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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Intrathecal polymer-based interleukin- 10 gene delivery for neuropathic pain 显示文摘 | Milligan E D Soderquist R G Malone S M | 2006 | Neuron Glia Biol2006，2，4： | 1 |
| 3 | Sedation and analgesia in adult patients: evaluation of a staged-dose system based on body weight for use in abominal interventional radiology显示文摘 | Stephen J S Malone D E | 2000 | Radiology2000，216，3： | 1 |
| 4 | Annual cycle of dissolved silicate in Chesapeake Bay: implications for the production and fate of phytoplankton biomass显示文摘 | Conley D J Malone T C | 1992 | Mar Ecol Prog Ser1992，81，： | 1 |
| 5 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 6 | Back to basics:valida-tion of the admission systemic inflammatory response syndrome score inpredicting outcome in trauma显示文摘 | Malone DL Kuhls D Napolitano LM | 2001 | J Trauma2001，51，3： | 1 |
| 7 | Magnetic resonance ima ging of the liver: consensus statement from the 1st Interna tional Primovist User meeting 显示文摘 | Malone D Zech CJ Ayuso C | 2008 | Eur Radiol Suppl2008，18，4： | 1 |
| 8 | Prescribers' knowledge of and sources of information for potential drug-drug interactions:A postal survey of US prescrib- ers显示文摘 | Ko Y Malone D C Skrepnek G H | 2008 | Drug Saf2008，31，6： | 1 |
| 9 | First -trimester or second-trimester screening, or both, for Down syndrome显示文摘 | Fergal D Malone Canick Jacob A Robert H | 2005 | N Engl Med2005，353，19： | 1 |
| 10 | Prevalence and significance of retinopathy in subjects with type 1 diabetes of less than 5 years' duration screened for the diabetes control and complications trial Diabetes Care显示文摘 | Malone J I Morrison A D Pavan P R | 2001 | 24(3):522-5262001，24，3： | 1 |
| 11 | Identification of a universal group B Streptococcus vaccine by multiple genome screen 显示文摘 | Malone D Margarit I Rinaudo CD | 2005 | Science2005，309，5731： | 1 |
| 12 | Annual cycle of dissolved silicate in Chesapeake Bay:implications for the production and fate of phytoplankton biomass显示文摘 | Conley D J Malone T C | 1992 | Marine Ecology Progress Series1992，81，： | 1 |
| 13 | Paraquat poisoning;a review of nineteen cases显示文摘 | Malone J D Carmody M Keogh B | 1971 | J Ir Med Assoc1971，64，405： | 1 |
| 14 | Knowledge management A model for organizational learning显示文摘 | Malone D | 2002 | International Journal of Accounting Information Systems2002，13，1： | 1 |
| 15 | Psychiatry and the military: an update显示文摘 | Ritchie E C Benedek D Malone R | 2006 | Psychiatry Clin North Am2006，29，3： | 1 |
| 16 | Perioperative anemia: an in- dependent risk factor tbr infection, mortality, and resource uti- lization in surgery 显示文摘 | l)unne JR Malone D Tracy JK | 2002 | J Surg Res2002，，10： | 1 |
| 17 | Impact of maternal age on obstetric outcome 显示文摘 | Cleary-Goldman J Malone F D Vidaver J | 2005 | Obstet Gynecol2005，105，51： | 1 |
| 18 | First-trimester nasal bone evaluation for aneuploidy in the general population显示文摘 | Malone F D | 2004 | Obstet Gynecol2004，104，6： | 1 |
| 19 | Obstetrics complications and cesarean delivery rate--a population based screening study 显示文摘 | Weiss JX Malone FD Emig D | 2004 | Am J Obstet Gynecol2004，190，： | 1 |
| 20 | A steam cycling model for gas production from a hydrate reservoir显示文摘 | BAYLES G A SAWYER W K MALONE R D | 1986 | Chem Eng Commun1986，47，： | 1 |
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