou Feng Cheng Gang Nie Yangyang Yang Kunsheng Hu Xiaoguang Duan Yongli Zhang Shaobin Wang | 2020 | Green Energy & Environment2020，5，4： | 2 |
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