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| 1 | Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer显示文摘AIM: To compare the efficacy of capecitabine and oxaliplatin (XELOX) with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX6) in gastric cancer patients after D2 dissection. METHODS: Between May 2004 and June 2010, patients in our gastric cancer database who underwent D2 dissection for gastric cancer at the First Affiliated Hospital of Sun Yat-Sen University were retrospectively analyzed. A total of 896 patients were enrolled into this study according to the established inclusion and exclusion criteria. Of these patients, 214 received the XELOX regimen, 48 received FOLFOX6 therapy and 634 patients underwent surgery only without chemotherapy. Overall survival was compared among the three groups using Cox regression and propensity score matchedpair analyses. RESULTS: Patients in the XELOX and FOLFOX6 groups were younger at the time of treatment (median age 55.2 years; 51.2 years vs 58.9 years), had more undifferentiated tumors (70.1%; 70.8% vs 61.4%), and more lymph node metastases (80.8%; 83.3% vs 57.7%), respectively. Overall 5-year survival was 57.3% in the XELOX group which was higher than that (47.5%) in the surgery only group (P = 0.062) and that (34.5%) in the FOLFOX6 group (P = 0.022). Multivariate analysis showed that XELOX therapy was an independent prognostic factor (hazard ratio = 0.564, P < 0.001). After propensity score adjustment, XELOX significantly increased overall 5-year survival compared to surgery only (58.2% vs 44.2%, P = 0.025) but not compared to FOLFOX6 therapy (48.5% vs 42.7%, P = 0.685). The incidence of grade 3/4 adverse reactions was similar between the XELOX and FOLFOX6 groups, and more patients suffered from hand-foot syndrome in the XELOX group (P = 0.018). CONCLUSION: Adjuvant XELOX therapy is associated with better survival in patients after D2 dissection, but does not result in a greater survival benefit compared with FOLFOX6 therapy. | Ying Wu Zhe-Wei Wei Yu-Long He Roderich E Schwarz David D Smith Guang-Kai Xia Chang-Hua Zhang | 2013 | World Journal of Gastroenterology2013，19，21： | 14 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 4 | CXCR4 regulates growth of both prima ry and metastatic breast cancer显示文摘 | Smith M C Luker K E Garbow J R Prior J L Jackson E Piwnica-Worms D | 2004 | Cancer Res2004，64，： | 1 |
| 5 | Hyperspectral vegetation indices and their relationship with agricultural crop characteristics 显示文摘 | Thenkabail P S Smith R B Pauw E D | 2000 | Remote Sensing of Environment2000，71，： | 1 |
| 6 | The shape and internal s tructure of the moon from the clementine mission 显示文摘 | D E Smith F G Lemoine at el | 1994 | Science1994，226，： | 1 |
| 7 | Growth of SiC Epitaxial Layers on Porous Surfaces of Varying Porosity显示文摘 | Saddow S E Mynbaeva M Smith M C D | 2001 | Applied Surface Science2001，184，： | 1 |
| 8 | Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at lltitude 显示文摘 | SMITH E M D BAILLIE J K THOMPSON A A R | 2006 | High Altitude Medicine & Biology2006，7，3： | 1 |
| 9 | A mechanism for divalent cation regulation of beta 3-integrins显示文摘 | Smith J W Piotrowicz R E Mathis D | 1994 | J Bio Chem1994，269，： | 1 |
| 10 | Sequential preoperative or postoperative docetaxel added to preoperative doxorubicin plus cyclophosphamide for operable breast cancer:National Surgical Adjuvant Breast and Bowel Project Protocol B-27显示文摘 | BEAR H D ANDERSON S SMITH R E | 2006 | J Clin Oncol2006，24，13： | 1 |
| 11 | Autonomic and myocardial changes in middle cerebral artery occlusion:Stroke models in the rat显示文摘 | Cechetto D F Wilson J X Smith K E | 1989 | Brain Res1989，502，： | 1 |
| 12 | The Shape and Internal Structure of the Moon from the Clementine Mission显示文摘 | Zuber M T Smith D E Lemoine F G | 1994 | Science1994，266，： | 1 |
| 13 | Microstructural characterization of Ni-Mn-Ga ferromagnetic shape memory alloy powders显示文摘 | SOLOMON V C SMITH D J TANG Y J BERKOWITZ A E | 2004 | J Appl Phys2004，95，： | 1 |
| 14 | Identification of glutenin alleles in wheat and triticale using PCR-generated DNA markers 显示文摘 | SMITH R L SCHWEDER M E BARNETT R D | 1994 | Crop Science1994，34，： | 1 |
| 15 | Phytoremediation显示文摘 | Salt D E Smith R D Raskin I | 1998 | Annual Review of Plant Physiology and Plant Molecular Biology1998，49，： | 1 |
| 16 | Glycine max: a potential hostof the peanut web blotch fungus显示文摘 | Smith D H McGee R E | 1981 | Proceedings of theAmerican Peanut Research and Education Society1981，，13： | 1 |
| 17 | Phytoremediafion of medals: using plants to remove pollutants fi'om the environment显示文摘 | Raskin I Smith R D Salit D E | 1997 | Current Opinion in Biotechnology1997，8，2： | 1 |
| 18 | C4 plant fromthe Pliocene 显示文摘 | Nambudiri E M V Tidwell W D Smith B N | 1978 | Nature1978，276，81： | 1 |
| 19 | Effects of market and regulatory changes on livestock manure management in southern Alberta显示文摘 | SMITH E G CARD G YOUNG D L | 2006 | Canadian Journal of Agricultural Conomics2006，54，2： | 1 |
| 20 | Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuarine sediments 显示文摘 | Long E R MacDonald D D Smith S L | 1996 | Environmental Management1996，19，1： | 1 |
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