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| 1 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 2 | Catalytic properties of early transition metal nitrides and carbides:n-butane hydrogenolysis,dehydrogenation and isomerization显示文摘 | NEYLON M K CHOI S KWON H CURRY K E THOMPSON L T | 1999 | Appl Catal A1999，183，2： | 1 |
| 3 | A-type granites: geochemical characteristics, discrimination and petrogenesis 显示文摘 | Whalen J B Currie K L Chappell B W | 1957 | Contrib Mineral Petrol1957，95，： | 1 |
| 4 | The epidemiology and cost of inpatient care for peripheral vascular disease, infec- tion, neuropathy, and ulceration in diabetes 显示文摘 | Currie C J Morgan C L L Peters J R | 1998 | Diabetes care1998，21，1： | 1 |
| 5 | An unusual peralkaline granite near Lac Brisson, Quebec-Labrador显示文摘 | Currie K L | 1985 | Geological Survey of Canada1985，85，1： | 1 |
| 6 | UV induced photocatalytic degradation of azo dyes by organic-capped ZnO nanocrystals immobilized onto substrates显示文摘 | Comparelli R Fanizza E Curri M L | 2005 | Applied Catalysis B: Environmental2005，60，12： | 1 |
| 7 | Solving multidimensional knapsack problems with generalized upper bound constraints using critical e-vent tabu search显示文摘 | Li V C Curry C L | 2005 | Computers & Operations Research2005，32，4： | 1 |
| 8 | A guide to biological skin substitutes显示文摘 | Jones I Currie L Martin L | 2002 | BrJ Plast Surg2002，55，： | 1 |
| 9 | The determination of hemodialysis blood recirculation using blood urea nitrogen measurements 显示文摘 | Hester R L Curry E Bower J | 1992 | Am J Kidney D s1992，20，： | 1 |
| 10 | Pattern recognition of the pul- monary manifestations of AIDS on CT scans显示文摘 | Sider L Gabriel H Curry DR | 1993 | Radiographics1993，13，4： | 1 |
| 11 | Chicken-sized oviraptoric dinosaurs from central China and their ontogeneticimplications 显示文摘 | Lti J Currie P J Xu L | 2013 | Natursissenschaften2013，100，2： | 1 |
| 12 | Development of anovel enzyme/semiconductor nanoparticles system for biosensor application显示文摘 | Curri M L Agostiano A Leo G | 2002 | Materials Science and Engineering:C2002，22，2： | 1 |
| 13 | Stable carbon and oxygen isotope compositions of mollusc shells from Britain and New Zealand显示文摘 | Mitchell L Fallick A E Curry G B | 1994 | Palaeogeogr Palaeoclimatol Palaeoecol1994，111，34： | 1 |
| 14 | Chronic consumption of rebaudioside A,a steviol glycoside,in men and women with type 2 diabetes mellitus显示文摘 | MAKIA K C CURRY L L REVESA M S | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 15 | A-type granites: Geochemical characteristics, discrimination and petrogensis 显示文摘 | WHALEN J B CURRIE K L CHAOCELL B W | 1987 | Contr Mineral Peteol1987，95，： | 1 |
| 16 | Rate of spread of surface fires in ponderosa pine type of California显示文摘 | Curry J R Fons W L | 1938 | Journal of Agricultural Research1938，57，： | 1 |
| 17 | A-type granites:geochemical characteristics,discrimination and petrogenesis显示文摘 | Whalen J B Currie K L Chappell B W | 1987 | Contributions to Mineralogy and Petrology1987，95，： | 1 |
| 18 | A-type granites: Geochemical characteristics, discrimination and petrogenesis显示文摘 | Whalen J B Currie K L Chappell B W | 1987 | Contributions to Mineralogy and Petrology1987，95，4： | 1 |
| 19 | investigation on alcohol vapours/TiO2 nanocrystal thin films interaction by SPR technique for sensing application 显示文摘 | MANERA M G LEO G CURRI M L | 2004 | Sens Actuators B2004，100，： | 1 |
| 20 | Crustal stress determination from boreholes and rock cores: Fundamental principles显示文摘 | Schmitt D R Currie C A Zhang L | 2012 | Tectonophysics2012，580，： | 1 |
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