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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 3 | 局灶节段透明变性及硬化在判断IgA肾病预后中的意义显示文摘目的 探讨IgA肾病 (IgAN)进展为慢性肾功能不全 (CRI)的病理学危险因素。方法 对 6 40例经肾活检确诊的IgAN病人进行平均 5 3个月的追踪观察。用病例对照法研究所有病人的病理学资料 ,同时还对其中 2 0 4例活检当时肾功能正常 ,5年后发展为CRI或终末期肾功能衰竭(ESRF) (n =18)以及 5年后肾功能仍保持正常 (n =186 )的病例进行了比较。结果 弥漫性系膜增生型 (DMP)为最常见的病理型 ,占 5 0 %。 / 间质纤维化 ,>40 %硬化肾小球 , / 血管病变 ,局灶节段透明变性及硬化 (FSHS)的均为预测肾功能恶化的危险因素 ,其中FSHS的意义更大 (P <0 0 0 0 1)。结论 FSHS的存在是IgAN病人正常肾功能进展恶化的显著指标。 | 严海东 Packham D Kincaid Smith P Becker G 周希静 | 1999 | 中华肾脏病杂志1999，15，5： | 20 |
| 4 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 5 | Restriction fragment length polymorphism evaluation of six peanut species within the Arachis section显示文摘 | Paik Ro O G Smith R L Knauft D A | 1992 | Theor Appl Genet1992，84，： | 2 |
| 6 | Descriptors of corneal shape显示文摘 | Lindsay R Smith G Atchison D | 1998 | Opt Vis Sci1998，75，2： | 2 |
| 7 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 8 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 9 | The effect of restorative materials on the wear of human enamel 显示文摘 | Retledge D K Smith B G N Wilson R F | 1994 | J Prosthet Dent1994，72，2： | 2 |
| 10 | Novel 1xN and NxN Integrated Optical Switches Using Self-lmaging Multimode GaAs/Al-GaAs Waveguides显示文摘 | Jenkins R M Heaton J M Wright D R Parker J T Birbeck J C H Smith G W Hilton K P | 1994 | Appl Phys Lett 71994，64，： | 1 |
| 11 | The shape and internal s tructure of the moon from the clementine mission 显示文摘 | D E Smith F G Lemoine at el | 1994 | Science1994，226，： | 1 |
| 12 | Acute arterial occlusion afterultrasound guided thrombin injection of a common femoral arterypseudoaneurysm with a wide, short neck 显示文摘 | D'Ayala M Smith R Zanieski G | 2008 | Ann Vase Surg2008，22，3： | 1 |
| 13 | Measuring thermal and mechanical stresses on optical fiber in a DC module using fiber Bragg gratings显示文摘 | Glaesemann G S Smith J A Clark D A | 2005 | Journal of Lightwave Technology2005，23，11： | 1 |
| 14 | Kinetic cooling of a gas by absorption of CO2 laser radiation显示文摘 | Gebhardt F G Smith D C | 1972 | Appl Phys Lett1972，20，3： | 1 |
| 15 | 显示文摘 | HERBST D SMITH D ADAMS N G | 1989 | J Chem Soc Fraday Trans1989，285，10： | 1 |
| 16 | The Shape and Internal Structure of the Moon from the Clementine Mission显示文摘 | Zuber M T Smith D E Lemoine F G | 1994 | Science1994，266，： | 1 |
| 17 | Cardioprotection with kappa - opioid receptor stimulation is associated with a slowing of cross -bridge cycling显示文摘 | Pyle W G Smith T D Hofmann P A | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 1 |
| 18 | High refractive index hybrid ceramet materials prepared from tetraisoprpoxide and poly (arylene ether phosphine oxide) through sol-gel processing 显示文摘 | WANG B WILKES G L SMITH C D | 1991 | Polymer Comm1991，32，1： | 1 |
| 19 | Emergence and predominance of an H5N1 influenza variant in China 显示文摘 | Smith G J D Fan X H Wang J | 2006 | Proc Natl Acad Sci USA2006，103，16： | 1 |
| 20 | RAPD marker and isozyme characterization of Sphaeropsis sapinea from diverse coniferous hosts and locations 显示文摘 | Stanosz G R Swart W J Smith D R | 1999 | Mycological Research1999，103，9： | 1 |
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