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| 1 | Oncogenic role of leptin and Notch interleukin-1 leptin crosstalk outcome in cancer显示文摘Obesity is a global pandemic characterized by high levels of body fat(adiposity) and derived-cytokines(i.e., leptin). Research shows that adiposity and leptin provide insight on the link between obesity and cancer progression. Leptin's main function is to regulate energy balance. However, obese individuals routinely develop leptin resistance, which is the consequence of the breakdown in the signaling mechanism controlling satiety resulting in the accumulation of leptin. Therefore, leptin levels are often chronically elevated in human obesity. Elevated leptin levels are related to higher incidence, increased progression and poor prognosis of several human cancers. In addition to adipose tissue, cancer cells can also secrete leptin and overexpress leptin receptors. Leptin is known to act as a mitogen, inflammatory and pro-angiogenic factor that induces cancer cell proliferation and tumor angiogenesis. Moreover, leptin signaling induces cancer stem cells, which are involved in cancer recurrence and drug resistance. A novel and complex signaling crosstalk between leptin, Notch and interleukin-1(IL-1) [Notch, IL-1 and leptin crosstalk outcome(NILCO)] seems to be an important driver of leptin-induced oncogenic actions. Leptin and NILCO signaling mediate the activation of cancer stem cells that can affect drug resistance. Thus, leptin and NILCO signaling are key links between obesity and cancer progression. This review presents updated data suggesting that adiposity affects cancer incidence, progression, and response to treatment. Here we show data supporting the oncogenic role of leptin in breast, endometrial, and pancreatic cancers. | Crystal C Lipsey Adriana Harbuzariu Danielle Daley-Brown Ruben R Gonzalez-Perez | 2016 | World Journal of Methodology2016，6，1： | 8 |
| 2 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | Optimal injection points for the neuromuscular blockade of forearm flexor muscles:a cadaveric study 显示文摘 | Roberts C Crystal R Eastwood D M | 2006 | J Pediatr Orthop B2006，15，5： | 1 |
| 4 | CEO Compensation as Tournament and Social Comparison: A Tale of Two Theories 显示文摘 | O'Reilly C A Main B G Crystal G S | 1988 | Administrative Science Quarterly1988，33，2： | 1 |
| 5 | Correlations of synaptic and pathological markers with cognition of the elderly 显示文摘 | Dickson DW Crystal HA Bevona C | 1995 | Neuro- bio! Aging1995，16，3： | 1 |
| 6 | Compassion satisfaction, burn out, and compassion fatigue among emergency nurses compared with nurses in other selected inpatient Specialties 显示文摘 | Crystal H Janet C David R | 2010 | J Emerg Nurs2010，36，5： | 1 |
| 7 | Coping, conflietual social interactions, social support, and mood among HIV-infected persons 显示文摘 | FLEISHMAN J A SHERBOURNE C D CRYSTAL S | 2000 | Am J Comm Psychol2000，28，4： | 1 |
| 8 | CEO compensation as tournament and social comparison: a tale of two theories 显示文摘 | O'Reilly C A Main B G Crystal G S | 1988 | Administrative Science Quarterly1988，33，2： | 1 |
| 9 | The functional anatomy of ventricular contraction显示文摘 | Crystal DK Wagner C | 1953 | Circ Res1953，1，： | 1 |
| 10 | Ramsay Hunt Syndrome With Severe Dysphagia显示文摘 | Crystal C Michael F Adam R | 2012 | Journal of Voice2012，1，： | 1 |
| 11 | Insul- in-like growth factor binding protein-1 at the maternal-fetal interface and insulin-like growth factor-1, insulin-like growth factor- Ⅱ,and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia显示文摘 | Giudice L C Martin N A Crystal R A | 1997 | Am J Obstet Gynecol1997，176，4： | 1 |
| 12 | Stress, Social Support, and Distress in a Statewide Population of Persons with AIDS in New Jersey显示文摘 | Crystal S Kersting R C | 1995 | Soc Work Health Care1995，28，1： | 1 |
| 13 | Where's the risk in CEO's Rewards? 显示文摘 | Crystal C S | 1988 | Fortune1988，，12： | 1 |
| 14 | Toll-like receptor agonists shape the immune responses to a mannose receptor-targeted cancer vaccine显示文摘以前的研究记录了蛋白质抗原的那选择交货到表示甘露糖受体(先生) 的房间能导致提高的有免疫力的回答。我们要求了那影响了 MR 表达式水平的代理人,和介绍房间的表示先生的抗原的激活和移植地位,将调制有免疫力的回答到指向先生的疫苗。探讨这个问题,我们在人的先生调查了临床上使用的助手的效果转基因( hMR-Tg )与一支指向先生的癌症疫苗使免疫的老鼠与 oncofetal 蛋白质熔化的人的反先生 monoclonal 抗体 B11 创作了,人的 chorionic gonadotropin 贝它链( hCGβ ;),并且叫作 B11-hCGβ ;。我们发现那体液的回答到 B11-hCGβ 的低剂量;能被 GM-CSF 的优先的管理提高,它在 vivo 的 upregulated 先生表示。然而,像使用费的受体(TLR ) 的合作管理有 B11-hCGβ 的收缩筋, poly-ICLC 或 CpG;被要求得到 Th1 免疫,由 IFN-γ 的抗原特定的 T 房间生产测量了。TLR 收缩筋被显示在使免疫的 hMR-Tg 老鼠的排干的淋巴节点增加疫苗包含的房间的数字。特别地,与 B11-hCGβ并且 poly-ICLC,疫苗积极的房间的戏剧的增加在淋巴节点的 T 房间区域被观察,与与 GM-CSF 独自一个或联合的疫苗相比。重要地, TLR 收缩筋的缺席在 priming 免疫期间导致了抗原特定的忍耐。因此,这研究提供卓见进助手能由扩充有免疫力的回答到 B11-hCGβ 的机制;并且为临床的研究的基本原理设计有含意把指向先生的种痘与 TLR 收缩筋相结合。 | Li-Zhen He Jeffrey Weidlick Crystal Sisson Henry C Marsh Tibor Keler | 2015 | Cellular & Molecular Immunology2015，12，6： | 1 |
| 15 | Menstrual cycle and dietary restraint influence taste preferences in young women 显示文摘 | Frye C A Crystal S Ward K D | 1994 | Physiol Behav1994，55，3： | 1 |
| 16 | CEO compensation as tournament and social comparison: A tale of two theories显示文摘 | O'Reilly III C A Main B G Crystal G S | 1988 | Administrative Science Quarterly1988，，： | 1 |
| 17 | Psychological Anteced- ents of Promotive and Prohibitive Voice: A Two-wave Examination显示文摘 | LIANG J CRYSTAL I C F | 2012 | Academy of Management Journal2012，55，1： | 1 |
| 18 | Broadened use of atypical antipsychotics:safety,effectiveness,and policy challenges显示文摘 | Crystal S Olfson M Huang C | 2009 | Health Affairs2009，28，5： | 1 |
| 19 | A Comparison of unconstraining methods to improve revemm management systems 显示文摘 | Crystal C Ferguson M Higbie J and Kapoor R | 2007 | Production and Operations Management2007，16，6： | 1 |
| 20 | Modulation of neurotoxic behavior in F 344 rats by temporal disposition of benzo( a ) pyrene显示文摘 | CRYSTAL R S ARAMANDLA R DOLORES C S | 2002 | Toxieol Lett2002，129，12： | 1 |
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