|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Six-year outcomes in neovascular age-related macular degeneration with ranibizumab显示文摘● AIM: To evaluate the outcomes of ≥6y ranibizumab therapy in neovascular age-related macular degeneration(AMD).● METHODS: HELIX was a retrospective, observational effeciveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab(0.5 mg) between November 1, 2007 and October 31, 2008, had ≥6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity(BCVA) and central retinal thickness(CRT).● RESULTS: The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female(62.3%). Most eyes(62.5%) were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 292±86 μm. On average, patients received 20.6±11.9 ranibizumab injections over the ≥6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter(-0.9±17.3 letters), with an average loss of-3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na?ve eyes. When considering a loss of <15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive(improvement or stabilization) outcome. Mean change in CRT from baseline to last observation for the sample was-26.9±148.4 μm with the greatest reduction observed in treatment-naive eyes.● CONCLUSION: This retrospective study of 69 neovascular AMD patients treated for ≥6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers. | Julie Jacob Heidi Brié Anita Leys Laurent Levecq Filip Mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 5 |
| 2 | Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats显示文摘 | VAN CRAEYVELD V SWENNEN K DORNEZ E | 2008 | The Journal of Nutrition2008，138，12： | 1 |
| 3 | Gene therapy for familial hypercholesterolemia显示文摘 | VAN CRAEYVELD E JACOBS F GORDTS SC | 2011 | Curr Pharm Des2011，17，24： | 1 |
| 4 | Lipid lowering and HDL rai- sing gene transfer increase endothelial progenitor cells, enhance myocardial vas- cularity, and improve diastolic function显示文摘 | Gordts SC van Craeyveld E Muthuramu I | 2012 | PLoS One2012，7，46： | 1 |
| 5 | Ex-tensive dry ball milling of wheat and rye bran leads to in situ production of arabinoxylan oligosaccharides through nanoscale fragmentation显示文摘 | van Craeyveld V Holopainen U Selinheimo E | | 0，，18： | 1 |
| 6 | Gene therapy for familial hypercholesterolemia显示文摘 | Van Craeyveld E Jacobs F Gordts SC | | 0，，24： | 1 |
| 7 | Structurally different wheat - derived arabinoxy- looligosaccharides have different prebiotic and fermenta- tion properties in rats 显示文摘 | Van - Craeyveld V Swennen K E Van - De - Wiele T | 2008 | Journal of Nutrition2008，138，12： | 1 |
| 8 | Regression and stabilization of advanced murine atherosclerotic lesions:a comparison of LDL lowering and HDL raising gene transfer strategies显示文摘 | Van Craeyveld E Gordts SC Nefyodova E | | 0，，： | 1 |
| 9 | Recombinant expression and characterization of XynD from Bacillus subtilis subsp, subtilis ATCC 6051: a GH 43 arabinoxylan arabinofuranohydrolase 显示文摘 | Bourgois T M Craeyveld V V Campenhout S V | 2007 | Applied Microbiology and Biotechnology2007，75，6： | 1 |
| 10 | Structurally different wheat-derived arabinoxylooligosaccharides have different prebiotic and fermentation properties in rats显示文摘 | VAN CRAEYVELD V SWENNEN K DORNEZ E | 2008 | The Journal of Nutrition2008，138，12： | 1 |
| 11 | Regres- sion and stabilization of advanced murine atherosclerotic lesions:a comparison of LDL lowering and HDL raising gene transfer strategies显示文摘 | van Craeyveld E Gordts SC Nefyodova E | 2011 | J Mol Med2011，89，6： | 1 |
| 12 | Lipid lowering and HDL raising gene transfer increase endothelial progenitor cells, enhance myocardial vascularity, and improve diastolic function显示文摘 | Gordts SC Van Craeyveld E Muthuramu I | | 0，，： | 1 |
| 13 | A critical reassessment of murine and rabbit models of atherosclerosis:focus on lesion progression and remodelling显示文摘 | Van Craeyveld E Gordts SC Singh N | | Acta Cardiologica0，，： | 1 |
| 14 | Lipid lowering and HDL raising gene transfer increase endothelial progenitor cells, enhance myocardial vascularity, and improve diastolic function 显示文摘 | Gordts SC Van Craeyveld E Muthuramu I | 2012 | PLoS One2012，7，46： | 1 |
| 15 | Circulating apoptotic endothe- lial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy显示文摘 | Singh N Van Craeyveld E Tjwa M | 2012 | J Am Coil Cardio12012，60，4： | 1 |
| 16 | Critical role of scavenger receptor-BI-expressing bone marrow-derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apoA-I transfer 显示文摘 | Feng Y van Eck M Van Craeyveld E | 2009 | Blood2009，113，3： | 1 |
| 17 | Extensive dry ball milling of wheat and rye bran leads to in situ production of arabinoxylan oligosaccharides through nanoscale frag mentation显示文摘 | Van Craeyveld V Holopainen U Selinheimo E | 2009 | Journal of Agricultural and Food Chemistry2009，57，18： | 1 |
| 18 | Regres- sion and stabilization of advanced murine atherosclerotic le- sions : a comparison of LDL lowering and HDL raising gene transfer strategies 显示文摘 | Van Craeyveld E Gordts SC Nefyodova E | 2011 | J Mol Med2011，89，6： | 1 |
| 19 | Human ApoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow-derived endothelial progenitor cells 显示文摘 | Feng Y Jacobs F Van Craeyveld E | 2008 | Arterioscler Thromb Vasc Biol2008，28，2： | 1 |
| 20 | In vitro fermentation of arabinoxylan oligosaccharides and low mo- lecular mass arabinoxylans with different structural properties from wheat ( Triticum aestivum L ) bran and psyllium ( Plantago ova- ta Forsk) seed husk显示文摘 | Annick Pollet Valerie Van Craeyveld Tom Van de Wiele | 2012 | J Agric Food Chem2012，60，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员