5篇
您的检索式：作者名="Craig McIntosh"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Competition and microfinance显示文摘 | Craig McIntosh Bruce Wydick | 2005 | Journal of Development Economics2005，，2： | 1 |
| 2 | The Supply and Demand-Side Impacts of Credit Market Information显示文摘 | Alain de Janvry Craig McIntosh Elisabeth Sadoulet | 2009 | Journal of Development Economics2009，，： | 1 |
| 3 | Microfinance and Home Improvement:Using Retrospective Panel Data to Measure Program Effects on Fundamental Events显示文摘 | CRAIG MCINTOSH GONZALO VILLARAN BRUCE WYDICK | 2011 | World Development2011，39，6： | 1 |
| 4 | Neurodegenerative diseases:a hotbed for splicing defects and the potential therapies显示文摘Precursor messenger RNA(pre-mRNA)splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions(introns)and ligates coding regions(exons)into a continuous message(mature mRNA).This process is highly regulated and can be highly flexible through a process known as alternative splicing,which allows for several transcripts to arise from a single gene,thereby greatly increasing genetic plasticity and the diversity of proteome.Alternative splicing is particularly prevalent in neuronal cells,where the splicing patterns are continuously changing to maintain cellular homeostasis and promote neurogenesis,migration and synaptic function.The continuous changes in splicing patterns and a high demand on many cis-and trans-splicing factors contribute to the susceptibility of neuronal tissues to splicing defects.The resultant neurodegenerative diseases are a large group of disorders defined by a gradual loss of neurons and a progressive impairment in neuronal function.Several of the most common neurodegenerative diseases involve some form of splicing defect(s),such as Alzheimer’s disease,Parkinson’s disease and spinal muscular atrophy.Our growing understanding of RNA splicing has led to the explosion of research in the field of splice-switching antisense oligonucleotide therapeutics.Here we review our current understanding of the effects alternative splicing has on neuronal differentiation,neuronal migration,synaptic maturation and regulation,as well as the impact on neurodegenerative diseases.We will also review the current landscape of splice-switching antisense oligonucleotides as a therapeutic strategy for a number of common neurodegenerative disorders. | Dunhui Li Craig Stewart McIntosh Frank Louis Mastaglia Steve Donald Wilton May Thandar Aung-Htut | 2021 | Translational Neurodegeneration2021，10，2： | 0 |
| 5 | A crash to ice显示文摘Did you see American figure skater,Jeremy Abbott,crash to the ice during the short program at the Sochi 2014 Winter Olympics,rolling into the wall,clutching his side in pain.Ten seconds later,he got up and continued his skate—despite the pain,embarrassment and fear. | Craig Mcintosh | 2018 | 疯狂英语(新读写)2018，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员