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		题名	作者	年代	出处	被引量
	1	Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option.	Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres	2012	World Journal of Gastroenterology2012，18，25：	5
	2	Regulation of fibronectin matrix assembly and capillary morphogenesis in endothelial cells by rho family gtpases 显示文摘	Fernandez-Sauze S Grall D Cseh B	2009	Exp Cell Res2009，315，12：	1
	3	The 'RAF' neighborhood: Protein-protein interaction in the Raf/ Mek/Erk pathway显示文摘	CSEH B DOMA E BACCARINI M	2014	FEBS Lett2014，，：	1
	4	'RAF'neighborhood:Protein protein interaction in the Raf/Mek/Erk pathway显示文摘	Cseh B Doma E Baccarini M	2014	FEBS Lett2014，588，15：	1
	5	The'RAF' neighborhood:Protein-protein interaction in the Raf/Mek/Erk pathway显示文摘	Cseh B Doma E Baccarini M	2014	FEBS Lett2014，1588，15：	1
	6	Indentation creep in a short fibre-reinforced metal matrix composite显示文摘	G Cseh J B?r H.-J Gudladt J Lendvai A Juhász	1999	Materials Science & Engineering A1999，，1：	1
	7	Chronic stress decreases the number of parvalbumin-immunorcactive interneurons in the hippoeampus:prevention by treatment with a substance P receptor (NK1) antagonist显示文摘	Cseh B Simon M van derHart M G	2005	Neuropsychopharmacology2005，30，1：	1
	8	Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor- binding sites detected with comparative promoter analysis 显示文摘	Vasarhelyi B Cseh A Kocsis I	2006	Mol Hum Repord2006，12，1：	1
	9	Effect of 3 months of doxazosin therapy on T-cell subsets in type 2 diabetic patients显示文摘	Mácsai E Cseh A Budai G Mészáros G Vásárhelyi B Fischer K Szabó A Treszl A	2009	J Int Med Res2009，37，6：	1
	10	Akt enzyme:new therapeutictarget in Cancer and diabetes?显示文摘	Cseh A Szebeni B Szalay B	2009	Orv Hetil2009，150，8：	1
	11	Three mechanisms in the pathogenesis of pre-eclampsia suggested by over- represented transcription factor-binding sites detected with comparative promoter analysis显示文摘	V a s a rhelyi B Cseh A Kocsis I	2006	Mol Hum Reprod2006，12，1：	1
	12	Adaptive immunity in ankylosing spondylitis:phenotype and functional alterations of T-cells before and during infliximab therapy显示文摘	Szalay B Mészáros G Cseh		0，，：	1

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