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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Multiple Solutions for P- Laplacian Type Equations显示文摘 | Kristaly A Lisei H Csaba Varga C | 2008 | Nonlinear Analysis Theory Methods & Applications2008，68，5： | 1 |
| 4 | The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis显示文摘 | Krisztina Horváth Csaba Varga Anikó Berkó Anikó Pósa Ferenc László Brendan J.R. Whittle | 2007 | European Journal of Pharmacology2007，，3： | 1 |
| 5 | Multiple solutions for p-laplaeian type equations显示文摘 | Alexandru Kristaly Hannelore Lisei Csaba Varga | 2008 | Nonlinear Analy sis Theory Methods & Applications2008，68，5： | 1 |
| 6 | Multiple solutions for p-Laplacian type equations 显示文摘 | Alexandru Kristaly Hannelore Lisei Csaba Varga | 2008 | Nonlinear Analysis2008，68，： | 1 |
| 7 | Common and conflicting objectives and practices of herders and conservation managers:the need for a conservation herder显示文摘The mutual dependence of extensive land-use and conservation management has become appar-ent in Europe in the last 20-30 yr.Extensive land-use often survives in protected areas only,in the form of conservation management.Knowledge of extensive herding and that of conservation management are parts of two knowledge systems(traditional and scientific)which often leads to conflicts between locals and con-servationists.We studied two herding/conservation systems(salt steppes and wood-pastures),and devel-oped an inventory on the common/similar and conflicting/different objectives and pasture management practices of herders and conservationists.Data were collected by participatory knowledge co-production in teamwork of the co-authors(herders,conservation managers,and scientists).Data were analyzed and discussed in teamwork too.Herders and conservationists identified 23 objectives and 29 management prac-tices.We found a number of common interests with respect to herding,the ideal state of pastures,legal provisions,and communication.Conflict resolution recommendations(e.g.,on time and place of grazing,pasture improvements)were also developed.We argue that by co-production of knowledge,and establish-ment of a herder“school”the mitigation of the existing conflicts would be more effective.Our conclusion is that a new profession is needed:that of the conservation herder.The conservation herder shall be an indi-vidual knowledgeable about herding and pasture management,trained in conservation and ecology,able to design management experiments,and develop novel but tradition-based management practices.As such,he/she could facilitate adaptation of extensive herding in the changing socio-economic environment. | Zsolt Molnar Jozsef Kis Csaba Vadasz Laszlo Papp Istvan Sandor Sandor Beres Gabor Sinka Anna Varga | 2016 | Ecosystem Health and Sustainability2016，2，4： | 0 |
| 8 | 矿泉浴疗预防学:新的研究方法显示文摘这篇文章描述了一种研究矿泉浴疗在预防医学中应用的策略。以预防为目的矿泉浴及饮用矿泉水是能够应用于人群中开展流行病学分析的。应用完全的化学分析(包括高精确有机分析)及特定毒性试验检测医疗矿泉水样本和医疗泥样本,可以计算出预防应用矿泉疗法的毒理学风险。 | 张倩 王江 Csaba Varga | 2011 | 中国疗养医学2011，20，11： | 0 |
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