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| 1 | 人工智能干预性临床试验报告指南:CONSORT-AI扩展显示文摘《试验报告统一标准》(Consolidated Standards of Reporting Trials,CONSORT)2010声明提供了报告随机试验的最低准则。它的广泛使用有助于保证评估新的干预措施的透明性。最近,人们越来越认识到,涉及人工智能(artificial intelligence,AI)的干预需要经过严格的前瞻性评估,以明确其对健康的影响。《人工智能试验报告统一标准》(Consolidated Standards of Reporting Trials Artificial Intelligence,CONSORT-AI)是一个新的临床试验报告指南,用以评估具有AI成分的干预。它是与《人工智能干预试验方案报告标准》(Standard ProtocolItems:Recommendations forI nterventional Trials-Artificial Intelligence,SPIRIT-AI)同步编制的。这两项指南的编制通过分阶段的文献回顾和专家咨询等过程达成共识,产生29项候选条目。由国际多方利益相关者小组在两阶段德尔菲调查(103个利益相关者)中对这些条目进行了咨询,并在共识会议上达成一致意见(31个利益相关者),通过34个试点参与进行改进和优化。CONSORT-AI扩展包括14项新条目,这些新条目对于AI干预非常重要,除了2010年CONSORT声明的核心条目之外,试验报告还应常规包含这些内容。CONSORT-AI建议研究人员提供关于AI干预的清晰描述,包括使用AI所需的说明和技能、AI干预集成环境的设置、输入和输出数据处理的注意事项、人-AI交互和错误案例分析。CONSORT-AI将有助于提高AI干预临床试验方案的透明度和完整性,也有助于编辑、同行评审以及普通读者理解、解释和严格评估临床试验的设计和偏倚风险。 | 李子孝(译) 熊云云(译) 丁玲玲(译) 王春雪(译) 赵性泉(译) 王拥军(译) WANG Chun-Juan LIU X X CRUZ RIVERA S MOHER D | 2020 | 中国卒中杂志2020，15，12： | 19 |
| 2 | The effect of environmental contaminants on testicular function显示文摘男繁殖健康在最后几十年更加败坏了。营养,社会经济,生活方式和环境因素(在其它之中) 被归因于损害男繁殖健康。在最近的年里,一条大量证据积累了那建议减少的男富饶的趋势(以精子,计数,质量和其它处于男繁殖健康变化) 可能由于到环境有毒物的暴露。这些环境沾染物能模仿自然雌激素并且指向 Sertoli 和 Leydig 房间的阴囊的精子发生, steroidogenesis,和功能。最环境的有毒物被显示了导致反应的氧种类,从而在睾丸的各种各样的分隔空间引起氧化应力的一个状态。然而,睾丸上的环境有毒物的行动的分子的机制还得被阐明。这评论通过氧化应力和 apoptosis 的正式就职在阴囊的功能上讨论一些更通常使用的环境沾染物的效果。 | Premendu Prakash Mathur Shereen Cynthia D'Cruz | 2011 | Asian Journal of Andrology2011，13，4： | 13 |
| 3 | Effects of plants and plant products on the testis显示文摘几个世纪,植物和基于植物的产品作为药的珍贵、安全的生来的来源被使用了治疗各种各样的疾病。大多数这些植物的治疗学的潜力能被归功于到他们的 anticancer, antidiabetic, hepatoprotective, cardioprotective,镇痉药,止痛剂和许多其他的药理学性质。然而,几通常使用的植物被报导了不利地在野生动物和人影响男繁殖功能。与大多数植物和基于植物的产品观察的效果被归因于 antispermatogenic 或至少一活跃成分的 antisteroidogenic 性质。这评论在睾丸在各种各样的目标房间上讨论一些通常使用的植物的有害效果。进这些自然混合物的行动的分子的机制的更深的卓见能为对他们的毒性开发治疗学的策略铺平道路。 | Shereen Cynthia D'Cruz Selvaraju Vaithinathan Rajamanickam Jubendradass Premendu Prakash Mathur | 2010 | Asian Journal of Andrology2010，12，4： | 6 |
| 4 | Cumulative positive fluid balance is a risk factor for acute kidney injury and requirement for renal replacement therapy after liver transplantation显示文摘AIM To analyze whether fluid overload is an independent risk factor of adverse outcomes after liver transplantation(LT).METHODS One hundred and twenty-one patients submitted to LT were retrospectively evaluated.Data regarding perioperative and postoperative variables previously associated with adverse outcomes after LT were reviewed.Cumulative fluid balance(FB) in the first 12 h and 4 d after surgery were compared with major adverse outcomes after LT.RESULTS Most of the patients were submitted to a liberal approach of fluid administration with a mean cumulative FBover 5 L and 10 L,respectively,in the first 12 h and 4 d after LT.Cumulative FB in 4 d was independently associated with occurrence of both AKI and requirement for renal replacement therapy(RRT)(OR = 2.3;95%CI:1.37-3.86,P = 0.02 and OR = 2.89;95%CI:1.52-5.49,P = 0.001 respectively).Other variables on multivariate analysis associated with AKI and RRT were,respectively,male sex and Acute Physiology and Chronic Health Disease Classification System(APACHE II) levels and sepsis or septic shock.Mortality was shown to be independently related to AST and APACHE II levels(OR = 2.35;95%CI:1.1-5.05,P = 0.02 and 2.63;95%CI:1.0-6.87,P = 0.04 respectively),probably reflecting the degree of graft dysfunction and severity of early postoperative course of LT.No effect of FB on mortality after LT was disclosed.CONCLUSION Cumulative positive FB over 4 d after LT is independently associated with the development of AKI and the requirement of RRT.Survival was not independently related to FB,but to surrogate markers of graft dysfunction and severity of postoperative course of LT. | Liana Codes Ygor Gomes de Souza Ricardo Azevedo Cruz D'Oliveira Jorge Luiz Andrade Bastos Paulo Lisboa Bittencourt | 2018 | World Journal of Transplantation2018，8，2： | 4 |
| 5 | 系统性红斑狼疮显示文摘系统性红斑狼疮(SLE)的临床表现可以是慢性致残性的,严重者可以发生重要脏器的功能衰竭,甚至危及生命,早期诊断是改善预后的关键,抗磷脂(Hughes)综合征通常继发于SLE,可以导致病人反复发生血栓和流产,抗疟药、小剂量糖皮质激素和免疫抑制剂的治疗通常有效,新近出现的一些药物,如霉酚酸酯和生物制剂可能为SLE治疗带来更多的选择和希望,外源性补充雌激素导致狼疮复发的风险性可能低于预想的情况,但是仍然会增加血栓形成的危险性,加速性动脉粥样硬化仍然是目前存在的问题。 | David P D’Cruz 张卓莉 | 2006 | 英国医学杂志中文版2006，9，4： | 4 |
| 6 | Gel-microemulsion as vaginal spermicides and intravaginal drug delivery vehicles显示文摘 | D'Cruz OJ Uckun FM | 2001 | Contraception2001，64，： | 2 |
| 7 | Chitosan microparticles as injectable scaffolds for tissue engineering 显示文摘 | CRUZ D M IVIRICO J L GOMES M M | 2008 | J Tissue Eng Regen Med2008，2，6： | 1 |
| 8 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 9 | Clay mineral assemblages in flysch from the Campo de Gibraltar area( Spain ) 显示文摘 | Cruz M D R | 1999 | Clay Mineralogy1999，34，2： | 1 |
| 10 | Pulmonary renal vasculitis syndromes显示文摘 | Lee RW D'Cruz DP | 2010 | Autoimmun Rev2010，9，10： | 1 |
| 11 | Amphotericin B therapy: past, present, and future 显示文摘 | Peacock J E Herrington D A Cruz J M | 1993 | Infect Dis Clin Pract1993，2，： | 1 |
| 12 | Typical diffusion behaviour in packaging polymers?-?application to functional barriers显示文摘 | Dole P Feigenbaum A E Cruz C D L | 2006 | Food Additives and Contaminants2006，23，2： | 1 |
| 13 | Aneurysmal ('angiomatoid') fibrous histioeytoma of the skin 显示文摘 | Santa Cruz D J Kyriakos M | 1981 | Cancer1981，47，8： | 1 |
| 14 | Distinct roles of isoforms of the heme-liganded nuclear receptor E75, an insect ortholog of the vertebrate Rev-erb, in mosquito reproduction 显示文摘 | Cruz J Mane-Padros D Zou Z | 2012 | Molecular and Cellular Endocrinology2012，349，2： | 1 |
| 15 | Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor ac- tivation显示文摘 | D' Cruz B J Fertig KC Filiano AJ | 2002 | J Cereb Blood Flow Metab2002，22，7： | 1 |
| 16 | Nuclear receptor BgFTZ-F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect Blattella germanica显示文摘 | Cruz J Nieva C Mané-Padrós D | | 0，，11： | 1 |
| 17 | Highly Efficient Liquefaction of Woody Biomass in Hot-Compressed Alcohol-Water Co-solvents显示文摘 | Cheng S D'cruz I Wang M | 2010 | Energy & Fuels2010，24，9： | 1 |
| 18 | Virtual and interactive environments for work of the future 显示文摘 | John R Wilson Mirabelle D' Cruz | 2006 | International Journal of Human - Computer Studies2006，，： | 1 |
| 19 | Immunosuppressive therapy in lupus nephritis显示文摘 | HOUSSIAU FA VASCONCELOS D' CRUZ D | 2002 | Arthritis Rheum2002，，46： | 1 |
| 20 | Probiotic DairyProducts as Functional Foods显示文摘 | GRANATO D BRANCO G F CRUZ A G | 2010 | Comprehensive Reviews in FoodScience and Food Safety2010，9，5： | 1 |
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