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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms显示文摘AIM To clarify the association of malignancy with mesenteric panniculitis-like changes on computed tomography(CT).METHODS All abdominal CT scans performed at North Shore University HealthS ystem showing mesenteric panniculitis from January 2005 to August 2010 were identified in the Radnet(Rad Net Corporation, Los Angeles, CA) database. Patients with a new or known diagnosis of a malignancy were included for this analysis. Longitudinal clinical histories were obtained from electronic medical records.RESULTS In total, 147794 abdominal CT scans were performed during the study period. Three hundred and fiftynine patients had mesenteric panniculitis(MP)-like abnormalities on their abdominal CT. Of these patients, 81 patients(22.6%) had a known history of cancer at the time of their CT scan. Nineteen(5.3%) had a new diagnosis of cancer in concurrence with their CT, but the majority of these(14/19, 74%) were undergoing CT as part of a malignancy evaluation. Lymphomas were the most common cancers associated with MPlike findings on CT(36 cases, 36%), with follicular lymphoma being the most frequent subtype(17/36). A variety of solid tumors, most commonly prostate(7) and renal cell cancers(6) also were seen. CT follow up was obtained in 56 patients. Findings in the mesentery were unchanged in 45(80%), worsened in 6(11%), and improved in 5 patients(9%). Positron emission tomography(PET) scans performed in 44 patients only showed a positive uptake in the mesenteric mass in 2 patients(5%). CONCLUSION A new diagnosis of cancer is uncommon in patients with CT findings suggestive of MP. MP-like mesenteric abnormalities on CT generally remain stable in patients with associated malignancies. PET scanning is not recommended in the evaluation of patients with mesenteric panniculitis-like findings on CT. | Eli D Ehrenpreis Grigory Roginsky Richard M Gore | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 3 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 4 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 5 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 6 | Synthesis of putative intermediates in the biosynthesis of the kinamycin antibiotics: total synthesis of phenanthroviridn aglycon and related compounds显示文摘 | GORE M P GOULD S J WELLER D D | 1992 | J Org Chem1992，57，： | 2 |
| 7 | Functional magnetic resonance imaging in a visual oddball task显示文摘 | McCarthy G Luby M Gore JC | 1996 | Neuroimage1996，3，： | 2 |
| 8 | Enhanced capacities and selectivities for cholesterol in aqueous media by molecular imprinting role of novel cross-linkers 显示文摘 | Gore M A Karmalkar R N GKulkarni M | 2004 | Journal of Chromatography B2004，804，： | 1 |
| 9 | Reagentless pH - based biosensing using a fluorescently - labelled dextran coentrapped with a hydrolytic enzyme in solgel derived nanocomposite films显示文摘 | GULCEV M D GORING L G GILLIAN R M | 2002 | Anal Chim Acta2002，457，1： | 1 |
| 10 | Structure, expression, and activity of Tyro3,a neural adhesion-related receptor tyrosine kinase 显示文摘 | Lai C Gore M Lemke G | 1994 | Oncogene1994，9，： | 1 |
| 11 | Topotecan versus paclitaxel for the treatment of reccurent epithelial ovarian cancer显示文摘 | GORE M CARMICHAEL J GORDON A | 1997 | Clin Oncol1997，15，6： | 1 |
| 12 | Status and prospects of associa- tion mapping in plants显示文摘 | Zhu C M Gore E S Buekler | 2008 | Plant Genome2008，1，： | 1 |
| 13 | Study on ultrasound assisted precipitation of CL-20 and its effect on morphology and sensitivity显示文摘 | Sivabalan R Gore G M Nair U R | 2007 | Journal of Hazardous Materials2007，139，： | 1 |
| 14 | HAZEXPERT: an integrated expert system to support hazard analysis in process plant design 显示文摘 | Goring M Schecker H G | 1993 | Computers &Chemical Engineering1993，17，： | 1 |
| 15 | Experience with independent radiological review during a topotecan trail in ovarian cancer显示文摘 | GWYTHER S BOLIS G GORE M | 1997 | Ann Oncol1997，8，5： | 1 |
| 16 | Lysosomes in cell death 显示文摘 | Guicciardi M E Leist M Gores G J | 2004 | Oncogene2004，23，16： | 1 |
| 17 | Clinical evidence for topotecan-paclitaxel non-cross-resistance in ovarian cancer 显示文摘 | Huinink WB Garmichael J | 2001 | J Clin Oncol2001，19，7： | 1 |
| 18 | A phase II study of docetaxel(Taxotere,DXT) in patients with advanced ovarian cancer relapsing 》12 months after their last platinum course显示文摘 | Piccart MT Gore M Van Oosterom AT | 1995 | Pro Am Soc Clin Oncol1995，14，： | 1 |
| 19 | Endurance training altars antioxidant enzyme gene expression in rat skeletal muscle显示文摘 | Gore M Fiebig R Hollander J | 1998 | Can J Physiol Pharmacol 1998 Dec1998，76，12： | 1 |
| 20 | Spatio-temporal Data Types: An Approach to Modeling and Querying Moving Objects in Databases显示文摘 | Erwig M GOring R H Schneider M et el | 1999 | GeoInformatica1999，3，3： | 1 |
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