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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Supplementing desflurane remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgegic requirements显示文摘 | Guignard B Coste C Costes H | 2002 | Anesth Analg2002，95，： | 1 |
| 3 | Piezol and Piezo2 are es- sential components of distinct mechanically activated cation channels显示文摘 | Coste B Mathur J Schmidt M | 2010 | Science2010，330，6000： | 1 |
| 4 | Cross sec- tional study of conventional cervical smear, monolayer cy-tology, and human papillomavirus DNA testing for cervical cancer screening显示文摘 | Coste J Cochand-Priollet B de Cremoux P | 2003 | BMJ2003，326，7392： | 1 |
| 5 | Effects of intermittent hy- puxic training on cycling performance in well-trained athletes显示文摘 | Roels B Bentley DJ Coste O | 2007 | Eur J Appl PhysioI2007，101，3： | 1 |
| 6 | The prognosis of heart failure in the general population:The rotterdam study显示文摘 | Cost B Hoes AW | 2001 | Eur Heart J2001，22，： | 1 |
| 7 | Tympanostomy tubesequelae in children with otitis media with effusion : a three - yearfollow - up study 显示文摘 | PEREIRA M B PEREIRA D R COST S S | 2005 | Braz J Otorhinolaryngol2005，71，4： | 1 |
| 8 | 1 Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | GUIGNARD B BOSSARD AE COSTE C eta | 2000 | Anesthesiology2000，93，2： | 1 |
| 9 | Both soluble and membrane-anchored forms of felid herpesvirus 1 glycoprotein G function as a broad-spectrum chemokinebinding protein显示文摘 | COSTES B RUIZ-ARGUELLO M B BRYANT N A | 2005 | J Gen Virol2005，86，12： | 1 |
| 10 | Nitrous oxide prevents movement during orotracheal intubation without affecting BIS value显示文摘 | Coste C Guignard B Menigaux C | 2000 | Anesth Analg2000，91，1： | 1 |
| 11 | The prognosis of heart failure in the generalk population:The Rotterdam Study显示文摘 | Mosterd A Cost B Hoes AW | 2001 | Eur Heart J2001，22，15： | 1 |
| 12 | Acute opioid tolerance :in- traoperativc remifentanil increases postoperative pain and morphine re- quirement显示文摘 | Guignard B Bossard AE Coste C | 2012 | Anesthesiology2012，939，2： | 1 |
| 13 | Mechanics of granular materials at low effective stresses 显示文摘 | Sture S Costes N C Batiste S N Lankton M R Alshibli K A Jeremic B Swanson R A Frank M | 1998 | Journal of Aerospace Engineering1998，11，2： | 1 |
| 14 | Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements显示文摘 | Guignard B Coste C Costes H | 2002 | Anesth Analg2002，95，1： | 1 |
| 15 | Acute opioid tolerance: in- traoperative remifentanil increases postoperative pain and morphine requirement 显示文摘 | Guignard B Bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 16 | TLR3 can directly trigger ap- optosis in human cancer cells 显示文摘 | Salaun B Coste I Rissoan M C | 2006 | J Immunol2006，176，8： | 1 |
| 17 | Training invariant support vector machines显示文摘 | De Coste D Sch(o)lkopf B | 2001 | Machine Learning2001，46，13： | 1 |
| 18 | Aute opioid tolerance:intraoperative remifentanil increases postoperative pain and morphine requirement显示文摘 | Guignard B bossard AE Coste C | 2000 | Anesthesiology2000，93，2： | 1 |
| 19 | Flagellin stimulation of intestinal epithelial cellstriggers CCL20-mediated migration of dendritic cells 显示文摘 | SIERRO F DUBOIS B COSTE A | 2001 | PNAS USA2001，98，13： | 1 |
| 20 | Assessing foliar chlorophyll contents with the SPAD -502 chlorophyll meter: a calibration test with thirteen tree species of tropical rainforest in French Guiana显示文摘 | Coste S Baraloto C Leroy C Marcon Renaud A Richardson A D Roggy J C Schimann H Uddling J H6rault B | 2010 | Annals of Forest Science2010，67，6： | 1 |
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