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| 1 | Nephrotoxicity in cancer treatment:An overview显示文摘Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment.The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites,which occurs by glomerular filtration and tubular secretion.Chemotherapeutic agents,both conventional cytotoxic agents and molecularly targeted agents,can affect any segment of the nephron including its microvasculature,leading to many clinical manifestations such as proteinuria,hypertension,electrolyte disturbances,glomerulopathy,acute and chronic interstitial nephritis,acute kidney injury and at times chronic kidney disease.The clinician should be alert to recognize several factors that may maximize renal dysfunction and contribute to the increased incidence of nephrotoxicity associated with these drugs,such as intravascular volume depletion,the associated use of nonchemotherapeutic nephrotoxic drugs(analgesics,antibiotics,proton pump inhibitors,and bonetargeted therapies),radiographic ionic contrast media or radiation therapy,urinary tract obstruction,and intrinsic renal disease.Identification of patients at higher risk for nephrotoxicity may allow the prevention or at least reduction in the development and severity of this adverse effect.Therefore,the aim of this brief review is to provide currently available evidences on oncologic drug-related nephrotoxicity. | Maria Luísa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio FranÇa da Silva Anelise Costa dos Santos Botelho Fabrício Freire de Melo | 2020 | World Journal of Clinical Oncology2020，11，4： | 4 |
| 2 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | Frequent somatic mutations and homozygous of the P16(MTS1) gene in pancreatic adenocarcinoma显示文摘 | Hahn SA da Costa LT | 1994 | Nat Genet1994，8，： | 1 |
| 5 | BDNF blocks easpase-3 acti-ration in neonatal hypoxia ischemia显示文摘 | Han BH D Costa A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 6 | Immobilization of catalase from Bacillus SF on alumina for the treatment of textile bleaching effluents显示文摘 | Costa SA Tzanov T Paar A | | 0，，： | 1 |
| 7 | Shotgun proteo- mics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte eholinergic stimulation 显示文摘 | Moore NH Costa LG Shaffer SA | 2009 | J Neurochem2009，108，4： | 1 |
| 8 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia显示文摘 | Han BH D' Costa A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 9 | Tuning of fractional PID controllers with Ziegler-Nichols-type rules 显示文摘 | VALERIO D SA DA COSTA J | 2006 | Signal Processing Journal2006，86，10： | 1 |
| 10 | Serial testing with theinterferon-gamma release assay in Portuguese healthcare workers显示文摘 | Torres Costa J Silva R Sa R | 2011 | Int Arch Occup Environ Health2011，84，46： | 1 |
| 11 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia显示文摘 | Han BH D' Costa A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 12 | Development of Effervescent Tablets Containing Benznidazole Complexed with Cyclodextrin显示文摘 | MAXIMIANO F P COSTA G H Y DE SA BARRETO L C L | 2011 | Journal of Pharmacy and Pharmacology2011，63，6： | 1 |
| 13 | Recycling of textile bleaching effluents for dyeing using immobilized catalase 显示文摘 | Costa SA Tzanov T Carneiro F | 2002 | Biotechnology Let- ters2002，24，3： | 1 |
| 14 | Immobilization of catalases from Bacillus SF on alumina for the treatment of textile bleaching effluents 显示文摘 | Costa SA Tzanova T Paar A | 2001 | Enzyme and Microbial Technology2001，28，910： | 1 |
| 15 | Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma显示文摘 | Caldas C Hahn SA da Costa LT | 1994 | Nat Genet1994，8，1： | 1 |
| 16 | Frequent somaticmutation and bomozygous deletions of the MTSI gene in pan creatic adenocarcinoma 显示文摘 | Caldas C Halm SA Costa D | 1994 | Nature Geret1994，8，1： | 1 |
| 17 | Identifying digital and fractional transfer functions from a frequency response显示文摘 | DUARTE Valerio JOSE Sa da Costa | 2011 | International Journal of Control2011，84，3： | 1 |
| 18 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia显示文摘 | Han BH D'Costa A Back SA | 2000 | Neurobiol Dis2000，7，1： | 1 |
| 19 | Spontaneous Coronary Artery Dissection with Clinical Presentation of Acute Myocardial Infarction显示文摘 | Taísa Godoy Guzzela Luciano de Siqueira Bracci Júnior Mauro Rogério de Barros Wanderley Júnior Sandra Helena Gonsalves de Andrade Mauro Cosme Gomes de Andrade Raony Previtali Paniquar Izabela Guimaraes Falcao Alves Nayrelle de Alencar Ferreira Gomes Jandir Ferreira Gomes Júnior Marcela Lopes Muniz de Andrade Renata London Rodrigues Diego Silveira da Costa Lucila Buriasco de Oliveira Amanda Ribeiro Letícia Trad Martins Costa Diego Braga Filartiga Reiby Caetano Mustafá | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 20 | BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia 显示文摘 | Hee Han B D' Costa A Back SA | 2000 | Neurobio Dis2000，7，1： | 1 |
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