3篇
您的检索式：作者名="Cui Jianghua"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxygen absorption properties of YBaCo4O7-type compounds 显示文摘 | Hao Haoshan Cui Jianghua Chen Changqing | 2006 | Solid State lonics2006，177，： | 1 |
| 2 | Autophagy-related protein ATG5 regulates histone H2B mono-ubiquitylation by translational control of RNF20显示文摘Autophagy is an evolutionarily conserved lysosome-mediated catabolic process(Klionsky,2007).Autophagy is believed to be essential for cell survival,especially when cells were exposed to stresses,such as nutrient starvation.The activation of autophagy under starvation allows cells to survive by providing essential crudes for cell construction via degrading intracellular | Xin Huang Lu Yang Feng-Feng Cai Yufei Wang Ping Chen Jiangsheng Mi Chenghua Yu Jianghua Lai Xiaojun Zhang Shuguang Wei Wen Cui Su Chen | 2017 | Journal of Genetics and Genomics2017，44，10： | 1 |
| 3 | Remodeling Isoprene Pyrophosphate Metabolism for Promoting Terpenoids Bioproduction显示文摘Terpenoids are the largest family of natural products.They are made from the building block isoprene pyrophosphate(IPP),and their bioproduction using engineered cell factories has received a great deal of attention.To date,the insufficient metabolic supply of IPP remains a great challenge for the efficient synthesis of terpenoids.In this work,we discover that the imbalanced metabolic flux distribution between the central metabolism and the IPP supply hinders IPP accumulation in Bacillus subtilis(B.subtilis).Therefore,we remodel the IPP metabolism using a series of genetically encoded two-input-multioutput(TIMO)circuits that are responsive to pyruvate or/and malonyl-CoA,resulting in an IPP pool that is significantly increased by up to four-fold.As a proof-of-concept validation,we design an IPP metabolism remodeling strategy to improve the production of three valuable terpenoids,including menaquinone-7(MK-7,4.1-fold),lycopene(9-fold),andβ-carotene(0.9-fold).In particular,the titer of MK-7 in a 50-L bioreactor reached 1549.6 mg·L^(-1),representing the highest titer reported so far.Thus,we propose a TIMO genetic circuits-assisted IPP metabolism remodeling framework that can be generally used for the synergistic fine-tuning of complicated metabolic modules to achieve the efficient bioproduction of terpenoids. | Xianhao Xu Xueqin Lv Shixiu Cui Yanfeng Liu Hongzhi Xia Jianghua Li Guocheng Du Zhaofeng Li Rodrigo Ledesma-Amaro Jian Chen Long Liu | 2023 | Engineering2023，，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员