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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Widespread deregulation of microRNA expression in human prostate cancer显示文摘 | Ozen M Creighton C J Ozdemir M Ittmann M | 2008 | Oncogene2008，27，12： | 1 |
| 3 | Plasma Resonance Enhancement of Raman Scattering by Pyridine Adsorbed on Silver or Gold Sol Particles of Size Comparable to the Excitation Wavelength显示文摘 | CREIGHTON J A BLATCHFORD C G ALBRECHT M G | 1979 | J Chem Soc1979，75，： | 1 |
| 4 | Widespread deregulation of microRNA expression in human prostate cancer显示文摘 | Ozen M Creighton C J Ozdemir M Ittmann M | 2008 | Oncogene2008，27，： | 1 |
| 5 | Intranasal flumazenil andnaloxone to reverse over-sedation in a child undergoing dentalrestorations显示文摘 | Heard C Creighton P Lerman J | 2009 | Paediatr Anaesth2009，19，8： | 1 |
| 6 | Mining gene expression databases for association rules显示文摘 | Creighton C Hanash S | 2003 | Bioinformaties2003，19，1： | 1 |
| 7 | Plasma resonance enhancement of Raman scattering by pyridine adsorbed on silver or gold sol particles of size comparable to the excitation wavelength显示文摘 | Creighton J A Blatchford C G Albrecht M G | 1979 | J Chem Soc Faraday Trans1979，75，： | 1 |
| 8 | Modeling the parasitic chemical reactions of AlGaN or- ganometallic vapor-phase epitaxy显示文摘 | Michael E Coltrin Randall Creighton J Christine C Mitc- hell | 2006 | J Cryst Growth2006，287，2： | 1 |
| 9 | A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer 显示文摘 | Nagaraja A K Creighton C J Yu Z | 2010 | Mol Endocrino12010，24，2： | 1 |
| 10 | Developm-ent of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts显示文摘 | CREIGHTON C J MASSARWEH S HUANG S | 2008 | Cancer Res2008，68，18： | 1 |
| 11 | Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma显示文摘 | GIBBONS D L LIN W CREIGHTON C J | 2009 | PLoS One2009，4，4： | 1 |
| 12 | Mining gene expression databases for association rules 显示文摘 | Creighton C Hanash S | 2003 | Bioinformatics2003，19，1： | 1 |
| 13 | Mining gene expression databases for association rules显示文摘 | Creighton C Hanash S | 2003 | Bioinformatics2003，19，1： | 1 |
| 14 | Proteomic and transcriptomic profiling reveals a link between the PISK pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer显示文摘 | Creighton C J Fu X Hennessy BT | 2010 | Breast Cancer Res2010，12，3： | 1 |
| 15 | Mining gene expression databases for association rules显示文摘 | Creighton C Hanash S | 2003 | Bioinformatics2003，19，1： | 1 |
| 16 | Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha- negative human breast tumors 显示文摘 | Creighton C J Hilger AM Murthy S | 2006 | Cancer Res2006，66，7： | 1 |
| 17 | Mining gene expression databases for association rules显示文摘 | CREIGHTON C HANASH S | 2003 | Bioinformatics2003，19，： | 1 |
| 18 | A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers显示文摘 | Creighton C J | 2007 | BMC Genomics2007，8，： | 1 |
| 19 | Rot2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium显示文摘 | Roarty K Shore A N Creighton C J | 2015 | Journal of Cell Biology2015，208，： | 1 |
| 20 | Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and itsclinical implications in breast cancer显示文摘 | Creighton C J Chang JC Rosen JM | | 0，，2： | 1 |
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