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| 1 | Transradial versus transfemoral access for anterior circulation mechanical thrombectomy: analysis of 375 consecutive cases显示文摘Objective To compare transradial artery access(TRA)to the gold standard of transfemoral artery access(TFA)in mechanical thrombectomy(MT)for stroke caused by anterior circulation large vessel occlusion.Methods The clinical outcomes,procedural speed,angiographic efficacy and safety of both techniques were analysed in 375 consecutive cases over an 18-month period in a high volume statewide neurointerventional service.Results There was no significant difference in patient characteristics,stroke parameters,imaging techniques or intracranial techniques.The median time elapsed between CT scanning and reperfusion was 96.5 min(IQR 68-123)in the TFA group and 95 min(IQR 68-123)in the TRA group(p=0.456).Of 336 patients who were independent at presentation 58%(124/214)of the TFA group and 67%(82/122)of the TRA group had a modified Rankin score of 0-2 at 90-day follow-up(p=0.093).Cross-over from radial to femoral was 4.6%(4/130)compared with 1.6%cross-over from femoral to radial(4/245),but did not meet the predetermined level of statistical significance(OR2.92,95% CI 0.81 to 10.52,p=0.088) and did not impact median procedural speed.Adequate angiographic reperfusion,first pass reperfusion,embolisation to new territory and symptomatic intracranial haemorrhage were similar in both groups.There was a significant difference in major access site complications requiring an additional procedure.None of the TRA cases had a major access site complication but 6.5%(16/245)of the TFA cases did(p=0.003).Conclusion This study suggests that using TRA for anterior circulation MT is fast,efficacious,safe and not inferior to the gold standard of TFA. | Timothy John Phillips Matthew Thomas Crockett Gregory D Selkirk Ruchi Kabra Albert Ho Yuen Chiu Tejinder Singh Constantine Phatouros William McAuliffe | 2021 | Stroke & Vascular Neurology2021，6，2： | 7 |
| 2 | Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: Studies in vitro and in conditionally transgenic mice显示文摘AIM: To investigate a specific association between hepatic steatosis and hepatitis C virus (HCV) core. METHODS: HeLa cells and primary mouse hepatocytes were transfected with HCV core plasmid, and conditional transgenics in which hepatic over-expression of HCV core is regulated by the tetracycline-off system, were developed. The expression of the HCV core was assessed over one to six months after withdrawal of doxycycline (dox) by immunohistochemistry (IHC) and Western blotting and by sequential liver biopsy. Hepatic steatosis was evaluated using oil red stain. 8-hydroxydeoxyguanosine (8-OHdG) stains and caspase levels were conducted to clarify hepatic oxidative stress and apoptosis rate. Serum aminotransferase was checked. RESULTS: The transfected hepatocytes had globular cores under the lipid vesicles. In transgenic mice on control diet, core expression was robust, localized to the cytoplasmic vesicle membrane and strongly associatedwith microvesicular steatosis, which was gradually replaced by macrovesicular steatosis. However, both steatosis and core positive hepatocytes diminished with time. Increases in aminotransferase, caspase and 8-OHdG were associated with peak core expression. CONCLUSION: The core protein was readily detected and morphologically associated with steatosis in individual hepatocytes both in vitro and in vivo. In vivo, oxidative stress caused by the core potentially reduced the number of core positive hepatocytes and in parallel the level of steatosis. To our knowledge, this is the f irst animal model that directly shows topological relationship between HCV core and hepatic lipid vesicles. | Ming-Ling Chang Jeng-Chang Chen Chau-Ting Yeh I-Shyan Sheen Dar-In Tai Ming-Yu Chang Cheng-Tang Chiu Deng-Yn Lin D Montgomery Bissell | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Two heuristics for scheduling multiple projects with resource constraints显示文摘 | TSAI D M CHIU H N | 1996 | Construction Management and Economies1996，14，4： | 1 |
| 5 | Erythroeyte membrane lipid reorganization during the sickling process显示文摘 | Chiu D Lubin B Shohet SB | 1979 | Br J Haematol1979，41，2： | 1 |
| 6 | Uncertainties inflow modeling and for encasing for Niagara River 显示文摘 | Chiu Chao-lin Crissman R D Yu W | 1993 | Journal of Hydraulic Engineering ASCE1993，119，11： | 1 |
| 7 | Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis 显示文摘 | Nozawa H Chiu C Hanahan D | 2006 | Proc Natl Acad Sci USA2006，103，12： | 1 |
| 8 | The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) : stenting versus carotid endarterectomy for carotid disease显示文摘 | Mantese V A Timaran C H Chiu D | 2010 | Stroke2010，41，10： | 1 |
| 9 | Shape optimized electro-optic beam scanners:analysis, design, and simulation 显示文摘 | CHIU Yi ZOU Jie STANCIL D D | 1999 | Journal of Lightwave Technology1999，17，1： | 1 |
| 10 | Subcutaneous fat necrosis of the newhom complicating hypothermic cardiac surgery 显示文摘 | CHUANG S D CHIU H C CHANO C C | 1995 | Br J Dermatol1995，132，5： | 1 |
| 11 | A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant显示文摘 | Koh Y K K Chiu T Y Boobis A R Cartmell E Pollard S J T Scrimshaw M D I_ester J N | 2008 | Chemosphere2008，73，4： | 1 |
| 12 | A fuzzy multi-criteria decision making approach for solving a bi-objective personnel assignment problem显示文摘 | Huang D K Chiu H N Yeh R H | 2009 | Computers & Industrial Engineering2009，56，1： | 1 |
| 13 | Applications of industrial ecology:an overview of the special issue显示文摘 | KORHONEN J HUISINGH D CHIU A S F | 2004 | Jounal of Cleaner Production2004，12，8910： | 1 |
| 14 | Challenges, design and analysis of a large-scale P2P-VoD system显示文摘 | HUANG YAN FU T Z J CHIU D M | 2008 | ACM SIGCOMM Computer Communication Review2008，38，4： | 1 |
| 15 | Induction of vascular endothelial phenotype and cellular proliferation from human cord blood stem cells cultured in simulated microgravity 显示文摘 | Chiu B Wan J Z Abley D | 2005 | Acta Astronaut2005，56，912： | 1 |
| 16 | Osteometry of the Chinese proximat femur 显示文摘 | Fang D Chiu KY Remedios ID | 1996 | J Orthop Surg1996，4，2： | 1 |
| 17 | 查看详情显示文摘 | Keller U Miller D A B Boyd G D Chiu T H Ferguson J F Asom M T | | 0，，： | 1 |
| 18 | Synthesizing Statistical Knowledge from Incomplete Mixed-mode Data 显示文摘 | Wong A K C Chiu D K Y | 1987 | IEEE Transactions on Pattern Analysis and Machine Intelligence1987，9，6： | 1 |
| 19 | Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease 显示文摘 | BIANCHI M G BARDELLI D CHIU M | 2014 | Cellular and Molecular Life Sciences2014，71，11： | 1 |
| 20 | Subcutaneous fat necrosis of the newborn complicating hypothermic surgery显示文摘 | CHUANG S D CHIU H C CHANG C C | 1995 | Br J Dermatol1995，132，5： | 1 |
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