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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 3 | The long term proghostic significance of oestrogen receptor analysis in early carcinoma of the breast显示文摘 | Winstanley J Cooke T George W D | 1991 | Br J Cancer1991，64，1： | 1 |
| 4 | Expression of the cyclin dependent kinase inhibitor p27 in keratocanthoma显示文摘 | HU W COOK T OH C W | 2000 | J Am Acad Dermatol2000，42，： | 1 |
| 5 | Production of the alkaloid swainsonine by a fungal endosymbiont of the ascomycete order chaetothyriales in the host Ipomoea carnea显示文摘 | COOK D BEAULIEU W T MOTT I W | 2013 | Journal of Agricultural and Food Chemistry2013，61，16： | 1 |
| 6 | Isolation and characterization of a cDNA clone encoding rat 5- lipoxygenase显示文摘 | BALCAREK J M THEISEN T W COOK M N | 1988 | J Biol Chem1988，263，13： | 1 |
| 7 | Hydrocarbon potential of the Barnett Shale (Mississippian) Delaware Basin, West Texas and Southeastem New Mexico 显示文摘 | Kinley T J Cook L W Breyer J A | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 8 | Enhanced in- cidence of legabnormalies in reovirus WVU2937 - infected chickens fedvarious dietary levels of select- ed vitamins显示文摘 | Cook M E Sppinger W T Hebert J A | 1983 | Avian Diseases1983，28，3： | 1 |
| 9 | DNA marker analysis detects multiple maternity and paternity in single brood of the lesser snow goose 显示文摘 | Quinn T W Quinn J S Cooke F | 1987 | Nature1987，326，： | 1 |
| 10 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 11 | Defect in peroxisome prol- iferator-activated receptor-inducible fatty acid oxidation deter- mines the severity of hepatic steatosis in responseto fasting显示文摘 | Hashimoto T Cook W S Qi C | 2000 | J Biol Chem2000，275，28： | 1 |
| 12 | Administration of a com- mercial imnmnostinmlant preparation ,ecoactivaTM as a feed supplement en- hances macrophage respiratory burst and the growth rate of snapper (pagrus u,ratus ,sparidae (bloch and schneider))in winter显示文摘 | Cook M T Hayball P J Hutchinson W | 2003 | Fish & shellfish immunol- ogq2003，14，4： | 1 |
| 13 | Positive interactions among alpine plants increase with stress显示文摘 | Callaway R M Brooker R W Choler P Kikvidze Z Lortie C J Michalet R Paolini L Pugnaire F I Newingham B Asche- houg E T Armas C Kikodze D Cook B J | 2002 | Nature2002，417，： | 1 |
| 14 | Comment on “A reservoir of nitrate beneath desert soils”显示文摘 | JACKSON R B BERTHRONG S T COOK C W | 2004 | Science2004，304，5667： | 1 |
| 15 | Frictional effects on the volurnetric strain of sandstone 显示文摘 | NIHEI K T HILBERT L B COOK N G W NAKAGAWA S MYER L R | 2000 | International Journal of Rock Mechanics and Mining Sciences2000，37，12： | 1 |
| 16 | Photoinduced plasticity in cross-linked polymers 显示文摘 | Scott T F Schneider A D Cook W D et at | 2005 | Science2005，308，5728： | 1 |
| 17 | Hydrocarbon potential of the Barnett shale(Mississippian),Delaware basin,west Texas and southeastern New Mexico显示文摘 | Kinley T J Cook W L Breyer A J | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 18 | 显示文摘 | Briand G G Cooke M W Cameron T S Farrell H M Burchell T J Aquino M A S | 2001 | Inorg Chem2001，40，： | 1 |
| 19 | Hydrocarbon po tential of the Barnett shale(Mississippian), Delaware Basin, west Texas and southeastern New Mexico显示文摘 | Kinley T J Cook L W Breyer J A | 2008 | AAPG Bulle tin2008，92，8： | 1 |
| 20 | Effects of age and sedentary lifestyle on skeletal muscle NF-kappa B signaling in men显示文摘 | Buford T W Cooke M B Manini T M | 2010 | J Gerontol A Biol Sci Med Sei2010，65，5： | 1 |
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