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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | The GPⅠa C807T di-morphism associated with platelet collagen receptor density is nota risk factor for myocardial infarction显示文摘 | Croft S A Hampton K K Sorrell J A | 1999 | Br J Haematol1999，106，3： | 1 |
| 3 | Differences in the localization and morphology of chromosomes in the human nucleus显示文摘 | Croft J A Bridger J M Boyle S | 1999 | J Cell Biol1999，145，： | 1 |
| 4 | Estimating the prevalence of low back pain in the general population显示文摘 | Papageorgiou A C Croft P R Ferry S | | 0，，17： | 1 |
| 5 | High-rate uncorrelated bit extraction for shared secret key generation from channel measurements显示文摘 | Patwari N Croft J Jana S | 2010 | IEEE Transactions on Mobile Computing2010，9，1： | 1 |
| 6 | Vibration compensation for high speed scanning tunneling microscopy显示文摘 | Croft D Devasia S | 1999 | Rev Sci Instrum1999，70，12： | 1 |
| 7 | Secret key extraction from wireless signal strength in real environments 显示文摘 | PREMNATH S N JANA S CROFT J | 2013 | I EEE Trans on Mo- bile Computing2013，12，5： | 1 |
| 8 | Creep, hysteresis and vibration compensation for piezoactuators: atomic force microscopy application显示文摘 | Croft D Shed G Devasia S | 2001 | J Dyna Sys Meas Ctrl2001，123，1： | 1 |
| 9 | Central and peripheral adverse hemodynamic changes during laparoscopic surgery and their reversal with a novel intermittent segmential pneumatic compression device显示文摘 | Francis N Crofts S | 2001 | Ann Surg2001，233，： | 1 |
| 10 | Primaquine-loaded poly (lactide) nanoparticules: physicochemical study and acutetolerancein mice显示文摘 | Rodrigues J M Croft S L Fessi H | 1995 | Int J Pharm1995，126，： | 1 |
| 11 | Creep, hysteresis, and vibration compensation for piezoactuators: atomic force microscopy applica- tion 显示文摘 | CROFT D SHED G DEVASIA S | 2001 | Journal of Dynamic Systems Measurement and Control2001，123，1： | 1 |
| 12 | The use of neutron intensity calibrated ^9Be (α,n) sources as 4 438 keV gamma-ray reference standards 显示文摘 | CROFT S | 1989 | Nucl Instrum Methods1989，281，： | 1 |
| 13 | Volatile components of cured and uncured pork: the role of nitrite and the formation of nitrogen compounds显示文摘 | MOTTRAM D S CROFT S E PATTERSON R L S | 1984 | Journal of the Science of Food and Agriculture1984，35，2： | 1 |
| 14 | Tugwell E OARSI recommendations for the management of hip and knee osteoarthritis,part Ⅰ:critical appraisal of existing treatment guidelines and systematic review of current research evidence显示文摘 | Zhang W Moskowitz RW Nuki G Abramson S Altman RD Arden N Bierma-Zeinstra S Brandt KD Croft P Doherty M Dougados M Hochberg M Hunter DJ Kwoh K Lohmander LS | | 0，，09： | 1 |
| 15 | Central and peripheral adverse hemodynamic changes during laparoscopic surgery and their reversal with a novel intermittent sequential pneumatic compression device显示文摘 | Alishahi S Francis N Crofts S | 2001 | Ann Surg2001，233，2： | 1 |
| 16 | Creep, hysteresis, andvibration compensation for piezoactuators:Atomic forcemicroscopy application 显示文摘 | CROFT D SHED G DEVASIA S | 2001 | Journal of Dynamic Systems Measurement and Control2001，123，1： | 1 |
| 17 | Recent advances in research and control of malaria, leishmaniasis,trypanosomiasis and schistoso miasis显示文摘 | Croft SL Vivas L Brooker S | 2003 | East Mediterr Health2003，9，4： | 1 |
| 18 | Vibration compensation for high speed scanning tunneling microscopy显示文摘 | Croft D Devasia S | 1999 | Review of Scientifc Instruments1999，70，12： | 1 |
| 19 | The internal surge in Loch Ness显示文摘 | Thorpe S A Hall A J Croft I | 1972 | Nature1972，237，： | 1 |
| 20 | Central and peripheral adverse hemodynamic changes during laparoscopic surgery and their reversal with a novel intermittent sequential pneumatic compression device 显示文摘 | Alishahi S Francis N Crofts S | 2001 | Ann Surg2001，233，2： | 1 |
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