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| 1 | Do statins reduce hepatitis C RNA titers during routine clinical use?显示文摘AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral titers.RESULTS: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy. | Kimberly A Forde Connie Law Rose O’Flynn David E Kaplan | 2009 | World Journal of Gastroenterology2009，15，40： | 2 |
| 2 | A contactless biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representation2012，23，7： | 1 |
| 3 | Diatom assemblages and their associated environmental factors in upland peat forest rivers显示文摘 | Connie O'Driscoll Elvira de Eyto Michael Rodgers Mark O'Connor Zaki-ul-Zaman Asam Liwen Xiao | 2012 | Ecological indicators2012，18，： | 1 |
| 4 | A contactless biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representation2012，23，7： | 1 |
| 5 | Ethical climate, ethics stress, and the job satisfac- tion of nurses and social workers in the United States显示文摘 | ULRICH CONNIE PATRICIA O' DONELL CAROL TAY- LOR | 2007 | Social Science & Medicine2007，65，8： | 1 |
| 6 | Determination of or- ganophosphorous flame reretardants in fish tissues by ma- trix solid- phase dispersion and gas chromatography 显示文摘 | Luca C Anna L P Conny O | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
| 7 | Touch-less palm print biometrics: Novel design and implementation 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2008 | Image and Vision Computing2008，26，12： | 1 |
| 8 | Personal recognition using multi-angles gait sequences显示文摘 | TEE Connie KAH O G M BENG J T A | 2011 | Communications in Computer and Information Science2011，189，2： | 1 |
| 9 | A contact- less biometric system using multiple hand features 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2012 | Journal of Visual Communication and Image Representa- tion2012，23，7： | 1 |
| 10 | Determina lion of organophosl?horous flame retardants in fisb lis sues by matrix solid phase dispersion and gas chroma tography显示文摘 | LUCA C ANNA L P CONNY O | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
| 11 | Hybridization and genetic variation in Danish populations of European crabapple ( Malus sylvestris ) 显示文摘 | Anders S L Conny B A Ditte C O | 2006 | Tree Genetics & Ge- nomes2006，2，： | 1 |
| 12 | Touch-less palm print biometrics: Novel design and implementation 显示文摘 | MICHAEL G K O CONNIE T TEOH A B J | 2008 | Image and Vision Compu- ting2008，26，12： | 1 |
| 13 | Determination of or- ganophosphorous flame retardants in fish tissues by ma- trix solid-phase dispersion and gas chromatography显示文摘 | Luca C Anna L P Conny O | 2010 | Anal Bioanal Chem2010，397，3： | 1 |
| 14 | A contacfless biometric system using multiple hand features显示文摘 | G K O Micheal T Connie A B J Teoh | 2012 | Journal of Visual Commu- nication and Image Representation2012，23，7： | 1 |
| 15 | Cloning of rat telomer-ase catalytic subunit functional domains,reconstitution of telom-erase activity and enzymatic profile of pig and chicken tissues显示文摘 | Stephen C H Lee L O Connie P N | 2003 | Life Sciences2003，73，21： | 1 |
| 16 | 8, 9-Dihydroxy- 1, 2, 3, 11b-tetrahydrochromenoisoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms显示文摘 | Russell A G Mechelle M L Connie O V | 2004 | Bioorganic & Medicinal Chemistry2004，12，： | 1 |
| 17 | Ethical climate,ethics stress,and the job satisfaction of nurses and social workers in the United States显示文摘 | CONNIE ULRICH PATRICIA O' DONNELL CAROL TAY-LOR etc | 2007 | Social Science & Medicine2007，，8： | 1 |
| 18 | Touch-less palmprint bio- metrics: novel design and implementation 显示文摘 | G K O Michael T Connie A B J Teoh | 2008 | Image Vision and Computing2008，26，12： | 1 |
| 19 | Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues显示文摘 | Stephen C H Lee L O Connie P N | 2003 | Life Sciences2003，73，： | 1 |
| 20 | Kinectin anchors the translation elongation factor-1 to the endoplasmic reticulum显示文摘 | Lee-Lee O Connie P Andrea H | 2003 | Biol Chem2003，278，32： | 1 |
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