3篇
您的检索式：作者名="Cuicui Zhuang"
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| 1 | Equivalent efficacy study of QL1101 and bevacizumab on untreated advanced non-squamous non-small cell lung cancer patients: a phase 3 randomized, double-blind clinical trial显示文摘Objective:This phase 3 study aimed to test equivalence in efficacy and safety for QL1101,a bevacizumab analogue in Chinese patients with untreated locally advanced non-squamous non-small cell lung cancer(NSCLC).Methods:Eligible patients were randomly assigned 1:1 to receive carboplatin and paclitaxel in combination with either QL1101 or bevacizumab,15 mg/kg every 3-week for 6 cycles.This was followed by maintenance treatment with single agent QL1101 every 3-week.The primary end-point was objective response rate(ORR),with secondary end-points being progression-free survival(PFS),overall survival(OS),disease control rate(DCR),and adverse events(AEs).Results:Of 675 patients,535 eligible patients were randomized to the QL1101 group(n=269)and bevacizumab group(n=266).ORRs were 52.8%and 56.8%,respectively,for the QL1101 and bevacizumab groups,with an ORR hazard ratio 0.93(95%confidence interval:0.8-0131.1).The PFS,OS,DCR,and AEs were comparable between the 2 groups,which remained the same after stratification according to epidermal growth factor receptor mutation or smoking history.Conclusions:QL1101 showed similar efficacy and safety profiles as compared to bevacizumab among Chinese patients with untreated locally advanced non-squamous NSCLC. | Tianqing Chu Jun Lu Minghong Bi Helong Zhang Wu Zhuang Yan Yu Jianhua Shi Zhendong Chen Xiaochun Zhang Qisen Guo Quan Liu Huijuan Wu Jian Fang Yi Hu Xiuwen Wang Cuicui Han Kai Li Baohui Han | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 2 | Boron-assisted growth of silica nanowire arrays and silica microflowers for bendable capacitor application显示文摘Aligned silica nanowire arrays and silica microflowers were fabricated using boron as the catalyst and under the flow N2 gas. The obtained product had no catalyst contamination. And silica nanowires had long lengths of a few hundreds. The growth of nanowire arrays and microflowers was explained using mechanism. Parallel-plate capacitors using silica nanowire mat as the dielectric were fabricated. The silica nanowire capacitor shows a specific capacitance of 0.24 n F/cm^2 at the frequency of 100 Hz. The capacitor is not monotone changing with the frequency. The measurement of mechanical properties shows that the tunneling current increases along with an increase in bending angle of the capacitor. | Cuicui Zhuang Ling Li Yang Liu Chuncheng Ban Xiaowei Liu | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
| 3 | Microwave Induced Ethanol Bath Bonding for PMMA Microfluidic Device显示文摘High bonding strength,low deformation and convenient procedure are all very important aspects in the microfluidic device fabrication process. In this paper,an improved microwave induced bonding technology is proposed to fabricate microfluidic device based on methyl methacrylate( PMMA). This method employs pure ethanol as the bonding assisted solvent. The ethanol not only acts as the microwave absorbing material,but also works as the organic solvent in bath. The presented research work has shown that the bonding process can be completed in less than 45 s. Furthermore,the convenient bonding only applies microwave oven,beakers and binder clips. Then,we discuss effects of microwave power,bonding time on bonding strength and deformation of microstructures on PMMA microfluidic device. Finally,a 4 layers micro-mixer has been fabricated using the proposed bonding technique which includes 15 trapezoid micro-channels,9 T-type mix units and an X-type mix unit. Experimental results show that the proposed bonding method have some advantages compared with several traditional bonding technologies,such as hot pressing bonding,ultrasonic bonding and solvent assisted bonding methods in respect of bonding strength,deformation and bonding process. The presented work would be helpful for low coat mass production of multilayer polymer microfluidic devices in lab. | Xiaowei Han Xiaowei Liu Li Tian He Zhang Cuicui Zhuang | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，2： | 0 |
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