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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Neurological manifestations and neuroradiological presentation of Erdheim?Chester disease: report of 6 cases and systematic review of the literature显示文摘 | Lachenal F Cotton F Desmurs-Clavel H | 2006 | J Neurol2006，253，10： | 1 |
| 3 | Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical followup显示文摘 | Cotton h Dewatre F Cortet B | 1996 | Radiology1996，2000，： | 1 |
| 4 | Generation of re- combinant parapoxviruses: Non-essential genes suitable for insertion and expression of foreign genes显示文摘 | Rziha H Henkel M Cottone R | 2000 | J Bio- technol2000，83，12： | 1 |
| 5 | Piezoelectric buckled beams for random vibration energy harvesting 显示文摘 | Cottone F Gammaitoni L Vocca H | 2012 | Smart Materials and Structures2012，21，03： | 1 |
| 6 | Parapoxvirus- es:Potential alternative vectors for directing the im- mune response in permissive and non-permissivehosts显示文摘 | Rziha H J Henkel M Cottone R | 1999 | J Biotechno11999，73，23： | 1 |
| 7 | Epiglottoplasty forthe treat-ment of laryngomalacia 显示文摘 | Zalzal G H Anon J B Cotton R T | 1987 | Ann Otol RhinolLaryngol1987，96，11： | 1 |
| 8 | Neonatal meningitis:What is the correlation among CSF cultures, blood cultures and CSF parameters 显示文摘 | Garges H P Moody A Cotton M | 2006 | Pediatrics2006，117，4： | 1 |
| 9 | The Hydrodynamic Effects of Single Phase Flow on Flow Accelerated Corrosion in a 90-degree Elbow显示文摘 | Gammal M E Mazhar H Cotton J S | 2010 | Nu- clear Engineering and Design2010，，240： | 1 |
| 10 | The effect of propofol on the canine sphincter of Oddi显示文摘 | Baron T H Dalton C B Cotton P B | 1994 | HPB Surg1994，7，29： | 1 |
| 11 | Asymmetric synthesis of esomeprazole显示文摘 | Cotton H Elebring T Larsson M | 2000 | Tetrahedron: Asymmetry2000，11，18： | 1 |
| 12 | Cloning of tmpomyosins from lobster (Homarus americanus) striated muscles, fast and slow isoforms may be generated from the same transcript 显示文摘 | Mykles DL Cotton JL Taniguchi H | 1998 | J Muscle Res Cell Motil1998，19，2： | 1 |
| 13 | Clinical presentation and outcome of tuberculosis in human immunodeficiency virus infected children on anti-retroviral therapy 显示文摘 | Waiters E Cotton M F Rabie H | 2008 | BMC Pediatr2008，8，： | 1 |
| 14 | Vitellogenesis and its control in Malacostracan Crustacea显示文摘 | Charniaux - Cotton H | 1985 | Amer Zool1985，25，： | 1 |
| 15 | A novel thick-film piezoelectric slip sensor for a prosthetic hand显示文摘 | Cotton D P J Chappell P H Cranny A | | 0，，05： | 1 |
| 16 | Reactivity of cytosine and thymine in single base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations显示文摘 | Cotton R H Rodrigues N R Campbell R D | 1988 | Proc Natl Acad Sci USA1988，85，2： | 1 |
| 17 | Alternative bearing mate- rials for intervertebral disc arthroplasty 显示文摘 | Grupp TM Meisel H J Cotton JA | 2010 | Biomaterials2010，31，3： | 1 |
| 18 | Modeling of thrust fronts above duc- tile and frictional detachments: Application to structures in the Salt Range and Potwar Plateau, Pakistan显示文摘 | Cotton J T Koyi H A | 2000 | Geological Society of America Bulletin2000，112，3： | 1 |
| 19 | Should we consider polluting hurricanes to reduce their intensity显示文摘 | COTTON W R ZHANG H N MCFARQUHAR G M | 2007 | Journal of Modification2007，39，： | 1 |
| 20 | Nonlinear energy harvesting 显示文摘 | Cottone F Vocca H Gammaitoni L | 2008 | Phys Rev Lett2008，102，08： | 1 |
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