|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Electrocardiographic markers of cardiac resynchronization therapy response:delayed time to intrinsicoid deflection onset in lateral leads显示文摘Cardiac resynchronization therapy(CRT)has emerged as an important intervention for patients with heart failure(HF)with reduced ejection fraction and delayed ventricular activation.In these patients,CRT has demonstrated to improve quality of life,promote reverse left ventricular(LV)remodeling,reduce HF hospitalizations,and extend survival.However,despite advancements in our understanding of CRT,a significant number of patients do not respond to this therapy.Several invasive and non-invasive parameters have been assessed to predict response to CRT,but the electrocardiogram(ECG)has remained as the prevailing screening method albeit with limitations.Ideally,an accurate,simple,and reproducible ECG marker or set of markers would dramatically overcome the current limitations.We describe the clinical utility of an old ECG parameter that can estimate ventricular activation delay:the onset to intrinsicoid deflection(ID).Based on the concept of direct measurement of ventricular activation time(intrinsic deflection onset),time to ID onset measures on the surface ECG the time that the electrical activation time takes to reach the area subtended by the corresponding surface ECG lead.Based on this principle,the time to ID on the lateral leads can estimate the delay activation to the lateral LV wall and can be used as a predictor for CRT response,particularly in patients with non-specific intraventricular conduction delay or in patients with left bundle branch block and QRS<150 ms.The aim of this review is to present the current evidence and potential use of this ECG parameter to estimate LV activation and predict CRT response. | Rubén KA Tapia-Orihuela S Michael Gharacholou Samuel J Asirvatham Freddy Del-Carpio Munoz | 2022 | Journal of Geriatric Cardiology2022，19，1： | 3 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Persistence of soil organic matter as an e- cosystem property显示文摘 | Michael W I S Margaret S T Samuel A | 2011 | Nature2011，478，7367： | 1 |
| 4 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial显示文摘 | Jayant S Vaidya David J Joseph Jeffrey S Tobias Max Bulsara Frederik Wenz Christobel Saunders Michael Alvarado Henrik L Flyger Samuele Massarut Wolfgang Eiermann Mohammed Keshtgar John Dewar Uta Kraus-Tiefenbacher Marc Sütterlin Laura Esserman Helle MR Ho | 2010 | The Lancet2010，，9735： | 1 |
| 5 | Persistence of soil organic matter as an ecosystem property显示文摘 | Michael W I S Margaret S T Samuel A | 2011 | Nature2011，478，7367： | 1 |
| 6 | First human-caused extinction of a cetacean species?显示文摘 | Turvey Samuel T Pitman Robert L Taylor Barbara L Barlow Jay Akamatsu Tomonari Barrett Leigh A Zhao Xiujiang Reeves Randall R Stewart Brent S Wang Kexiong Wei Zhuo Zhang Xianfeng Pusser L.T Richlen Michael Brandon John R Wang Ding | 2007 | Biology Letters2007，，5： | 1 |
| 7 | Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis显示文摘 | Jamieson Thomas Clarke Mairi Steele Colin W Samuel Michael S Neumann Jens Jung Andreas Huels David Olson Michael F Das Sudipto Nibbs Robert J B Sansom Owen J | 2012 | EN2012，，： | 1 |
| 8 | Long-Term Results of Targeted Intraoperative Radiotherapy (Targit) Boost During Breast-Conserving Surgery显示文摘 | Jayant S. Vaidya Michael Baum Jeffrey S. Tobias Frederik Wenz Samuele Massarut Mohammed Keshtgar Basil Hilaris Christobel Saunders Norman R. Williams Chris Brew-Graves Tammy Corica Mario Roncadin Uta Kraus-Tiefenbacher Marc Sütterlin Max Bulsara David Jos | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，4： | 1 |
| 9 | Tetramethylammonium Chloride as a Selective and Robust Phase Transfer Catalyst in a Solid-liquid Halex Reaction:the Role of Water显示文摘 | YOEL S SAMUEL N MICHAEL R | 1996 | Chem Còmmun1996，，： | 1 |
| 10 | Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial显示文摘 | Gerald S Falchook Georgina V Long Razelle Kurzrock Kevin B Kim Tobias H Arkenau Michael P Brown Omid Hamid Jeffrey R Infante Michael Millward Anna C Pavlick Steven J O’Day Samuel C Blackman C Martin Curtis Peter Lebowitz Bo Ma Daniele Ouellet Richard F Ke | 2012 | The Lancet . 2012 (9829)2012，，9829： | 1 |
| 11 | 身高、体质指数和社会经济地位之关系:对英国生物样本库的孟德尔随机化研究显示文摘目的确定身高、体质指数(BMI)与社会经济状况的5个方面是否存在因果关系。方法孟德尔随机化研究测试身高、BMI与社会经济状况之间的因果关系有何不同。孟德尔随机化方法运用基因型随机分配理论,这样不会受到非基因混杂因素的干扰。 | Jessica Tyrrell Samuel E Jones Robin Beaumont Christina M Astley Rebecca Lovell Hanieh Yaghootkar Marcus Tuke Katherine S Ruth Rachel M Freathy Joel N Hirschhorn Andrew R Wood Anna Murray Michael N Weedon Timothy M Frayling 莫云凌 邓晓春 | 2016 | 英国医学杂志中文版2016，0，7： | 1 |
| 12 | Persistence of soil organic matter as an ecosystem property显示文摘 | Michael W I S Margaret S T Samuel A | 2011 | Nature2011，478，7367： | 1 |
| 13 | Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma显示文摘 | Ma Xiao-Hong Piao Sheng-Fu Dey Souvik Mcafee Quentin Karakousis Giorgos Villanueva Jessie Hart Lori S Levi Samuel Hu Janice Zhang Gao Lazova Rossitza Klump Vincent Pawelek John M Xu Xiaowei Xu Wei Schuchter Lynn M Davies Michael A Herlyn | 2014 | Journal of Clinical Investigation2014，，3： | 1 |
| 14 | Thermodynamics of fenofibrate and solubility in pure organic solvents显示文摘 | Samuel W Sarah H Michael S | 2014 | Fluid Phase Equilibria2014，367，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员