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| 1 | Negative pressure pulmonary oedema after septoplasty 显示文摘 | Garcfa de Hombre AM Cuffini A Bonadeo A | 2013 | Acta Otorrinolaringol Esp2013，64，4： | 1 |
| 2 | Effect of rufloxacin upon non-specific immune defence:in-vitro,ex-vitro and in vivo results显示文摘 | Tullio V Alloco A | 1994 | J Antimicrob Chemother1994，34，4： | 1 |
| 3 | Effect of rufloxacinupon non-specificimmune defences: in-vitro, ex-vivo and in-vivo results显示文摘 | Cuffini AM Tullio V Allocco A | 1994 | J Antimicrob C hemother1994，34，： | 1 |
| 4 | Effect of ruf|oxacin upon non-specific immune defence~ in- vitro, e~vivo, and in-vivo results显示文摘 | Cuffini A M Tullio V Allocco A | 1994 | Jantimicrob Chemother1994，34，54： | 1 |
| 5 | Effect of ru- floxacin upon non-specific immune defence: in-vitro, ex-vivo,and in-vivo results显示文摘 | Cuffini A M Tullio V Allocco A | 1994 | J Antimicrob Che- mother1994，34，4： | 1 |
| 6 | Effect of rufloxacin upon non-specific immune defence: in-vitro, ex-vivo and invivo results显示文摘 | Cuffini AM Tullio V AUocco A | 1994 | Journal of Antimicrobial Chemotherapy1994，34，4： | 1 |
| 7 | Effect of rufloxacin upon non-specific immune defence:in-vitro,ex-vivo and in-vivo results显示文摘 | Tullio V Allocco A | 1994 | Journal of antimicrobial chemotherapy1994，34，4： | 1 |
| 8 | Irbesartan desmotropes:Solid-state characterization,thermodynamic study and dissolution properties显示文摘Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer). Studies have reported that IBS is a polymorphic system and its forms A and B are related monotropically. These reports indicate form B as the most stable and less soluble form. Therefore, the goal of this contribution is to demonstrate through a complete solid-state characterization, thermodynamic study and dissolution properties that the IBS forms are desmotropes that are not related monotropically. However, the intention is also to call attention to the importance of conducting strict chemical and in solid-state quality controls on the IBS raw materials. Hence, powder X-ray diffraction (PXRD) and Raman spectroscopy (RS) at ambient and non-ambient conditions, differential scanning calorimetry (DSC), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM) techniques were applied. Furthermore, intrinsic dissolution rate (IDR) and structural stability studies at 98% relative humidity (RH), 25℃ and 40 ℃ were conducted as well. The results show that in fact, form A is approximately four-fold more soluble than form B. In addition, both IBS forms are stable at ambient conditions. Nevertheless, structural and/or chemical instability was observed in form B at 40℃ and 98% RH. IBS has been confirmed as a desmotropic system rather than a polymorphic one. Consequently, forms A and B are not related monotropically. | Andrea Mariela Araya-Sibaja Carlos Eduardo Maduro de Campos Cinira Fandaruff Jose Roberto Vega-Baudrit Teodolito Guillen-Giron Mirtha Navarro-Hoyos Silvia Lucía Cuffini | 2019 | Journal of Pharmaceutical Analysis2019，9，5： | 0 |
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