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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Left ventricular aneurysm:a new surgical approach显示文摘 | Saab M Coste P | 1989 | Thorac Cardiovasc Surg1989，37，1： | 1 |
| 3 | Piezol and Piezo2 are es- sential components of distinct mechanically activated cation channels显示文摘 | Coste B Mathur J Schmidt M | 2010 | Science2010，330，6000： | 1 |
| 4 | Seasonal succession of dia- toms and Chlorophyceae in the drainage network of the Seine River:observations and modeling显示文摘 | Gamier J Billen G Coste M | | 0，，： | 1 |
| 5 | Nasal immunization with Salmonella typhimurium producing Rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring显示文摘 | Cohen J Reinhardt M | 2001 | Vaccine2001，19，30： | 1 |
| 6 | Unprecedented ferromagnetic interaction in homobinnuclear erbium and gadolinium complexes: structural and magnetic studies 显示文摘 | COSTES J P CLEMENTE-JUAN J M DAHAN F | 2002 | Angewandte Chemie2002，41，2： | 1 |
| 7 | Overview of Fire Retardant Meehanisms显示文摘 | Camino G Cost L Luda Di Cortemiglia M P | 1991 | Polymer Degradation and Stability1991，33，2： | 1 |
| 8 | Herbicide effects on freshwater benthic diatoms:Induction of nucleus alterations and silica cell wall abnormalities显示文摘 | DEB T SILVESTRE J COSTE M | 2008 | Aquatic toxicology2008，88，： | 1 |
| 9 | Importance of in-hospital initiation of therapies and therapeutic inertia in secondary stroke prevention: IMplementation of Prevention After a Cerebrovascular evenT (IMPACT) Study 显示文摘 | Touze E Coste J Voicu M | 2008 | Stroke2008，39，6： | 1 |
| 10 | Tympanostomy tubesequelae in children with otitis media with effusion : a three - yearfollow - up study 显示文摘 | PEREIRA M B PEREIRA D R COST S S | 2005 | Braz J Otorhinolaryngol2005，71，4： | 1 |
| 11 | 查看详情显示文摘 | Naulin C Costes M Moudden Z Ghanem N Dorthe G | | 0，，： | 1 |
| 12 | Both soluble and membrane-anchored forms of felid herpesvirus 1 glycoprotein G function as a broad-spectrum chemokinebinding protein显示文摘 | COSTES B RUIZ-ARGUELLO M B BRYANT N A | 2005 | J Gen Virol2005，86，12： | 1 |
| 13 | Pharmacological charac-terization of muscarinic receptors implicated in rabbit detru-sor muscle contraction and activation of inositol phospholip-ids hydrolysis in rabbit detrusor and parotid gland显示文摘 | Barros M Coste A Eon MT | 1999 | Fun-dam Clin Pharmacol1999，13，5： | 1 |
| 14 | Stability of carmustine in polyvinyl chloride bags and polyethylene-lined trilayer plastic containers显示文摘 | Favier M De Cazanove F Coste A | 2001 | Am J Health Syst Pharm2001，58，3： | 1 |
| 15 | Chemotherapy of advanced small- bowel adenocarcinoma:a multicenter AGEO study显示文摘 | Zaanan A Costes L Gauthier M | 2010 | Ann Oncol2010，21，9： | 1 |
| 16 | TAC1,transcriptional activator of CDR genes,is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2显示文摘 | Coste A T Karababa M Ischer F | 2004 | Eukaryot Cell2004，3，6： | 1 |
| 17 | Mechanics of granular materials at low effective stresses 显示文摘 | Sture S Costes N C Batiste S N Lankton M R Alshibli K A Jeremic B Swanson R A Frank M | 1998 | Journal of Aerospace Engineering1998，11，2： | 1 |
| 18 | Interleukin-1 in multiple myeloma:producer cells and their role in the control of IL-6 production显示文摘 | Costes V Portier M Lu ZY | 1998 | Br J Haematol1998，103，4： | 1 |
| 19 | Robotic whole body stereotactic radiosurgery: clinical advantages of the CyberKnife integrated system显示文摘 | Coste M E Olender D Kilby W | 2005 | Int J Robotics and Computer Assisted Surg2005，1，2： | 1 |
| 20 | TLR3 can directly trigger ap- optosis in human cancer cells 显示文摘 | Salaun B Coste I Rissoan M C | 2006 | J Immunol2006，176，8： | 1 |
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