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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Retinal detachment due to ocular contusion显示文摘 | Cox MS Schepens CL Freeman HM | 1966 | Arch Ophthalmol1966，76，11： | 1 |
| 3 | A quantitalive index derived from ^99mTe - perteehnetate seintigraphy to assist in the diagno- sis of primary Sjogren g syndrome显示文摘 | Markusse HM Pillay M Cox PH | 1992 | Nuklearmedizine1992，31，1： | 1 |
| 4 | Growth and ion uptake by wheat supplied nitrogen as nitrate,or ammonium,or both显示文摘 | Cox WJ Reisenau HM | | 0，，： | 1 |
| 5 | Effect of ectop ie expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice显示文摘 | Marchbank T Cox HM Goodlad RA | 2001 | J Biol (7hem2001，276，24： | 1 |
| 6 | Immunoprecipitation and characterization of a binding protein specific for the peptide, intestinal trefoil factor 显示文摘 | Chinery R Cox HM | 1995 | Peptides1995，16，4： | 1 |
| 7 | Endogenous PYY and GLP-1 mediate lglutamine responses in intestinal mucosa显示文摘 | Joshi S Tough IR Cox HM | 2013 | Br J Pharmacol2013，170，5： | 1 |
| 8 | Effect of ectopic ex-pression of rat trefoil factor family 3(in-testinal trefoil factor)in the jejunum of transgenic mice显示文摘 | MARCHBANK T COX HM GOOD-LAD RA | | 0，，26： | 1 |
| 9 | A quantitative index derived from 99m Te-- pertechnetate scintigraphy to assist in the diagno sis of primary Sjogron's syndrome显示文摘 | Markusse HM Pillay M Cox PH | 1992 | Nuklearmedizine1992，31，： | 1 |
| 10 | Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice 显示文摘 | Marchbank T Cox HM Goodlad RA | 2001 | J Biol Chem2001，276，24： | 1 |
| 11 | Identification of a highly polymorphic marker within intron 7 of the ALAS2 gene and suggestion of at least two loci for X-linked sideroblastic anemia显示文摘 | Cox TC Kozman HM and Raskind WH | 1992 | Hum Mol Genet1992，1，8： | 1 |
| 12 | Progressive facial hemiatrophy:MRI appearances显示文摘 | Taylor HM Robinson R Cox T | 1997 | Dev Med Child Neurol1997，39，7： | 1 |
| 13 | Immunoprecipitation and characterization of a binding protein specific for the peptide,intestinal trefoil factor显示文摘 | CHINERY R COX HM | 1995 | Peptides1995，16，4： | 1 |
| 14 | The effect of Neuropeptide Y and it's fragment upon basal and electrically stimulated ion secretiomnin rat jejunum mocosa显示文摘 | Cox HM Cuthbert AW | 1990 | BrJ Pharmaclo1990，101，： | 1 |
| 15 | Haplotype analysis of the HSD17BI gene and risk of breast cancer: a comprehensive approach to multicentcr analyses of prospective cohort studies 显示文摘 | Feigelson HS Cox DG Cann HM | 2006 | Cancer Res2006，66，4： | 1 |
| 16 | Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia显示文摘 | Cox CV Martin HM Kearns PR | 2007 | Blood2007，109，2： | 1 |
| 17 | Effect of LH injections on testicular steroidogenesis, cholesterol side-chain cleavage P450mRNA content and Leydig cell morphology in hypogonadal mice显示文摘 | Scott IS Charlton HM Cox BS | 1990 | J Endocrinol1990，125，1： | 1 |
| 18 | Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor显示文摘 | Chinery R Cox HM | 1995 | Br J Pharmacol1995，115，1： | 1 |
| 19 | Photorefractive keratectomy in children显示文摘 | Astle WF Huang PT Ells AL Cox RG Deschenes MC Vibert HM | 2002 | J Cataract Re- fract Surg2002，28，6： | 1 |
| 20 | Peptide YY is critical for acylethanolamine receptor Gprllg-induced activation of gastrointestinal mucosal responses 显示文摘 | Cox HM Tough IR Woolston AM | 2010 | Cell Metab2010，11，： | 1 |
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