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3篇 您的检索式:作者名="Creed M.Stary"
    题名 作者 年代 出处 被引量
1Serum prealbumin as an effective prognostic indicator for determining clinical status and prognosis in patients with hemorrhagic stroke显示文摘Serum prealbumin is a recognized marker of malnutrition,but its prognostic role in patients with hemorrhagic stroke remains unclear.In this study,we retrospectively reviewed the records of 105 patients with hemorrhagic stroke admitted to Renmin Hospital of Wuhan University,China,from January to December 2015.We collected demographic and radiological data,and recorded serum prealbumin levels at admission and on days 1,3,6,9,and 14–21.The existence of infections and gastrointestinal hemorrhage,and clinical condition at discharge were also recorded.Serum prealbumin levels during hospitalization were significantly lower in patients with infections compared with those without infections,and also significantly lower in patients with gastrointestinal hemorrhage compared with those without.Serum prealbumin levels at discharge were significantly higher in patients with good recovery than in those with poor recovery.We conclude that regular serum prealbumin measurements in patients with hemorrhagic stroke may be a useful indicator for determining clinical status and prognosis,which may therefore help to guide clinical decision-making.Shen-qi Zhang Bin Peng Creed M.Stary Zhi-hong Jian Xiao-xing Xiong Qian-xue Chen 2017Neural Regeneration Research2017,12,7:17
2Adult neurogenesis from reprogrammed astrocytes显示文摘The details of adult neurogenesis,including environmental triggers,region specificity,and species homology remain an area of intense investigation.Slowing or halting age-related cognitive dysfunction,or restoring neurons lost to disease or injury represent just a fraction of potential therapeutic applications.New neurons can derive from stem cells,pluripotent neural progenitor cells,or non-neuronal glial cells,such as astrocytes.Astrocytes must be epigenetically'reprogrammed'to become neurons,which can occur both naturally in vivo,and via artificial exogenous treatments.While neural progenitor cells are localized to a few neurogenic zones in the adult brain,astrocytes populate almost every brain structure.In this review,we will summarize recent research into neurogenesis that arises from conversion of post-mitotic astrocytes,detail the genetic and epigenetic pathways that regulate this process,and discuss the possible clinical relevance in supplementing stem-cell neurogenic therapies.Brian B.Griffiths Anvee Bhutani Creed M.Stary 2020Neural Regeneration Research2020,15,6:1
3Exploring and exploiting unique properties of the hippocampal dentate gyrus for post-stroke therapy:astrocytes link ischemic resistance with neurogenic potential显示文摘Acute cerebral ischemia can occur secondary to embolism,cardiac arrest,hemorrhage,traumatic brain injury,edema,vascular compression,or any physiologic condition resulting in low cardiac output state.Survivors of cerebral ischemic events frequently suffer from profound disability,accounting for>$70billion in 2010 for treatment of embolic stroke in the US alone.More strikingly,the cost to treat stroke in the US isCreed M.Stary 2016Neural Regeneration Research2016,11,11:0
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