|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial显示文摘 | Thomas E Hutson Vladimir Lesovoy Salman Al-Shukri Viktor P Stus Oleg N Lipatov Angel H Bair Brad Rosbrook Connie Chen Sinil Kim Nicholas J Vogelzang | 2013 | Lancet Oncology2013，，13： | 2 |
| 2 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 3 | Chlorinated polycyclic aromatic hydrocarbons:method of analysis and their occurrence in urban air显示文摘 | Ulrika L Nilsson Conny E | 1993 | Environ Sci Technol1993，27，： | 1 |
| 4 | Delay in disclosure of childhood rape: results from a national survey显示文摘 | Daniel W Smith Elizabeth J Letourneau Benjamin E Saunders Dean G Kilpatrick Heidi S Resnick Connie L Best | 2000 | Child Abuse & Neglect2000，，2： | 1 |
| 5 | Meta - study of qualitative health research : A practi- cal guide to meta -analysis and meta- synthesis 显示文摘 | BARBARA L PATERSON SALLY E THORNE CONNIE CAN- AM ET AL | 2003 | International Journal of Nursing Studies2003，2，40： | 1 |
| 6 | Discovery and characterization of a selective, nonpeptidyl thrombopoietin re- ceptor agonist显示文摘 | Connie L Millera E DeLormeb E | 2005 | Exp Hematol2005，33，1： | 1 |
| 7 | Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnor- malities in carotid structure and function 显示文摘 | Elaine MU Thomas RK Connie E | 2009 | Circulation2009，119，： | 1 |
| 8 | Selective e numeration of Bifidobacterium bifidum, Enterococcus faecium, and streptomycin-r esistant Lactobacillus acidophilus from a mixed probiotic product显示文摘 | Melissa L Calicchia Connie I E Wang Takehiro Nomura | 1993 | Food pro tection1993，56，： | 1 |
| 9 | Isolation and classification of polycyclic aromatic nitrogen heterocyclic compounds 显示文摘 | CONNY E O | 1988 | Fuel1988，67，： | 1 |
| 10 | A case of contagious ec- thyma(Orf virus) in a nonmanipulated laboratory Dorset sheep (Owls aries) 显示文摘 | Gwynne E Kinley Connie W | 2013 | Vet Med2013，7，： | 1 |
| 11 | Differential effect of erythropoietin and GM-CSF on megakaryocytopoiesis from primitive bone marrow cells in serum-free conditions显示文摘 | Jose E Connie L Erickson M | 1997 | Stem Cells1997，15，： | 1 |
| 12 | Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trial显示文摘 | Robert J Motzer Bernard Escudier Piotr Tomczak Thomas E Hutson M Dror Michaelson Sylvie Negrier Stephane Oudard Martin E Gore Jamal Tarazi Subramanian Hariharan Connie Chen Brad Rosbrook Sinil Kim Brian I Rini | 2013 | Lancet Oncology2013，，： | 1 |
| 13 | Chlorinated polycyclic aromatic hydrocarbons:method of analysis and their occurrence in urban air显示文摘 | Ulrika L Nilsson Conny E | 1993 | Environ Sci Technol1993，27，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员