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| 1 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 2 | CUTE: constrained and unconstrained testing environment显示文摘 | Bongartz J Conn A R Gould N I M | 1995 | ACM Tran Math Software1995，，： | 1 |
| 3 | Reversible water- solubilization of single-walled carbon nanotubes by polymer wrapping显示文摘 | O'ConnelI M J BouI P Ericson L M | 2001 | Chem Phys Lett2001，342，34： | 1 |
| 4 | Meta-analysis of quality-of-life outcomes from physical activity interventions显示文摘 | CONN V S HAFDAHL A R BROWN L M | 2009 | Nurs Res2009，58，3： | 1 |
| 5 | Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells 显示文摘 | Rodgers G M Conn M T | 1990 | Blood1990，75，： | 1 |
| 6 | Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor显示文摘 | Conn G Bayne M L Soderman D | 1990 | Proc Natl Acad Sci USA1990，87，7： | 1 |
| 7 | Intestinal steatosis in the farm reared sea bass Dicentrarchus labrax显示文摘 | Deplano M Connes R Diaz J P | 1989 | Dis Aquac Org1989，6，： | 1 |
| 8 | The anticoagulation fac-tor protein S and its relative,Gas6,are ligands for the Ty-ro 3/Axl family of receptor tyrosine kinases显示文摘 | Stitt TN Conn G Gore M | 1995 | Cell1995，80，4： | 1 |
| 9 | Purification and characterization of a naturally occurring vascular endothelial growth factor placenta growth factor heterodimer显示文摘 | Disalvo J Bayne M L Conn G | 1995 | J Biol Chem1995，270，13： | 1 |
| 10 | Effects of germanium(Ge) on the silica spicules of the marine sponge Suberites domuncula:transformation of the spicule type显示文摘 | Simpson TL Gil M Connes R | 1985 | J Morphol1985，183，： | 1 |
| 11 | Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling显示文摘 | Noetzel M J Jones CK Conn PJ | 2012 | Discov Med2012，14，： | 1 |
| 12 | Metabotropic glutamate receptors : physiology, pharmacology, and disease 显示文摘 | Niswender C M Conn P J | 2010 | Annu Rev Pharmacol Toxicol2010，50，： | 1 |
| 13 | C U TE: Constrained and Unconstrained Testing Environments 显示文摘 | BONGARTZ I CONN A R GOULD N I M | 1995 | ACM Transactions on Mathematical Software1995，21，1： | 1 |
| 14 | Convergence of Quasi-Newton matrices generated by the symmetric rank one update显示文摘 | Conn A R Gould N I M Toint P L | 1991 | Mathematical Programming1991，50，： | 1 |
| 15 | Intestinal steatosis in the farm reard sea bass Dicentrarchus labrax显示文摘 | Deplano M Connes R Diaz J P | 1989 | Dis Aquac Org1989，6，： | 1 |
| 16 | Global convergence of a class of trust region algorithms for optimization with simple bounds显示文摘 | Conn A R Gould N I M Toint P L | | 0，，02： | 1 |
| 17 | Functional dichotomy in the 16S rRNA (mlA1408) methyltransferase family and control of catalytic ac- tivity via a novel tryptophan mediated loop reorganization 显示文摘 | Witek M A Conn G L | 2016 | Nucleic Acids Res2016，44，1： | 1 |
| 18 | Petroleum resources of the Mackenzie Delta and Beaufort Sea显示文摘 | Dixon J Morrel G R Dietrich J R Taylor G C Procter R M Conn R F Dallair S M Christie J A | 1994 | Geological Survey of Canada Bulletin1994，474，： | 1 |
| 19 | General plasmids for produ cing RNA in vitro transcripts with homogeneous ends 显示文摘 | Walker S C Avis J M Conn G L | 2003 | Nucleic Acids Res2003，31，15： | 1 |
| 20 | Intestinal steatosis in the farm reard sea bass Dicentrarchus labrax显示文摘 | Deplano M Connes R Diaz J P | 1989 | Dis Aquac Org1989，6，： | 1 |
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