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| 1 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 2 | Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia 显示文摘 | Regine WF Courtney C | 2000 | J Neurosurg2000，93，3： | 1 |
| 3 | Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia 显示文摘 | Regine WF Courtney C | 2000 | J Neurosurg2000，93，： | 1 |
| 4 | CO2-in- duced ocean acidification impairs calcification in the tropical urchin Echinometra viridis显示文摘 | COURTNEY T WESTFIELD I RIES J B | 2013 | Journal of Ex- perimental Marine Biology and Ecology2013，440，1： | 1 |
| 5 | Synthesis of Cu-NbC nanocomposites bymechanical alloying显示文摘 | Murphy B R Courtney T H | 1994 | NanoStructured Materials1994，4，： | 1 |
| 6 | The dimensionality ofthe self-esteem: a hierarchical facet model for re-vised meas- urement scales显示文摘 | Fleming J S Courtney B E | 1984 | Journal of Personality and Social Psy- chology1984，46，： | 1 |
| 7 | Perceived Causes and Solutions of the Translation Problem in Management Research显示文摘 | SHAPIRO D L KIRKMAN B L COURTNEY H G | 2007 | Academy of Management Journal2007，50，2： | 1 |
| 8 | Reaction Rates During Mechanical Alloying 显示文摘 | AIKIN B J M COURTNEY T H etal | 1991 | Materials Science and Engineering1991，，147： | 1 |
| 9 | Polyethylene/boron composites for radiation shielding applications显示文摘 | Courtney H Eric B Nolan H | 2008 | Space Technology and Appli-cations International Forum2008，969，1： | 1 |
| 10 | Polyethylene/boron nitride composites for space radiation shielding显示文摘 | Courtney H Sean W Craig B | 2008 | Journal of Applied PolymerScience2008，109，4： | 1 |
| 11 | A phase1study of everoiimus and docetaxel in patients with cas-tration-resistant prostate cancer 显示文摘 | Courtney K D Manola J B Elfiky A A | 2015 | Clin GenitourinCancer2015，13，2： | 1 |
| 12 | Inhibition of nitrosomonas europea by monoterpenes from coastal redwood (sequoiasempervirens) in whole cell studies显示文摘 | Ward B B Courtney K J Langenheim J H | 1997 | Journal of Chemical Ecology1997，23，11： | 1 |
| 13 | Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia 显示文摘 | Regine WF Courtney C | 2000 | J Neurosurg2000，93，3： | 1 |
| 14 | The use of thermal analysis in the determination of the crystalline fraction of slag films 显示文摘 | K C Mills L Courtney A B Fox B Harris | 2002 | Thermochimica Acta2002，391，12： | 1 |
| 15 | The kinetics of composite particle formation during mechanical alloying 显示文摘 | AIKIN B J M COURTNEY T H | 1993 | Metallurgical Transactions A1993，24，3： | 1 |
| 16 | Implicit prejudice toward injec- ting drug users predicts intentions to change jobs among drug and alcohol nurses显示文摘 | William H Loren B Courtney H | 2008 | PSS2008，19，1： | 1 |
| 17 | The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels显示文摘 | Griffin Courtney T Curtis Carol D Davis Reema B | 2011 | Proc Natl Acad Sci USA2011，108，6： | 1 |
| 18 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
| 19 | The kinetic of composite particle formation during mechanical alloying 显示文摘 | Aikin B J M Courtney T H | 1993 | Metall Trans1993，24，3： | 1 |
| 20 | 2015, Microbial community structure mediates response of soil C decomposition to litter addition and warming 显示文摘 | COURTNEY A C Alexandre B M Evelyn S K | 2015 | Soil Biology and Biochemistry2015，80，： | 1 |
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