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| 1 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 2 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 3 | Effects of Ionic Strength, Temperature, and pH on Degradation of Selected Antibiotics显示文摘 | Loftin Keith A Adams Craig D Meyer Michael T Surampalli Rao | 2008 | Journal of Environmental Quality2008，，2： | 2 |
| 4 | A high- density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease 显示文摘 | Coon K D Myers A J Craig D W | 2007 | J Clin Psychiatry2007，68，4： | 1 |
| 5 | Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch显示文摘 | Andrew D Craig A | 2001 | Nat Neurosci2001，4，1： | 1 |
| 6 | Rheological and physical differences between foam and emulsion fracturing fluids显示文摘 | Blauer R E Phillips A M Craig D P | 1988 | SPE18214 MS1988，，： | 1 |
| 7 | Functional imaging of an illusion of pain显示文摘 | Craig A D Reiman E M Evans A | 1996 | Nature1996，384，： | 1 |
| 8 | Effects of sewage effluent and ethynyl oestradiol upon molecular markers of oestrogenic exposure, maturation and repro ductive success in the sand goby显示文摘 | CRAIG D R BROWN E CRAFT J A | 2003 | Aquatic Toxicology2003，，62： | 1 |
| 9 | Thermosensory activation of insular cortex显示文摘 | Craig A D Chen K Bandy D | 2000 | Nat Neurosci2000，3，2： | 1 |
| 10 | Automotive crashworthiness design using response surface-based variable screening and optimization 显示文摘 | Craig K J Stander N Dooge D A | 2005 | Engineering Computations2005，22，12： | 1 |
| 11 | The mitochondrial small heat - shock protein protects NADH: ubiquinone oxidoreductase of the electron transport chain during heat stress in plants显示文摘 | Craig A D Scott A H | 1998 | Biochemical1998，，430： | 1 |
| 12 | Image - guided radiotherapy :has it influenced patient outcomes 显示文摘 | Bujold A Craig T Jaffray D | 2012 | Semin Radiat Oncol2012，22，1： | 1 |
| 13 | Significance of the insula for the evolution of human awareness of feelings from the body显示文摘 | Craig A D | 2011 | Ann N Y Acad Sci2011，1225，： | 1 |
| 14 | Thermosensory activation of insular cortex显示文摘 | Craig A D Chen K Bandy D | 2000 | Nat Neurosci2000，3，2： | 1 |
| 15 | Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex显示文摘 | Han S Craig J A Putnam C D | 1999 | Nat Struct Biol1999，6，10： | 1 |
| 16 | NMDA receptor activation mediates copper homeostasis in hippocampal neurons显示文摘 | Schlief M L Craig A M Gitlin J D | 2005 | The Journal of neuroscience2005，25，1： | 1 |
| 17 | Uptake and transformation of soil-trinitrotoluene by cool-season grasses显示文摘 | DURINGER J M MORRIE CRAIG A SMITH D J | 2010 | Environmental science&technology2010，44，16： | 1 |
| 18 | A high- density whole-genome association study reveals that APOE is the major Susceptibility gene for sporadic late-onset Alzheimer's disease 显示文摘 | Coon K D Myers A J Craig D W | 2007 | J Clin Psychiatry2007，68，4： | 1 |
| 19 | Disinfection of swine wastewater using chlorine,ultraviolet light and ozone 显示文摘 | John J M Zhimin Q Craig D A | 2006 | Water Research2006，40，： | 1 |
| 20 | Micromechanical adhesion force measurements between tetrahydrofuran hydrate particles显示文摘 | Taylor Craig J Dieker Laura E Miller Kelly T Koh C A Sloan E D | | 0，，： | 1 |
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