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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Effect of focused and radial extracorporeal shock wave therapy on equine bone microdamage显示文摘 | Da Costa Gomez TM Radtke CL Kalscheur VL | 2004 | Vet Surg2004，33，1： | 1 |
| 3 | Tobacco use and control:determi-nants of consumption, intervention strategies, and the role of the to- bacco industry显示文摘 | da Costa e Silva VL Fishburn B | 2004 | Toxicology2004，198，13： | 1 |
| 4 | Serotyping and evaluation of the virulence in mice of Streptococcus suis strains insolated from diseased pigs显示文摘 | Costa AT Lobato FC Abreu VL | 2005 | Rev Inst Med Trop Sal Paulo2005，47，2： | 1 |
| 5 | Hypermethylation of Cyclin D'2 is associated with loss of mRNA expression and tumor de- velopment in prostate cancer 显示文摘 | I-lenrlque R Costa VL Cerveira N | 2006 | J Mol Med (Berl)2006，84，： | 1 |
| 6 | Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors显示文摘 | Costa VL Henrique R Ribeiro FR | 2007 | BMC Cancer2007，7，： | 1 |
| 7 | Gene methylation profiles of normal mucosa,and benign and malignant colorectal tumors identify early onset markers显示文摘 | Ahlquist T Lind GE Costa VL | 2008 | Mol Cancer2008，7，： | 1 |
| 8 | Effeet of focused and radial extraeorporeal shock wave therapy on equine bone microdamage显示文摘 | Da Costa Gomez TM Radtke CL Kalscheur VL | 2004 | Vet Surg2004，33，1： | 1 |
| 9 | Clinical outcome of neonatal bacterial meningitis according to birth weight 显示文摘 | Krebs VL Costa GA | 2007 | Arq Neuropsiquiatr2007，65，4： | 1 |
| 10 | Epigenetic regulation of EFEMP1 in prostate cancer: biological relevance and clinical pothential显示文摘 | Almedia M Costa VL Costa NR | 2014 | JCellMolMed2014，18，11： | 1 |
| 11 | Gene methylation profiles of normal mucosa,and benign and malignant colorectal tumors identify early onset markers显示文摘 | Ahlquist T Lind GE Costa VL | | 0，，： | 1 |
| 12 | Quantitative pro motermethylation analysis of multiple cancer related genes in renalcelhumors显示文摘 | Costa VL Henrique R Ribeiro FR | 2007 | BMCCancer2007，7，： | 1 |
| 13 | Three epigenetic bi-omarkers,GDF15,TMEFF2,and VIM,accurately predict blad-der cancer from DNA-based analyses of urine samples显示文摘 | Costa VL Henrique R Danielsen SA | 2010 | ClinCancer Res2010，16，23： | 1 |
| 14 | 显示文摘 | Vanesa Garcl 'a-Pacios Vl 'ctor Costa | 2010 | International Jour- nal of Adhesion&Adhesives2010，30，6： | 1 |
| 15 | Gene methylation profiles of normal mucosa, and benign and malignant colo- rectal tumors identify early onset markers显示文摘 | Ahlquist T Lind GE Costa VL | 2008 | Mol Cancer2008，7，： | 1 |
| 16 | Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers显示文摘 | Ahlquist T Lind GE Costa VL | 2008 | Mol Cancer2008，7，： | 1 |
| 17 | TCF21 and PCDHI7 methylation: an innovative panel ofbiomarkers for a simultaneous detection of urological cancers显示文摘 | Costa VL Henrique R Danielsen SA | 2011 | Epigenetics2011，6，9： | 1 |
| 18 | Cysteine-rich secretory protein-3 ( CRISP3 ) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene 显示文摘 | Ribeiro FR Paulo P Costa VL | 2011 | PLoS One2011，6，22： | 1 |
| 19 | Quantitative promoter methylatian analysis of multiple cancer-related genes in renal cell tumors显示文摘 | Costa VL Henrique R Ribeiro FR | 2007 | BMC Cancer2007，7，： | 1 |
| 20 | Clinical outcome of neonatal bacterial meningitis according to birthweight 显示文摘 | Krebs VL Costa GA | 2007 | Arq Neuropsiquiatr2007，65，4： | 1 |
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