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| 1 | ATP-dependent chromatin remodeling: genetics, genomics and mechanisms显示文摘用 ATP 水解作用的精力调整染色质结构的 Macromolecular 集会在开发,癌症,和干细胞生物学有关键角色。这个家庭的 ATPases 被 27 人的基因编码并且通常与稳定的几另外的蛋白质被联系,非可交换的子单元。这些建筑群使用的一基本机制被认为是 nucleosomes 的运动或交换调整抄写。然而,最近的基因研究显示染色质 remodelers 可以也涉及在许多细胞的过程期间调整染色质结构的另外的方面。SWI/SNF 家庭特别地看起来在子单元作文和与多细胞体和连接 histones 的外观的进化来临重合的机制经历了一个实质的变化。哺乳动物的 BAF 子单元的这更大的差异的微分用法为特定的房间命运的发展是必要的,包括到到承诺的神经原的 multipotency 的从 pluripotency 的前进。最近的人的基因屏幕表明了 BRG1, ARID1A, BAF155,和 hSNF5 经常在肿瘤被变异,显示 BAF 建筑群也起在癌症的开始或前进的一个关键作用。在开发和癌症为 BAF 和另外的染色质 remodelers 位于基因要求下面的机械学的库是相对未经勘探的并且将是这评论的一个焦点。 | Diana C Hargreaves Gerald R Crabtree | 2011 | Cell Research2011，21，3： | 51 |
| 2 | 幽门螺杆菌cagⅡ对胃上皮细胞IL-8基因转录的影响及机制显示文摘目的 探讨HpcagⅡ对胃上皮细胞IL 8基因转录的影响及信号传导机制。 方法 构建cagⅡ基因位点缺失Hp突变株及带有IL 8报告基因的人胃癌细胞系L5F11,用液体闪烁计数仪测定荧光素酶 (IL 8转录 )活性 ,用ELISA法测定IL 8蛋白浓度。结果 所有Hp突变株诱导荧光素酶活性与IL 8蛋白浓度较亲代菌株 2 6 6 95均降低 [(0 .13± 0 .0 1)× 10 6cpm比 (0 .5 9± 0 .0 5 )× 10 6cpm (P <0 .0 1) ;(0 .73± 0 .13)ng/ml比 (2 .2 2± 0 .6 5 )ng/ml,(P <0 .0 5 ) ]。PTK抑制剂herbimycinA不仅抑制Hp诱导的荧光素酶活性 [(0 .71± 0 .18)× 10 6cpm比 (1.5 1±0 .2 3)× 10 6cpm ,(P <0 .0 5 ) ],而且抑制IL 8蛋白表达 [(0 .83± 0 .41)ng/ml比 (3.2 2± 0 .5 9)ng/ml,(P <0 .0 5 ) ],但herbimycinA对TNFα诱导的荧光素酶活性及IL 8蛋白表达均无影响 (P均 >0 .0 5 ) ;PKA抑制剂H7抑制TNFα诱导的荧光素酶活性 [(0 .74± 0 .16 )× 10 6cpm比 (2 .6 2± 0 .2 6 )× 10 6cpm ,(P <0 .0 0 1) ]及IL 8蛋白表达 [(1.45±0 .38)ng/ml比 (4 .12± 0 .43)ng/ml,(P <0 .0 1) ],而对Hp诱导的荧光素酶活性无影响 (P >0 .0 5 )。 结论 HpcagⅡ中的多个基因能够调节胃上皮细胞IL 8基因转录 。 | 李淑德 许国铭 李兆申 Crabtree JE Neelam B | 2000 | 中华消化杂志2000，20，4： | 7 |
| 3 | Accumulation of Somatic Mutations in TP53 in Gastric Epithelium with Helicobacter pylori infection显示文摘 | Takahiro Shimizu Hiroyuki Marusawa Yuko Matsumoto Tadashi Inuzuka Atsuyuki Ikeda Yosuke Fujii Sachiko Minamiguchi Shin’ichi Miyamoto Tadayuki Kou Yoshiharu Sakai Jean E. Crabtree Tsutomu Chiba | 2014 | Gastroenterology2014，，： | 2 |
| 4 | Investigation of blood pulse PPG signal regulation on toe effect of body posture and lower limb height显示文摘Objective: To study the regulation of blood pulse volume via photoplethysmography (PPG) signal detected from toe, while the lower limb is passively raised in different height positions. Methods: Use a modified non-invasive PPG technique to detect the blood pulse signal on toe with infrared (IR) photo sensor. A protocol consisting of two postures, i.e., supine and 45° reclining, was designed to conduct laboratory trial in this study. During the period of performing the protocol of these postures, the lower limb was passively raised from the heights of 10 cm to 60 cm randomly and individually with sponge blocks underneath the foot. Results: In the supine posture, the higher the foot was passively raised, the more the blood PPG signal decreased. In the 45° reclining posture, the blood PPG signal increased at the beginning and then decreased in the foot height position from 10 cm to 60 cm. In both postures the normalized AC signal changes significantly while the normalized DC signal changes little. Conclusion: The toe PPG signals can obviously indicate the regulated blood volume change with the designated postural procedures due to the heart level position. | XIN Shang-zhi HU Sijung CRABTREE Vincent P. ZHENG Jia AZORIN-PERIS Vincent ECHIADIS Angelos SMITH Peter R. | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，6： | 2 |
| 5 | P recision L ivestock F arming: A n international review of scientific and commercial aspects显示文摘Precision Livestock Farming(PLF)is potentially one of the most powerful developments amongst a number of interesting new and upcoming technologies that have the potential to revolutionise the livestock farming industries.If properly implemented,PLF or Smart Farming could(1)improve or at least objectively document animal welfare on farms;(2)reduce greenhouse gas(GHG)emission and improve environmental performance of farms;(3)facilitate product segmentation and better marketing of livestock products;(4)reduce illegal trading of livestock products;and(5)improve the economic stability of rural areas.However,there are only a few examples of successful commercialisation of PLF technologies introduced by a small number of commercial companies which are actively involved in the PLF commercialisation process.To ensure that the potential of PLF is taken to the industry,it is recommended to:(1)establish a new service industry;(2)verify,demonstrate and publicise the benefits of PLF;(3)better coordinate the efforts of different industry and academic organisations interested in the development and implementation of PLF technologies on farms;and(4)encourage the commercial sectors to assist with professionally managed product development. | T M Banhazi H Lehr J L Black H Crabtree P Schofield M Tscharke D Berckmans | 2012 | International Journal of Agricultural and Biological Engineering2012，5，3： | 2 |
| 6 | Immunology of Helicobacter pylori : Insights Into the Failure of the Immune Response and Perspectives on Vaccine Studies显示文摘 | Keith T. Wilson Jean E. Crabtree | 2007 | Gastroenterology2007，，1： | 2 |
| 7 | The Impact of Auditor Tenure on Initial Bond Ratings 显示文摘 | Aaron D Crabtree Duane M Brandon John J Maher | 2006 | Advances in Accounting2006，22，6： | 1 |
| 8 | Selective performance of prophylactc omentopexy during laparoscopic implantation of peritoneal dialysis catheters显示文摘 | Crabtree JH Fishman A | 2003 | Surg Laparosc Endosc Percutan Tech2003，13，3： | 1 |
| 9 | Genetic signals and specific outcome: signaling through Ca2+,calcineurin,and NF-AT显示文摘 | Crabtree G R | 1999 | Cell1999，96，： | 1 |
| 10 | A laparoscopic method for optimal peritoneal dialysis access 显示文摘 | Crabtree JH Fishman A | 2005 | Am Surg2005，71，2： | 1 |
| 11 | Sediment origins, deposition and build-up in combined sewer systems显示文摘 | ASHLEY R M CRABTREE R W | 1992 | Water Science & Technology1992，25，8： | 1 |
| 12 | Social enterprises and non-market capitals: a path to degrowth? 显示文摘 | JOHANISOVA N CRABTREE T FRANKOVA E | 2013 | Journal of Cleaner Production2013，，38： | 1 |
| 13 | C-reactive protein ,obstructive sleep apnea and cognitive dysfunction in school-aged childen 显示文摘 | GOZAL D CRABTREE VM CAPDEVILA OS | 2007 | Am Respir Crit Care Med2007，176，2： | 1 |
| 14 | Neurocirculatory consequences of intermittent asphyxia in humans显示文摘 | Xie A Skatrud JB Crabtree DC | 2000 | J Appl Physio12000，89，4： | 1 |
| 15 | Recouphng the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recy- cling显示文摘 | Alkaitis M S Crabtree M J | 2012 | Curr Heart Fa//Rep2012，，： | 1 |
| 16 | Effective use of laparoscopiy for long-term peritoneal dialysis access显示文摘 | CRABTREE JH BURCHETFE RJ | 2009 | Am J Surg2009，198，1： | 1 |
| 17 | Isolation of arbovi- ruses from mosquitoes collected in northern Vietnam 显示文摘 | Bryant J E Crabtree M B Nam V S | 2005 | Am J Trop Med Hyg2005，73，2： | 1 |
| 18 | Lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS显示文摘 | Miwa J M Ibanez-Tallon I Crabtree G W | 1999 | Neu- ron1999，23，1： | 1 |
| 19 | Habitat use of red foxes in Yellowstone National Park based on snow tracking and telemetry显示文摘 | VAN ETTEN K W WILSON K R CRABTREE R L | 2007 | Journal of Mammalogy2007，88，6： | 1 |
| 20 | Transforming physician practices to patient - centered medical homes: Lessons from the Na- tional Demonstration Project 显示文摘 | Nutting PA Crabtree BF Miller WL | 2011 | Health Aft ( Millwood )2011，30，： | 1 |
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