|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Comparative study of propylene polymerization using Me2Si(Rind)2ZrCl2/SiO2-SMAO/AlR3 and Me2Si(RInd)2ZrCl2/MAO(R=Me, H)显示文摘 | Franceschini F C da R Tavares T T dos Santos J H Z | 2007 | Polymer2007，48，7： | 1 |
| 3 | A structured proteomic approach identifies 14-3-3Sigma as a novel and reliable protein biomarker in panel based differential diagnostics of liver tumors 显示文摘 | Reis H Putter C Megger DA | 2015 | Biochim Biophys Acta2015，1854，6： | 1 |
| 4 | Preparation and enhanced photo- electrochemical performance of coupled bicomponent ZnO - TiO2 nanoeomposites 显示文摘 | C Da Z Hao H Song | 2008 | J Phys C hem C2008，112，： | 1 |
| 5 | Nitrogen incorporation into titanium diboride films deposited by dc magnetron sputtering: Structural modifications 显示文摘 | SANCHEZ C M T FONSECA-FILHO H D MAIA DA COSTA M E H | 2009 | Thin Solid Films2009，517，19： | 1 |
| 6 | Remote-con- trolled magnetic pulmonary vein isolation using a new three-dimensional non-fluoroscopic navigation system: a single-centre prospective study 显示文摘 | Da Costa A Ben H'dech M Romeyer-Bouchard C | 2013 | Arch Cardiovasc Dis2013，106，89： | 1 |
| 7 | En-ergy requirement for maintenance and gain for twogenotypes of quails housed in different breeding rea-ring systems 显示文摘 | FILHO J J DA SILVA J H V SILVA C T | 2011 | Revista Brasileira de Zootecnia2011，40，11： | 1 |
| 8 | Study of the preparation and catalytic performance of molybdenum carbide catalysts prepared with C2H2/H2 carburizing mixture显示文摘 | XIAO T C WANG H T DA J W COLEMAN K S GREEN M L | 2002 | J Catal2002，211，1： | 1 |
| 9 | Detailed aH and 13C NMR structural assignment of three biologically active lignan lactones 显示文摘 | Vladimir C G H Rosangela da S Susimaire P | 2006 | Spectroehim Aeta PartA2006，63，： | 1 |
| 10 | Single-beat estimation of end-systolic pressure-volume relation in humans显示文摘 | Senzaki H Chen C Kass DA | 1996 | Circulation1996，94，10： | 1 |
| 11 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 12 | The nucleus accumbens as a complex of functionally distinct neuronal ensembles:an integr-ation of behavioral,electrophysioligical and anatomical data显示文摘 | Pennartz C M Groenewegen H J Lopes da Sliva F H | 1994 | Prog Neurobiol1994，42，6： | 1 |
| 13 | Identification of potential cell-surfaceproteins in Candida albicans and investigation of the role of aputative cell-surface glycosidase in adhesion and virulence显示文摘 | Alberti-Segui C Morales A J Xing H Kessler M M Willins DA Weinstock K G | 2004 | Yeast2004，21，： | 1 |
| 14 | Identification of pumpkin populations as resistance sources against the Zucchini yellow virus (ZYMV)显示文摘 | Moura M da C C L Zerbini E M da Silva D J H de Queiroz M A | 2005 | Horticultura Brasileira2005，23，： | 1 |
| 15 | The nuclear topography of abl, bcr, PML and RARa genes : evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation显示文摘 | Neves H Ramos C da Silva M G | 1999 | Blood1999，93，： | 1 |
| 16 | 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block显示文摘 | Fritsch C Hoebeke J Dali H Ricchiuti V Isenberg DA Meyer O | 2006 | Arthritis Res Ther2006，8，1： | 1 |
| 17 | The use of headspace solid phase microextraction for the characterization of volatile compounds in olive oil matrices显示文摘 | Ribeiro L H Freitas A M C Gomes da Silva M D R | 2008 | Talanta2008，77，1： | 1 |
| 18 | Daytime variation in performance and tiredness/sleepiness ratings in patients with insomnia, narcolepsy, sleep apnea and normal controls显示文摘 | Schneider C Fu Schulz H | 2004 | J Sleep Res2004，13，4： | 1 |
| 19 | The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzhe- imer' s disease 显示文摘 | Campos H C da Rocha M D Viegas F P | 2011 | CNS Neurol Disord Drug Targets2011，10，2： | 1 |
| 20 | Genetic parameters for growth and reproductive traits of Can- chim breed 显示文摘 | Borba L H F Rey F S B da Silva L O C | 2011 | Pesquisa Agropecu Bras2011，46，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员