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| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | Toluene degradation by a water/silicone oil mixture for the design of two phase partitioning bioreactors显示文摘Toluene degradation performances were studied in a 10 L Two-Phase Partitioning Bioreactor(TPPB).The liquid phase consisted of a mixture of water and PDMS 50(Poly Di Methyl Siloxane,i.e.silicone oil,viscosity of 46 m Pa·s) in the volume ratio of 75%/25%.Two series of experiments were carried out:in the first,the reactor was sequentially supplied with toluene whereas in the second,toluene was continuously supplied.Activated sludge from the wastewater treatment plant of Beaurade(Rennes,France) was used at an initial concentration of 0.5 dry mass g·(mixture L)^(-1).The elimination capacity(EC) was investigated as well as the change in biomass concentration over time.Toluene biodegradation was very ef ficient(removal ef ficiency,RE=100%) for toluene flows ranging from 0.2 to 1.2 ml·h^(-1),corresponding to elimination capacities of up to 104 g·m^(-3)·h^(-1).For a toluene flow of 1.2 ml·h^(-1),the biomass concentration measured at the end of the experiment was 4.7 dry mass g·(mixture L)^(-1).The oxygen concentration in the liquid phase was clearly not a limiting factor in these operating conditions.Based on these results,an extrapolation leading to the design of a large-scale pilot TPPB can now be considered to study toluene degradation performances in industrial conditions. | Maxime Guillerm Annabelle Couvert Abdeltif Amrane Edith Norrant Audrey Breton éric Dumont | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 2 |
| 3 | On calculating sterility in thermal preservation methods:application of the Weibull frequency distribution model显示文摘 | Marfart P Couvert O Gaillard S | 2002 | International Journal of Food Microbiology2002，72，1： | 1 |
| 4 | Validation of a stochastic modelling approach for Listeria monocytogenes growth in refrigerated foods显示文摘 | Couvert O Pinon A Bergis H | 2010 | International Journal of Food Microbiology2010，144，2： | 1 |
| 5 | Ozonation effect on natural organic matter adsorption and biodegradation – Application to a membrane bioreactor containing activated carbon for drinking water production显示文摘 | Ronan Treguer Romuald Tatin Annabelle Couvert Dominique Wolbert Annie Tazi-Pain | 2009 | Water Research2009，，3： | 1 |
| 6 | Ozonation effect on natural organic matter adsorption and biodegradation-application to a membrane bioreaetor containing activated carbon for drinking water production显示文摘 | Treguer R Tatin R Couvert A | 2010 | Water Research2010，44，： | 1 |
| 7 | Biodegradation of toluene in a two-phase partitioning bioreactor-impact of activated sludge acclimation显示文摘 | Bechohra I Couvert A Amrane A | 2014 | Environmental Technology2014，35，6： | 1 |
| 8 | In vitro follicular growth affects oocyte imprinting establishment in mice 显示文摘 | Kerjean A Couvert P Heams T | 2003 | Eur J Hum Genet2003，11，7： | 1 |
| 9 | Treatment of odorous sulphur compounds by chemical scrubbing with hydrogen peroxide-Application to a laboratory plant显示文摘 | Couvert A | 2006 | Chemical Engineering Science2006，，61： | 1 |
| 10 | Removal of hydrophobic volatile organic compounds in an integrated process coupling absorption and biodegradation-selection of an organic liquid phase显示文摘 | Darracq Q Couvert A Couriol C | 2012 | Water Air & Soil Pollution2012，223，8： | 1 |
| 11 | Survival curves of heated bacterial spores, effect of environmental factors on Weibull parameters显示文摘 | COUVERT O GAILLARD S SAVY N | 2005 | International Journal of Food Microbiology2005，101，1： | 1 |
| 12 | Optimization of the Volume Fraction of the NAPL, Silicone Oil, and Biodegrada- tion Kinetics of Toluene and DMDS in a TPPB 显示文摘 | Darracq G Couvert A Couriol C | 2012 | lnt Biodete- riorBiodegrad2012，71，： | 1 |
| 13 | On calculating sterility in thermal preservation methods: application of the Weibull frequency distribution model 显示文摘 | Mafart P Couvert O Gaillard S | 2002 | International Journal of Food Microbiology2002，72，2： | 1 |
| 14 | Hydrophobic VOC absorption in two-phase partitioning bioreactors; influence of silicone oil volume fraction on absorber diameter显示文摘 | Eric Dumont Guillaume Darracq Annabelle Couvert Catherine Couriol etc | 2012 | Chemical En-gineeringScience2012，，71： | 1 |
| 15 | In vitro follicular growth affects oecyte imprinting estabhshment in mice显示文摘 | Couvert P Heams T | 2003 | Eur J Hum Genet2003，11，7： | 1 |
| 16 | Prediction of liquid velocity and gas hold-up in rectangular air-lift reactors of different scales 显示文摘 | Couvert A Bastoul D Roustan M | 2001 | Chemical Engineering and Processing2001，40，2： | 1 |
| 17 | Plasma bilirubin and gamma-glutamyltransferase activity are inversely related in dyslipidemicpatients with metabolic syndrome : relevance to oxidative stress显示文摘 | Giral P Ratziu V Couvert P | 2010 | Atheroslerosis2010，210，2： | 1 |
| 18 | Plasma bilirubin and gamma-glutamyltransferase activity are inversely related in dyslipidemic patients with meta- bolic syndrome: Relevance to oxidative stress 显示文摘 | GIRAL P RATZIU V COUVERT P | 2010 | Atherosclerosis2010，210，： | 1 |
| 19 | On calculating sterility in thermal preservation methods: application of the Weibull frequency distribution model显示文摘 | MAFART P COUVERT O GAILLARD S | 2002 | International Journal of Food Microbiology2002，72，： | 1 |
| 20 | In vitro follicular growth affects oocyte imprinting establishment in mice 显示文摘 | Kerjean A Couvert P Heams T | 2003 | Eur J Hum Genet2003，11，7： | 1 |
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