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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 4 | Introduction to a system for distributed databases (SDD-1)显示文摘 | Rothnie Jr J B Bernstein P A Fox S | 1980 | ACM Transactions on Database Systems (TODS)1980，5，1： | 1 |
| 5 | Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events(TRA 2°P)-TIMI 50 trial 显示文摘 | MORROW D A SCIRICA B M FOX K A | 2009 | Am Heart J2009，158，3： | 1 |
| 6 | Performance and Properties of Mould Fluxes显示文摘 | Mills K C Fox A B Li Z | 2005 | Ironmaking Steelmaking2005，32，1： | 1 |
| 7 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 8 | The interactive workspaces project: Experiences with ubiquitous computing rooms 显示文摘 | JOHANSON B FOX A WINOGRAD T | 2002 | IEEE Pervasive Computing2002，1，2： | 1 |
| 9 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 10 | On the modeling of actuator dynamics and the computation of prescribed trajectory显示文摘 | FOX B JENNINGS L S ZOMAYA A Y | 2002 | Computers and Structures2002，80，7： | 1 |
| 11 | Activity and safety of crizotinib in patients with ALK -positive non-small-cell lung cancer: updated results from a phase 1 study显示文摘 | D Ross Camidge Yung-Jue Bang Eunice L Kwak A John Iafrate Marileila Varella-Garcia Stephen B Fox Gregory J Riely Benjamin Solomon Sai-Hong I Ou Dong-Wan Kim Ravi Salgia Panagiotis Fidias Jeffrey A Engelman Leena Gandhi Pasi A J?nne Daniel B Costa Geoffrey | 2012 | Lancet Oncology2012，，10： | 1 |
| 12 | Trends in Biotechnology,显示文摘 | Fox D B Moody T S | 2001 | 19:292001，19，： | 1 |
| 13 | On the modeling of actuator dynamics and the computation of prescribed trajectories显示文摘 | FOX B JENNINGS L S ZOMAYA A Y | | 0，，7： | 1 |
| 14 | The role of mould fluxes in continuous casting-so simple yet so complex 显示文摘 | Mills K C Fox A B | 2003 | ISIJ International2003，43，： | 1 |
| 15 | Abyssal anti-dunes显示文摘 | Fox P J Heezen B C Harian A M | 1968 | Nature1968，220，： | 1 |
| 16 | Predators suppress Aphis glycines Matsumura population growth in soybean 显示文摘 | Fox T B Landis D A Cardoso F F | 2004 | Environ Entomo12004，33，： | 1 |
| 17 | The afterglow of GRB 050709 and the nature of the short-hard γ-ray bursts显示文摘 | FOX D B FRAIL D A PRICE P A | 2005 | Nature2005，437，： | 1 |
| 18 | Use of Thermal Analysis in Determination Crystalline Fraction of Slag Film 显示文摘 | Mills K C Kertney L Fox A B | 2002 | Thermochimica Acta2002，391，2： | 1 |
| 19 | Glucosamine hydrochloride for the treat- ment of osteoarthritis symptoms 显示文摘 | Fox B A Stephens M M | 2007 | Clin Interv Aging2007，2，4： | 1 |
| 20 | Dissecting intramural haematoma of the oesophagus显示文摘 | Modi P Edwards A Fox B | 2005 | Eur J Cardiothorac Surg2005，27，1： | 1 |
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