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| 1 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 2 | Growth inhibition by gamma rays affects lipids and fatty acids in garlic sprouts during storage显示文摘 | Mónica B. Pérez Marta I. Avelda?o Clara A. Croci | 2007 | Postharvest Biology and Technology2007，，2： | 1 |
| 3 | Carbon Nanotube Films as Electron Field Emitters 显示文摘 | Bonard J Croci M Klinke C | 2002 | Carbon2002，，40： | 1 |
| 4 | Synovial sarcoma of the extremities:prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance显示文摘 | CAMARGO O P CROCI A T | 2006 | Clinics2006，61，5： | 1 |
| 5 | Isometric ann counter-pressure maneuvers to abort impending vasovagal syncope 显示文摘 | Brignole M Croci F Menozzi C | 2002 | J Am Coil Cardiol2002，40，： | 1 |
| 6 | Respiratory system me- chanics in sedated,paralyzed,morbidly obese patients显示文摘 | Pelosi P Croci M Ravagnan I | 1977 | J Appl Physiol1977，82，3： | 1 |
| 7 | Mass volume measurement in severe head injury: accuracy and feasibility of two pragmatic methods显示文摘 | Stocchetti N Croci M Spagnoli D | 2000 | J Neurol Neurosurg Psychiatry2000，680，： | 1 |
| 8 | The effects of pressurization rate on breathing pattern,work of breathing,gas exchange and patient comfort in pressure support ventilation显示文摘 | Chiumello D Pelosi P Croci M | 2001 | Eur Respir J2001，18，1： | 1 |
| 9 | Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and intcrleukin 10显示文摘 | Ilarregui J M Croci DO Bianco GA ct al | 2009 | Nat Immunol2009，10，9： | 1 |
| 10 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 11 | A Fully Sealed Luminescent Tube Based on Carbon Nanotube Field Emission 显示文摘 | Croci M Arfaoui I Stockli T | 2004 | Microelectronics Journal2004，35，： | 1 |
| 12 | Growth of Carbon Nanotubes on Cylindrical Wires by Thermal Chemical Vapor Deposition 显示文摘 | Noury O Stockli T Croci M | 2001 | Chemical Physics Letter2001，346，： | 1 |
| 13 | Isometric arm counter- pressure maneuvers to abort impending vasovagal syncope 显示文摘 | Brignole M Croci F Menozzi C | 2002 | J Am Coil Cardiol2002，40，11： | 1 |
| 14 | Respiratory system mechanics in sedated, paralyzed, morbidly obese patients 显示文摘 | Pelosi P Croci M Ravagnan I | 1997 | J Appl Physiol1997，82，3： | 1 |
| 15 | The prone positioning during general anesthesia minimally affects respiratory mechanics while improving functional residual capacity and increasing oxygen ten- sion显示文摘 | Pelosi P Croci M Calappi E | 1995 | Anesth Analg1995，80，5： | 1 |
| 16 | The prone posilioning during general anesthesia minimally affects respiratory me- chanics while improving functional residual capacity and in- creasing oxygen tension显示文摘 | Pelosi P Croci M Calappi E | 1995 | Anesth Analg1995，80，5： | 1 |
| 17 | Carbon nanotubes films as electron field emitters 显示文摘 | Bonard J M Croci M Klinke C | 2002 | Carbon2002，40，： | 1 |
| 18 | Pefioperative changes in fimctional residual capacity in morbidly obese patients显示文摘 | Damia e Maschemni D Croci M | 1988 | Br J Anaesth1988，60，： | 1 |
| 19 | Primary bone lymphoma in 24 patientstreated between 1955 and 1999显示文摘 | Pires de Camargo O Machado T M S Croci A T | 2002 | Clin Orthop2002，397，4： | 1 |
| 20 | Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2显示文摘 | RONFANI L FERRAGUTI M CROCI L | 2001 | Development2001，128，： | 1 |
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