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| 1 | Electrospun Ru ( bpy ) : + ) -doped nation nanofibers for electrochamilumines- cence sensing 显示文摘 | Zhou Cuisong Liu Zhen Dai Jianyuan | 2010 | Analyst2010，135，5： | 1 |
| 2 | In situ syn- thesis of gold nanoparticles on porous polyacrylonitrile nanofi- bers for sensing applications 显示文摘 | Liu Zhen Zhou Cuisong Zheng Baozhan | 2011 | Analyst2011，136，21： | 1 |
| 3 | Detection of oncoprotein platelet-derived growth factor using a fluorescent signaling complex of an aptamer and TOTO显示文摘 | Cuisong Zhou Yaxin Jiang Shuang Hou Baocheng Ma Xiaohong Fang Menglong Li | 2006 | Analytical and Bioanalytical Chemistry2006，，5： | 1 |
| 4 | sufentanil for clinical observation of patient controlled subcutaneous analgesia 显示文摘 | Yao Cuisong Li Huizhen | 2009 | modern Chinese medicine application2009，3，16： | 1 |
| 5 | Electrospun Ru ( bpy ) 2+3 -doped nation nanofibers for cence sensing 显示文摘 | Zhou Cuisong Liu Zhen Dai Jianyuan | 2010 | Analyst2010，135，5： | 1 |
| 6 | In situ synthesis of gold nanoparticles on porous polyacrylonitrile nanofibers for sensing applications 显示文摘 | Liu Zhen Zhou Cuisong Zheng Baozhan | 2011 | Analyst2011，136，21： | 1 |
| 7 | Single-molecule investigation of human telomeric G-quadruplex interactions with Thioflavin T显示文摘G-quadruplex ligands have been accepted as potential therapeutic agents for anticancer treatment.Thioflavin T(ThT), a highly selective G-quadruplex ligand, can bind G-quadruplex with a fluorescent light-up signal change and high specificity against DNA duplex. However, there are still different opinions that ThT induces/stabilizes G-quadruplex foldings/topologies in human telomere sequence. Here, a sensitive single-molecule nanopore technology was utilized to analyze the interactions between human telomeric DNA(Tel DNA) and ThT. Both translocation time and current blockade were measured to investigate the translocation behaviors. Furthermore, the effects of metal ion(K^+ and Na^+) and pH on the translocation behaviors were studied. Based on the single-molecule level analysis, there are some conclusions:(1) In the electrolyte solution containing 50 mmol/L KCI and 450 mmol/L NaCl, ThT can bind strongly with Tel DNA but nearly does not change the G-quadruplex form;(2) In the presence of high concentration K^+,the ThT binding induces the structural change of hybrid G-quadruplex into antiparallel topology with an enhanced structural stability;(3) In either alkaline or acidic buffer, G-quadruplex form will change in certain degree. All above conclusions are helpful to deeply understand the interaction behaviors between Tel DNA and ThT. This nanopore platform, investigating G-quadruplex ligands at the single-molecule level, has great potential for the design of new drugs and sensors. | Honglian Cai Cuisong Zhou Qiufang Yang Tingting Ai Yuqin Huang You Lv Jia Geng Dan Xiao | 2018 | Chinese Chemical Letters2018，29，3： | 1 |
| 8 | Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells显示文摘Influenza A virus(IAV),responsible for seasonal epidemics and recurring pandemics,represents a global threat to public health.Given the risk of a potential IAV pandemic,it is increasingly important to better understand virushost interactions and develop new anti-viral strategies.Here,we reported nonmuscle myosin IIA(MYH9)-mediated regulation of IAV infection.MYH9 depletion caused a profound inhibition of IAV infection by reducing viral attachment and internalization in human lung epithelial cells.Surprisingly,overexpression of MYH9 also led to a significant reduction in viral productive infection.Interestingly,overexpression of MYH9 retained viral attachment,internalization,or uncoating,but suppressed the viral ribonucleoprotein(vRNP)activity in a minigenome system.Further analyses found that excess MYH9 might interrupt the formation of vRNP by interacting with the viral nucleoprotein(NP)and result in the reduction of the completed vRNP in the nucleus,thereby inhibiting subsequent viral RNA transcription and replication.Together,we discovered that MYH9 can interact with IAV NP protein and engage in the regulation of vRNP complexes,thereby involving viral replication.These findings enlighten new mechanistic insights into the complicated interface of host-IAV interactions,ultimately making it an attractive target for the generation of antiviral drugs. | Jian Chen Jian Liu Zhilu Chen Daobin Feng Cuisong Zhu Jun Fan Shuye Zhang Xiaoyan Zhang Jianqing Xu | 2023 | Virologica Sinica2023，38，1： | 0 |
| 9 | A designed locked nucleic acid-based nanopore for discriminating ctDNA and its coexisting analogue ncDNA显示文摘Circulating tumor DNA(ctDNA),carrying tumor-specific sequence mutations,is a promising biomarker for classification,diagnosis and prognosis of cancers.However,there is still a great challenge in discriminating single-base difference between ctDNA and its coexisting analogue(normal circulating DNA,ncDNA)at a serum sample.A locked nucleic acid(LNA)probe combined with a-HL nanopore sensor was designed,which achieved a high signal-to-background ratio(SBR)of^8.34 × 10^3,as well as a significant discrimination capability(~12.3 times)of single-base diffe rence.The accurate discrimination strategy is label-free,convenient,selective and sensitive,which has great potential in the early diagnosis of diseases and biomedical research fields. | Yuqin Huang You Lv Jia Geng Dan Xiao Cuisong Zhou | 2020 | Chinese Chemical Letters2020，31，1： | 0 |
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