2篇
您的检索式：作者名="Congjing Feng"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanical and antibacterial properties of tannic acid-encapsulated carboxymethyl chitosan/polyvinyl alcohol hydrogels显示文摘The objective of this study was to develop an effective,potential wound dressing,which was constructed with a composite hydrogel of poly(vinyl alcohol)(PVA),carboxymethyl chitosan(CMC)and tannic acid(TA)by cryogenic treatment and freeze-drying method.The as-prepared TA-crosslinked PVA/CMC hydrogels exhibited interconnected pore structure with the mean pore size of roughly 3.7��m.We found that the compressive strength and stiffness of composite hydrogel increased when the TA component was introduced.However,the PVA/CMC-TA hydrogel possessed obviously lower swell property than that of the TA-free PVA/CMC hydrogel.We also found that the TA addition significantly improved the antibacterial capacity of the as-prepared hydrogel.Moreover,the inhibition zone test showed that the antibacterial activity of PVA/CMC-TA against S.aureus bacteria was greater than that against E.coli.The biological results indicated that the PVA/CMC-TA hydrogel exhibited good cytocompatibility to natural human dermal fibroblasts.In summary,our PVA/CMC-TA composite hydrogel exhibited promising mechanical and antibacterial properties,which showed great potential application as wound healing materials. | Xiaofan Feng Xiuling Hou Congjing Cui Shibin Sun Sahiya Sadik Shaohua Wu Fang Zhou | 2021 | Engineered Regeneration2021，2，1： | 2 |
| 2 | The selective regulation of immune responses by matrix metalloproteinase MMP14 in Ostrinia furnacalis显示文摘Matrix metalloproteinases (MMPs) are crucial for tissue remodeling and immune responses in insects, yet it remains unclear how MMPs affect the various immune processes against pathogenic infections and whether the responses vary among insects. In this study, we used the lepidopteran pest Ostrinia furnacalis larvae to address these questions by examining the changes of immune-related gene expression and antimicrobial activity after the knockdown of MMP14 and bacterial infections. We identified MMP14 in O. furnacalis using the rapid amplification of complementary DNA ends (RACE), and found that it was conserved and belonged to the MMP1 subfamily. Our functional investigations revealed that MMP14 is an infection-responsive gene, and its knockdown reduces phenoloxidase (PO) activity and Cecropin expression, while the expressions of Lysozyme, Attacin, Gloverin, and Moricin are enhanced after MMP14 knockdown. Further PO and lysozyme activity determinations showed consistent results with gene expression of these immune-related genes. Finally, the knockdown of MMP14 decreased larvae survival to bacterial infections. Taken together, our data indicate that MMP14 selectively regulates the immune responses, and is required to defend against bacterial infections in O. furnacalis larvae. Conserved MMPs may serve as a potential target for pest control using a combination of double-stranded RNA and bacterial infection. | Kangkang Chen Shiqi Lu Jiahui Song Xiaoyi Dou Xiangyi Wei Xinyan Wang Xu Liu Congjing Feng | 2023 | Insect Science2023，30，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员