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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | 3xP3-EGFP maker facilitates screening for transgenic silkworm Bombyx moriL, from the embryonic stage onwards 显示文摘 | THOMAS J L DA ROCHA M BESSE A | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 4 | Widely linear adaptive equalization of digital communication channel 显示文摘 | de Aquino F J A Resende L S da Rocha C A F | 2010 | IEEE Latin America Transactions2010，8，1： | 1 |
| 5 | Novel propellant-driven inhalation formulations:engineering polar drug particles with surface-trapped hydrofluoroalkane-philes显示文摘 | Wu L A1-Haydari M da Rocha SR | | 0，，02： | 1 |
| 6 | Structural evolution of the Brazilian airport network显示文摘 | da Rocha L E | 2009 | Journal of Statistical Mechanics: Theory and Experiment2009，4，04： | 1 |
| 7 | Mechanical and Rheological Properties of Composites Based on Polyolefin and Mineral Additives 显示文摘 | A L N da Silva M C G Rocha M A R Moraes | 2002 | Polymer Testing2002，，21： | 1 |
| 8 | Molecular characterization and fumonisin production by Fusarium verticillioi-des isolated from corn grains of different geographic origins in Brazil 显示文摘 | De Oliveira Rocha L Reis G M Da Silva V N | 2011 | International journal of food microbiology2011，145，1： | 1 |
| 9 | Effects of carbon and nitrogen sources on the proteome of Pseudomonas aeruginosa PA1 during rhamnolipid production显示文摘 | REIS R S da ROCHA S L G CHAPEAUROUGE D A | 2010 | Process Biochem2010，45，9： | 1 |
| 10 | Inhibition of asphaltene precipitation in Brazilian crude oils using new oil soluble amphiphiles显示文摘 | Rocha Junior L C Ferreira M S Da Silva Rarnos A C | 2006 | Journal of Petroleum Science and Engineering2006，51，12： | 1 |
| 11 | 3 × P3-EGFP marker facilitates screening for transgenic silkworm, Bombyx mor/L, from the embryonic stage onwards显示文摘 | Thomas J L Da Rocha M Besse A | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 12 | Unlimited access to low-energy diet causes acute malnutri- tion in dams and alters biometric and biochemical parameters in offs!aring显示文摘 | do Nascimento E de Santana Muniz G das Graqas de Santana Muniz M de Souza Alexandre L da Rocha LS Leandro CG | 2014 | J Dev & Health Dis2014，5，1： | 1 |
| 13 | Combustion synthesis of high-energy ball-milled Nb+3Al powder mixtures显示文摘 | NETO R M L DA ROCHA C J AMBROZIO F | 2003 | Advanced Powder Technology Ⅲ2003，416，4： | 1 |
| 14 | Exogenous ornithine is an effective precursor and theδ-ornithine amino transferase pathway contributes to proline accumulation under high N recycling in salt-stressed cashew leaves显示文摘 | da Rocha I M Vitorello V A Silva J S Ferreira-Silva S L Viégas R A Silva E N Silveira J A | 2012 | J Plant Physiol2012，169，1： | 1 |
| 15 | Effect of surfactants on the interfacial tension and e- mulsion formation between water and carbon dioxide 显示文摘 | Sandro R P da Rocha Kristi L Harrison Keith P Johns- ton | 1999 | Langmuir1999，15，2： | 1 |
| 16 | TOXOCARIASIS OF THE CNS SIMULATING ACUTE DISSEMINATED ENCEPHALOMYELITIS显示文摘 | C Marx J Lin M R. Masruha M G. Rodrigues A J. da Rocha L C.P. Vilanova A A. Gabbai | 2007 | Neurology2007，，8： | 1 |
| 17 | from the embryonic stage onwards 显示文摘 | Thomas JL Da Rocha M Besse A et aL 3xP3-EGFP marker facilitates screening of transgenic silkworm Bombyx mori L | 2002 | Insect Biochem Mol Biol2002，32，： | 1 |
| 18 | Study of rheologieal behavior of elastomer/polypropylene blends 显示文摘 | Da silva A L N Rocha M C G Coutinho F M B etal | 2002 | Polymer Testing2002，21，3： | 1 |
| 19 | Hepatoprotective effects of pecan nut shells on ethanol-induced liver damage 显示文摘 | Miiller L G Pase C S Reckziegel P Barcelos R C Boufleur N Prado A C Fett R Block J M Pavanato M A Bauermann L F da Rocha J B Burger iV/E | 2013 | Experimental and Toxicologic Pathology: Official2013，65，12： | 1 |
| 20 | Design of CIC filters for software radio system显示文摘 | De Aquino F J A Da Rocha C A F Resende L S | 2006 | IEEE Interbational Conference on Acoustics Speech and Signal Processing2006，3，： | 1 |
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