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4篇 您的检索式:作者名="Cuiyan Wu"
    题名 作者 年代 出处 被引量
1Generation of transgenic cucumbers with expression of a ten-tandem repeat long-acting GLP-1 analogue and their biological function on diabetic rats显示文摘Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone, which has the regulatory function of stimulating the secretion of insulin to balance blood glucose levels. In this study, marker-free expression vector pX6 with a fusion gene of ten tandem repeated GLP-1 analog ([Ser8, Gln26 and Asp34]-GLP-1) genes was constructed and transformed into cucumbers by Agrobacterium tumefaciens-mediated transformation method. Four transgenic lines were obtained by PCR and Southern blotting analysis and two transgenic lines successfully expressed the fusion protein (named GLP-T), which was revealed by Western blotting analysis. The biological activity test results showed that the serum glucose level of diabetic rats was significantly decreased after oral administration of the fusion protein GLP-T extracted from the transgenic cucumber fruitage. These results suggest that this may provide a brand-new strategy to prevent and cure the diabetes with no pain.ZHAO Lei LIAO Fang WANG CuiYan CHEN Miao WEI AiMin DU ShengLi MA BaiCheng HU XiaoYu WU ZhiQiang WANG RuiJu LI MingGang 2009Chinese Science Bulletin2009,54,24:2
2Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and antiangiogenic activities in gender-specific gene expression in Keshan disease显示文摘He Shulan Tan Wuhong Wang Sen Wu Cuiyan Wang Pan Wang Bin Su Xiaohui Zhao Junjie Guo Xiong Xiang Youzhang 2014Chinese Medical Journal2014,,1:2
3Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin–Beck disease and primary osteoarthritis显示文摘Jingjing Zheng Cuiyan Wu Weijuan Ma Yongtao Zhang Tiezhou Hou Honghai Xu Shixun Wu Xiao Yao Xiong Guo 2013International Orthopaedics2013,,:1
4Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages显示文摘Dear Editor,Psychiatric disorders are a group of mental disorders characterized by psychological or behavioral disabilities.Losing of the ability to work and assuming the extensive cost of long-term treatment,patients with psychiatric disorders are forced to support a heavy financial and medical burden.The growth and development of brain structures are dynamic,and different brain structures have major and specific functions to control behavior and performance.Xin Qi Cuiyan Wu Yanan Du Shiqiang Cheng Yan Wen Mei Ma Chujun Liang Li Liu Bolun Cheng Lu Zhang Ping Li Feng Zhang 2020Neuroscience Bulletin2020,36,9:0
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