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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Space charge suppression of electrostatic induction spray charging显示文摘 | Robert Cooke J Steven C Cooper | 1997 | J of Electrostatics1997，4041，： | 1 |
| 3 | A Spark-generated Bubble Model with Semi-empirical Mass Transport 显示文摘 | COOK J A GLEESON A M ROBERTS R M | 1997 | J Acoust Soc Am1997，101，： | 1 |
| 4 | Gel electrophoresis for the identification of plant varieties显示文摘 | Cooke J Robert | 1995 | Journal of Chromatography A1995，698，1： | 1 |
| 5 | The Energy Partition of Underwater Sparks 显示文摘 | ROBERTS R M COOK J A ROGERS R L | 1996 | J Acoust Soc Am1996，99，： | 1 |
| 6 | An estimate of rotavirus vaccine efficacy following an outbreak of rotavirus gastroenteritis in Central Australia 显示文摘 | Graham J Cook H Roberts C | 2008 | Northern Territory Dis Control Bull2008，15，1： | 1 |
| 7 | The energy partition of underwater sparks显示文摘 | Roberts R Cook J Gleeson A | 1996 | Acoust1996，99，： | 1 |
| 8 | Electrically calibrated pyro- electric op tical-radiation detector 显示文摘 | Robert J Phelan Jr and A R Cook | 1973 | Appl Opt1973，12，10： | 1 |
| 9 | Response to Mallet et al., ‘Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients’显示文摘 | Lucy J Garvey Emma C Thomson Josephine Lloyd Graham S Cooke Robert D Goldin Janice Main | 2007 | AIDS2007，，11： | 1 |
| 10 | Three- dimensional seismic geomorphology of a deep-water slope- channel system: the sequoia field, offshore west nile delta, egypt显示文摘 | Cross Nigel E Alan C Cook Robert J | 2009 | AAPG Bulletin2009，93，： | 1 |
| 11 | Sequence and analysis ofchromosome 3 of the plant Arabidopsis thaliana显示文摘 | Salanoubat M Lemcke K Rieger M Ansorge W Unseld M Fartmann B Vaile G Blocker H Pcrez-Alonso M Obennaier B Delseny M Boutry M Grivell L A Mache R Puigdomenech P De Simone V Choisne N Artiguenave F Robert C Brottier P Wincker P Cattolico L Weissenbach J Saurin W Quetier F Schafer M Mu||er-Auer S Gabel C Fuchs M Benes V Wurmbach E Drzonek H Erfle H Jordan N Bangert S Wiedelmann R Kranz H Voss H Holland R Brandt P Nyakatura G Vezzi A D' Angelo M Pallavicini A Toppo S Simionati B Conrad A Homischer K Kauer G Lohnert T H Nordsiek G Reichelt J Scharfe M Schon O Bargues M Terol J Climent J Navarro P CoUado C Perez-Perez A Ottenwalder B Duchemin D Cooke R Laudie M Berger-Llauro C Pumelle B Masuy D de Haan M Maarse A C Alcaraz J P Cottet A Casacuberta E Monfort A Argiriou A Flores M Liguori R Vitale D Mannhaupt G Haase D Schoof H Rudd S Zaccaria P Mewes H W Mayer K F Kaul S Town C D Koo H L Tailon L J Jenkins J Rooney T Rizzo M Waits A Utterback T Fujii C Y Shea T P Creasy T H Haas B Maiti R Wu D Peterson J Van Aken S Pal G Militscher J Sellers P Gill J E Feldblyum T V Preuss D Lin X Nierman W C Salzberg S L White O Venter J C Fraser C M Kaneko T Nakamura Y Sato S Kato T Asamizu E Sasamoto S Kimura T Idesawa K Kawashiraa K Kishida Y Kiyokawa C Kohara M Matsumoto kl Matsuno A Muraki A Nakayama S Nakazaki N Shinpo S Takeuchi C Wada T Watanabe A Yamada M Yasuda M Tabata S | 2000 | Nature2000，408，6814： | 1 |
| 12 | Space charge suppression of electrostatic-induction spray charging显示文摘 | ROBERT COOKE J STEVEN C | 1997 | Journal of Electrostatics1997，4041，： | 1 |
| 13 | The energy partition of underwater sparks显示文摘 | Roberts R Cook J Gleeson A | 1996 | J Acoust Soc Am1996，99，： | 1 |
| 14 | Health-related quality-of-life and health-utility reporting in critical care显示文摘Mortality is a well-established patient-important outcome in critical care studies.In contrast,morbidity is less uniformly reported(given the myriad of critical care illnesses and complications of each)but may have a common end-impact on a patient’s functional capacity and health-related quality-of-life(HRQoL).Survival with a poor quality-of-life may not be acceptable depending on individual patient values and preferences.Hence,as mortality decreases within critical care,it becomes increasingly important to measure intensive care unit(ICU)survivor HRQoL.HRQoL measurements with a preference-based scoring algorithm can be converted into health utilities on a scale anchored at 0(representing death)and 1(representing full health).They can be combined with survival to calculate quality-adjusted life-years(QALY),which are one of the most widely used methods of combining morbidity and mortality into a composite outcome.Although QALYs have been use for health-technology assessment decision-making,an emerging and novel role would be to inform clinical decision-making for patients,families and healthcare providers about what expected HRQoL may be during and after ICU care.Critical care randomized control trials(RCTs)have not routinely measured or reported HRQoL(until more recently),likely due to incapacity of some patients to participate in patient-reported outcome measures.Further differences in HRQoL measurement tools can lead to non-comparable values.To this end,we propose the validation of a gold-standard HRQoL tool in critical care,specifically the EQ-5D-5L.Both combined health-utility and mortality(disaggregated)and QALYs(aggregated)can be reported,with disaggregation allowing for determination of which components are the main drivers of the QALY outcome.Increased use of HRQoL,health-utility,and QALYs in critical care RCTs has the potential to:(1)Increase the likelihood of finding important effects if they exist;(2)improve research efficiency;and(3)help inform optimal management of critically ill patients allowing for decision-making about their HRQoL,in additional to traditional health-technology assessments. | Vincent Issac Lau Jeffrey A Johnson Sean M Bagshaw Oleksa G Rewa John Basmaji Kimberley A Lewis M Elizabeth Wilcox Kali Barrett Francois Lamontagne Francois Lauzier Niall D Ferguson Simon J W Oczkowski Kirsten M Fiest Daniel J Niven Henry T Stelfox Waleed Alhazzani Margaret Herridge Robert Fowler Deborah J Cook Bram Rochwerg Feng Xie | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
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