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| 1 | A high strength pH responsive supramolecular copolymer hydrogel显示文摘Constructing high strength pH sensitive supramolecular polymer hydrogel remains very challenging due to the unavoidable network swelling caused by ionization of acid or basic groups at a specified pH.In this work,we proposed a simple and very convenient approach to fabricate high strength pH responsive supramolecular polymer(SP) hydrogels by one-pot copolymerization of N-acryloyl glycinamide(NAGA) and 2-vinyl-4,6-diamino-1,3,5-triazine(VDT),two feature hydrogen bonding monomers.In these PNAGA-PVDT SP hydrogels obtained,the hydrogen bonding of NAGA was shown to play a dominant role in reinforcing strength,while the hydrogen bonding of diaminotriazine served as a pH sensitive moiety.At pH 3,the mechanical properties of PNAGA-PVDT hydrogels decreased to a different extent due to the breakup of hydrogen bonding;in contrast,the hydrogel resumed the original strength while pH was raised to 7.4 because of reconstruction of hydrogen bonding.Over the selected pH range,the PNAGA-PVDT hydrogels exhibited up to 1.25 MPa tensile strength,845% breaking strain,69 kPa Young's modulus and 21 MPa compressive strength.This novel high strength pH-responsive SP hydrogels may find applications in biomedical and industrial fields. | WANG Qing ZHANG YinYu DAI XiYang SHI XiaoHuan LIU WenGuang | 2017 | Science China(Technological Sciences)2017，60，1： | 6 |
| 2 | Considering Monopoly Maintenance Cost for an Automobile Purchase in China: A DEA-Based Approach显示文摘With the fast growing economy,China has become the biggest automobile market in the world.Many Chinese families buy automobiles to promote individual wellbeing and facilitate the convenience of lives.Automobile purchase has become a general and important decision for a Chinese family.However,it is always difficult to make a decision on the automobile purchase that balance the automobiles performance and its cost.Moreover,the automobile maintenance market in China is monopolistic.Thus,the maintenance cost is a significant consideration in automobile purchase decision.This paper employs the concept of data envelopment analysis(DEA)to measure cost performance of the automobile with considering the monopoly maintenance cost.The RCA(ratio of the total price of accessories of an automobile to the price of the automobile)100 index system is used to represent the maintenance cost of each automobile.The structure of the automobile maintenance market can be reflected with including the RCA 100 index system in the performance evaluation.Results of the case study of 28 automobiles in China verify the necessity of considering the maintenance cost in automobile purchase decision. | DAI Qianzhi LI Lin LEI Xiyang AN Qingxian TANG Xiao | 2019 | Journal of Systems Science & Complexity2019，32，4： | 3 |
| 3 | A Novel Ratio-Based Parallel DEA Approach for Evaluating the Energy and Environmental Performance of Chinese Transportation Sectors显示文摘As a high-energy-consumption and high-CO2-emission industry in China,the transportation sector has been under increasing pressure to improve its performance.This paper develops a novel parallel DEA approach to measure Chinese transportation sector's energy and environmental performance (EEP) over all possible weights,which is to avoid the risk of using the extreme or the most favorable weights in performance evaluation.In our method,the transportation sector is consisted of two parallel subsystems (passenger transportation and freight transportation) with shared inputs and undesirable shared outputs.All possible weights are considered in the EEP evaluation,then the EEP of a transportation sector is represented by a ranking interval.Finally,the proposed approach is applied to the transportation sectors in 30 Chinese provinces.Results show that the best and the worst ranking of most provinces vary greatly.Besides,the EEP of most provinces is hard to dominate others strictly,but the general tendency is the EEP of eastern provinces better than western provinces.Furthermore,the EEP difference of some adjacent provinces with similar features is distinct.These findings are not all the same as previous studies,which verifies the necessity of considering all possible weights in performance evaluation.Therefore,our method provides a new point of view in performance evaluation and can give more robust results for decision makers. | Xiyang Lei Lin Li Xuefei Zhang Qianzhi Dai Yelin Fu | 2019 | Journal of Systems Science and Systems Engineering2019，28，5： | 3 |
| 4 | Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR显示文摘DNA damage response(DDR)is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs.Hence,small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy.Through a recent chemical library screen,we identified shikonin as an inhibitor that strongly suppressed DDR activated by various chemotherapeutic drugs in cancer cell lines derived from different origins.Mechanistically,shikonin inhibited the activation of ataxia telangiectasia mutated(ATM),and to a lesser degree ATM and RAD3-related(ATR),two master upstream regulators of the DDR signal,through inducing degradation of ATM and ATR-interacting protein(ATRIP),an obligate associating protein of ATR,respectively.As a result of DDR inhibition,shikonin enhanced the anti-cancer effect of chemotherapeutic drugs in both cell cultures and in mouse models.While degradation of ATRIP is proteasome dependent,that of ATM depends on caspase-and lysosome-,but not proteasome.Overexpression of ATM significantly mitigated DDR inhibition and cell death induced by shikonin and chemotherapeutic drugs.These novel findings reveal shikonin as a pan DDR inhibitor and identify ATM as a primary factor in determining the chemo sensitizing effect of shikonin.Our data may facilitate the development of shikonin and its derivatives as potential chemotherapy sensitizers through inducing ATM degradation. | Fangfang Wang Sora Jin Franklin Mayca Pozo Danmei Tian Xiyang Tang Yi Dai Xinsheng Yao Jinshan Tang Youwei Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 0 |
| 5 | Targeted isolation and identification of bioactive pyrrolidine alkaloids from Codonopsis pilosula using characteristic fragmentation-assisted mass spectral networking显示文摘Codonopsis pilosula(CP),a well-known food medicine homology plant,is commonly used in many countries.In our preliminary study,a series of pyrrolidine alkaloids with high MS responses were detected as characteristic absorbed constituents in rat plasma after oral administration of CP extract.However,their structures were unclear due to the presence of various isomers and the lack of reference standards.In the present study,an MS-guided targeted isolation of pyrrolidine alkaloids of CP extract was performed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC/Q-TOF MS).For data analysis under fast data directed acquisition mode(Fast-DDA),an effective approach named characteristic fragmentation-assisted mass spectral networking was successfully applied to discover new pyrrolidine alkaloids with high MS response in CP extract.As a result,seven new pyrrolizidine alkaloids[codonopyrrolidiums C–I(3–9)],together with two known ones(1 and 2),were isolated and identified by NMR spectral analysis.Among them,codonopyrrolidium B(1),codonopyrrolidium D(4)and codonopyrrolidium E(5)were evaluated for lipid-lowering activity,and they could improve high fructose-induced lipid accumulation in HepG2 cells.In addition,the characteristic MS/MS fragmentation patterns of these pyrrolizidine alkaloids were investigated,and 17 pyrrolidine alkaloids were identified.This approach could accelerate novel natural products discovery and characterize a class of natural products with MS/MS fragmentation patterns from similar chemical scaffolds.The research also provides a chemical basis for revealing in vivo effective substances in CP. | TANG Xiyang FAN Cailian ZENG Jiaxing ZHAO Pengcheng WANG Xiaoxing CAI Wanjun LI Ting DAI Yi YAO Zhihong YAO Xinsheng | 2022 | Chinese Journal of Natural Medicines2022，20，12： | 0 |
| 6 | Therapeutic potential of alkaloid extract from Codonopsis Radix in alleviating hepatic lipid accumulation: insights into mitochondrial energy metabolism and endoplasmic reticulum stress regulation in NAFLD mice显示文摘Alkaloids are a class of naturally occurring bioactive compounds that are widely distributed in various food sources and Traditional Chinese Medicine.This study aimed to investigate the therapeutic effects and underlying mechanisms of alkaloid extract from Codonopsis Radix(ACR)in ameliorating hepatic lipid accumulation in a mouse model of non-alcoholic fatty liver disease(NAFLD)induced by a high-fat diet(HFD).The results revealed that ACR treatment effectively mitigated the abnormal weight gain and hepatic injury associated with HFD.Furthermore,ACR ameliorated the dysregulated lipid metabolism in NAFLD mice,as evidenced by reductions in serum triglyceride,total cholesterol,and low-density lipoprotein levels,accompanied by a concomitant increase in the high-density lipoprotein level.ACR treatment also demonstrated a profound anti-oxidative effect,effectively alleviating HFD-induced oxidative stress and promoting ATP production.These effects were achieved through the up-regulation of the activities of mitochondrial electron transfer chain complexes Ⅰ,Ⅱ,Ⅳ,and Ⅴ,in addition to the activation of the AMPK/PGC-1α pathway,suggesting that ACR exhibits therapeutic potential in alleviating the HFD-induced dysregulation of mitochondrial energy metabolism.Moreover,ACR administration mitigated HFD-induced endoplasmic reticulum(ER)stress and suppressed the overexpression of ubiquitin-specific protease 14(USP14)in NAFLD mice.In summary,the present study provides compelling evidence supporting the hepatoprotective role of ACR in alleviating lipid deposition in NAFLD by improving energy metabolism and reducing oxidative stress and ER stress.These findings warrant further investigation and merit the development of ACR as a potential therapeutic agent for NAFLD. | FAN Cailian WANG Guan CHEN Miao LI Yao TANG Xiyang DAI Yi | 2023 | Chinese Journal of Natural Medicines2023，21，6： | 0 |
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